Spectinomycin dihydrochloride pentahydrate

Empirical Formula (Hill Notation):	C14H24N2O7 · 2HCl · 5H2O
CAS Number:	22189-32-8
Molecular Weight:	495.35
EC Number:	244-554-3
MDL number:	MFCD00150886
PubChem Substance ID:	24899581
NACRES:	NA.76

Кат. номер

S4014-25G

S4014-5G-9

S4014-5G

S4014-1G

Chemical structure: aminoglycoside
Spectinomycin has generally been used for the treatment of gonorrhea in males, and a study conducted shows that spectinomycin dihydrochloride pentahydrate provides effective treatment against gonorrhea as well. Clinically, spectinomycin dihydrochloride pentahydrate is easier to use in injections as it shows higher solubility than spectinomycin.
Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.
Spectinomycin dihydrochloride pentahydrate has been used as a supplement in different types of media.
5, 25 g in poly bottle
Mode of Action: Spectinomycin acts by inhibiting protein synthesis and elongation by binding to the bacterial 30S ribosomal subunit and interfering with peptidyl tRNA translocation.
Mode of Resistance: A mutation in rpsE, the gene for ribosomal protein S5, prevents the binding of spectinomycin. Resistance is also conferred by the aminoglycoside-3-adenyltransferase gene (aadA).
Antimicrobial spectrum: Spectinomycin acts against gram-negative and gram-positive bacteria.
Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.
Stock solutions should be prepared at 10 mg/mL in water and filter sterilized.
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Quality Level	200
biological source	synthetic (inorganic)
product line	BioReagent
assay	98.0%
form	powder
potency	603 µg per mg
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
application(s)	cell culture | mammalian: suitable, cell culture | plant: suitable
impurities	endotoxin, tested
color	white to off-white
solubility	H2O: soluble 50 mg/mL at
Featured Industry	Agriculture
Mode of action	protein synthesis | interferes
antibiotic activity spectrum	Gram-negative bacteria, Gram-positive bacteria
storage temp.	2-8°C
SMILES string	O.O.O.O.O.Cl.Cl.CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O
InChI	1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1
InChI key	DCHJOVNPPSBWHK-UXXUFHFZSA-N

Personal Protective Equipment	Eyeshields, Gloves, type N95 (US)
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable