Calcium folinate for system suitability Y0002071
Empirical Formula (Hill Notation): | C20H21CaN7O7 · xH2O |
CAS Number: | 1492-18-8 |
Molecular Weight: | 511.50 (anhydrous basis) |
Beilstein/REAXYS Number: | 5723924 |
Calcium folinate, the reduced form of folic acid, finds application in the treatment of methotrexate overdose and in high-dose methotrexate chemotherapy as a chemotherapy protective drug to bring down the latter′s toxicity. When combined with fluorouracil, it is reported to be effective in the management of bowel cancer wherein it acts by inhibiting thymidylate synthase and augmenting the effect of fluorouracil.
This product is provided as delivered and specified by the issuing Pharmacopoeia. Calcium folinate for system suitability may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.
Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.
Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. Sales restrictions may apply.
biological source | synthetic |
grade | pharmaceutical primary standard |
Agency/Method | EP |
form | solid |
Торговая марка | EDQM |
application(s) | gas chromatography (GC): suitable, liquid chromatography (LC): suitable |
format | neat |
storage temp. | −20°C |
SMILES string | [Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13 |
pictograms | GHS07,GHS08 |
signalword | Danger |
hcodes | H315 - H317 - H319 - H334 - H335 |
pcodes | P261 - P264 - P280 - P280 - P304 + P340 + P312 - P342 + P311 |
Target Organs | Respiratory system |
WGK Germany | WGK 3 |
Flash Point F | Not applicable |
Flash Point C | Not applicable |