Ivermectin
CAS Number: | 70288-86-7 |
MDL number: | MFCD00869511 |
PubChem Substance ID: | 24278497 |
NACRES: | NA.77 |
Кат. номер |
I8898-250MG |
I8898-1G |
Ivermectin is a macro-cyclic lactone, derived from avermectin. It functions as an antiparasitic agent. Ivermectin is used against gastrointestinal roundworms, lungworms, mites and lice. It is used to treat onchocerciasis, strongyloidiasis, ascariasis and filariases.
Ivermectin has been used:
- in Caenorhabditis elegans fecundity assay
- in larval development test
- to measure in vivo topical acaricide activity of compounds in rats
- to assess its acute and chronic effects to zebrafish
- in percutaneous drug injection method to treat cystic echinococcosis
- in liquid chromatography with fluorescence detection method
250 mg in poly bottle
1 g in poly bottle
Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.
This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
Primarily ivermectin B1a.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Quality Level | 100 |
form | powder |
solubility | MEK: 50 mg/mL |
Featured Industry | Agriculture Environmental |
Mode of action | cell membrane | interferes |
antibiotic activity spectrum | parasites |
originator | Merck & Co., Inc., Kenilworth, NJ, U.S. |
storage temp. | 2-8°C |
SMILES string | [H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(C)\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\C=C\C=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC |
InChI | 1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1 |
InChI key | AZSNMRSAGSSBNP-XPNPUAGNSA-N |
Gene Information | human ... ABCB1(5243), CYP3A4(1576) mouse ... Abcb1a(18671), Abcb1b(18669) |
Pictograms | GHS06,GHS08,GHS09 |
Signal Word | Danger |
Hazard Statements | H300 - H311 - H351 - H360D - H410 |
Precautionary Statements | P202 - P264 - P273 - P280 - P301 + P310 - P302 + P352 + P312 |
Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
RIDADR | UN 2811 6.1 / PGII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |