TOYOPEARL GigaCap® S-650M Bulk Media 821835
Toyopearl GigaCap S-650 resin is a high capacity, high resolution cation exchange resin* optimized for process scale applications, including the capture and purification of IgG as well as the polishing of monoclonal antibodies. A Toyopearl HW-65 polymeric bead has been chemically modified to provide a higher number of cationic binding sites for increased resin capacity.
While Toyopearl GigaCap S-650M resin was specifically optimized for IgG, with dynamic binding capacities in the vicinity of 140 mg/mL for IgG, it also exhibits high binding capacities for smaller proteins. Typical dynamic binding capacities for lysozyme are in excess of 160 mg/mL.
Toyopearl GigaCap S-650S resin has dynamic binding capacities approaching 165 g/L for gamma globulin. This high capacity, combined with the 35 µm mean particle size, makes Toyopearl GigaCap S-650S ideal for high resolution applications.
Toyopearl GigaCap S-650 resin is stable at high linear velocities, has good pressure-flow characteristics and will withstand back pressures up to 3 bar. The higher capacity and back pressure stability of Toyopearl GigaCap S-650 resin creates opportunities for increased throughput in downstream cation exchange purification steps.
Toyopearl GigaCap S-650M resin also has excellent base stability in 1.0 mol/L NaOH and shows robust clean in place (CIP) properties with minimal loss of capacity after 50 X 1 hour cycles of caustic exposure also using 1.0 mol/L NaOH. (data)
*specifically designed for packed bed use
Clean in place with 0.5 M NaOH or 0.1 M HCl.
Shipped in 20% (v/v) ethanol.
Discover LiChropur reagents ideal for
HPLC or
LC-MS analysis
Toyopearl is a registered trademark of Tosoh Corporation
Toyopearl GigaCap is a registered trademark of Tosoh Corporation
product line | TOYOPEARL® |
form | 72% (v/v) slurry in 20% (v/v) ethanol |
feature | counter ion Na+ |
packaging | bottle of 1 L |
Торговая марка | Tosoh |
parameter | 3 bar max. pressure |
application(s) | LPLC: suitable |
matrix | hydroxylated methacrylic polymer |
matrix active group | sulphonyl phase |
particle size | 75 µm |
operating pH | 3 - 13 |
capacity | 156 g/L±20 adsorption capacity (hIgG) |
separation technique | cation exchange |