Propyl gallate for ID and assay Y0002116

Empirical Formula (Hill Notation):	C10H12O5
Linear Formula:	3,4,5-(HO)3C6H2CO2CH2CH2CH3
CAS Number:	121-79-9
Molecular Weight:	212.20
Beilstein/REAXYS Number:	1877976
MDL number:	MFCD00002196

This product is provided as delivered and specified by the issuing Pharmacopoeia. Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.
An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis.
An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 µM when it was combined with copper concentrations at 5 µM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis.
Unit quantity: 80 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. Prepare a 0.1M solution in glycerol:PBS (9:1)
Sales restrictions may apply.

Торговая марка	EDQM
mp	146-149 °C (lit.)
storage temp.	2-8°C
SMILES string	CCCOC(=O)c1cc(O)c(O)c(O)c1
InChI	1S/C10H12O5/c1-2-3-15-10(14)6-4-7(11)9(13)8(12)5-6/h4-5,11-13H,2-3H2,1H3
InChI key	ZTHYODDOHIVTJV-UHFFFAOYSA-N

pictograms	GHS05,GHS07,GHS09
signalword	Danger
hcodes	H302 - H317 - H318 - H410
pcodes	P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
WGK Germany	WGK 2
Flash Point F	368.6 °F - closed cup
Flash Point C	187 °C - closed cup