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NI-57
Empirical Formula (Hill Notation): C19H17N3O4S Molecular Weight: 383.42 PubChem Substance ID: 329825915 NACRES: NA.77
Кат. номер SML1486-5MG SML1486-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
NI-57 is a selective and potent inhibitor of BRPF (Bromodomain and PHD Finger) family of proteins (BRPF1/2/3). NI-57 shows accelerated FRAP recovery at 1 µM in the BRPF2 FRAP assay preventing binding of full-length BRPF2 to chromatin. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc,
Features and Benefits
NI-57 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC,.
This compound is a featured product for Gene Regulation research. Click here, to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.ПараметрыQuality Level 100, assay ≥98% (HPLC) form powder color white to beige solubility DMSO: 20 mg/mL, clear storage temp. 2-8°C SMILES string O=S(NC1=CC=C(N(C)C(C(C)=C2)=O)C2=C1)(C3=C(OC)C=C(C#N)C=C3)=O InChI 1S/C19H17N3O4S/c1-12-8-14-10-15(5-6-16(14)22(2)19(12)23)21-27(24,25)18-7-4-13(11-20)9-17(18)26-3/h4-10,21H,1-3H3 InChI key UEMQPCYDWCSVCU-UHFFFAOYSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P301 + P310 + P330 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
NVS-CECR2-1
Empirical Formula (Hill Notation): C27H37N5O2S CAS Number: 1992047-61-6 Molecular Weight: 495.68 MDL number: MFCD30290159 PubChem Substance ID: 329826076
Кат. номер SML1803-5MG SML1803-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
NVS-CECR2-1 (NVS-1) is a potent and selective inhibitor of CECR2 (cat eye syndrome chromosome region, candidate 2) gene. CECR2 is duplicated in the human disorder cat eye syndrome, which includes defects of the eye, heart, anus, kidney, skeleton, face, and may include mild mental deficiency. CECR2 is involved in neurulation, the folding process that results in the transformation of the neural plate into the neural tube, and is also thought to play a role in DNA damage response. NVS-CECR2-1 (NVS-1) binds to CECR2 with high affinity. It has an IC50 value of 47 nM in Alpha screen and a KD of 80 nM in ITC. NVS-CECR2-1 showed no cross reactivity in a BRD panel of 48 targets or any major activity in kinase, protease and receptor panels. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc,
Features and Benefits
NVS-CECR2-1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC,.
This compound is a featured product for Gene Regulation research. Click here, to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.ПараметрыQuality Level 100, assay ≥98% (HPLC) form powder color white to beige solubility DMSO: 10 mg/mL, clear storage temp. −20°C SMILES string CC(NC(C)(C)C1)(C)CC1N2C=CC3=C2C=CC(C4=NC(S(CCC)(=O)=O)=NC(NC5CC5)=C4)=C3
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
NVS-PAK1-1
Empirical Formula (Hill Notation): C23H25ClF3N5O CAS Number: 1783816-74-9 Molecular Weight: 479.93
Кат. номер SML1867-5MG SML1867-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. NVS-PAK1-1 showed good selectivity against 442 other kinases including PAK2. NVS-PAK1-1 has generally good physicochemical properties, but was metabolized by rat liver microsomes, so may not be useful for in vivo work. To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc,
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here, to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,
NVS-PAK1-1 is a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC,ПараметрыQuality Level 100, assay ≥98% (HPLC) form powder color white to beige solubility DMSO: 30 mg/mL, clear storage temp. 2-8°C SMILES string FC(F)CN1C2=C(C=C(Cl)C=C2)C(N[C@H]3CCN(C(NC(C)C)=O)C3)=NC4=C1C=CC(F)=C4
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
OF-1
Empirical Formula (Hill Notation): C17H18BrN3O4S CAS Number: 919973-83-4 Molecular Weight: 440.31 MDL number: MFCD26964046 PubChem Substance ID: 329825706 NACRES: NA.77
Кат. номер SML1184-5MG SML1184-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
OF-1 is a chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) family of scaffolding proteins (BRPF1, BRPF2, BRPF3) that assemble histone acetyltransferase (HAT) complexes of the MYST family members MOZ and MORF. The BRPF1 protein is the scaffold subunit of the MYST acetyltransferase complex, which plays a crucial roles in DNA repair, recombination and replication as well as transcription activation. OF-1 binds to BRPF1B with a Kd of 100 nM , to BRPF2 with a Kd of 500 nM and to BRPF3 with a Kd of 2.4 mM, and shows >100-fold selectivity against most other bromodomains. The closest off-target effects are against BRD4 (39-fold selectivity) and 50% inhibition of TIF1a at 20 µM. For full characterization details, please see OF-1, on the Structural Genomics Consortium (SGC) website.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc,
Features and Benefits
OF-1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC,.
This compound is a featured product for Gene Regulation research. Click here, to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.ПараметрыQuality Level 100, assay ≥98% (HPLC) form powder color white to beige solubility DMSO: 5 mg/mL, clear (warmed) storage temp. 2-8°C SMILES string BrC1=CC(C)=C(S(NC(C(OC)=C2)=CC(N3C)=C2N(C)C3=O)(=O)=O)C=C1 InChI 1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3 InChI key YUNQZQREIHWDQT-UHFFFAOYSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 - H319 pcodes P301 + P310 + P330 - P305 + P351 + P338 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
OICR-9429
Empirical Formula (Hill Notation): C29H32F3N5O3 CAS Number: 1801787-56-3 Molecular Weight: 555.59 MDL number: MFCD18364451 PubChem Substance ID: 329825720 NACRES: NA.77
Кат. номер SML1209-5MG SML1209-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
OICR-9429 is a cell penetrant, potent and selective antagonist of the interaction of WDR5 (WD repeat domain 5) with peptide regions of MLL and Histone 3 that potently binds to WDR5. OICR-9429 inhibits the interaction of WDR5 with MLL1 and RbBP5 in cells. For full characterization details, please see OICR-9429, on the Structural Genomics Consortium (SGC) website.
OICR-0547 is the negative control for the active probe, OICR-9429. To request a sample of the negative control from the SGC, click here,.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc,
Features and Benefits
OICR-9429 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC,.
This compound is a featured product for Gene Regulation research. Click here, to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.Other NotesOICR-9429 has been expertly reviewed and recommended by the Chemical Probes Portal.ПараметрыQuality Level 100, assay ≥98% (HPLC) form powder color white to light brown solubility DMSO: 10 mg/mL, clear storage temp. 2-8°C InChI 1S/C7H5FN2O2/c1-2-3-10-4-5(8)6(11)9-7(10)12/h1,4H,3H2,(H,9,11,12) InChI key GMCOGJQJFDQZCP-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PFI-1
Empirical Formula (Hill Notation): C16H17N3O4S CAS Number: 1403764-72-6 Molecular Weight: 347.39 MDL number: MFCD22580416 PubChem Substance ID: 329825355 NACRES: NA.77
Кат. номер SML0352-5MG SML0352-25MG ApplicationPFI-1 has been used as a bromodomain inhibitor in breast cancer cell line MCF7 dechorionated zebrafish embryos. It has also been used in human peripheral blood mononuclear cells (PBMCs), to inhibit the release of interleukin-6 in lipopolysaccharide (LPS) challenge assay.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PFI-1 is a quinazolinone inhibits androgen receptor (AR) mediated signaling in prostate cancer cells. It elicits minimum toxicity and is effective for anti-HIV-latency therapy. In leukemia cells, PFI-1 inhibits Aurora B kinase and promotes caspase-dependent apoptosis.
The human BET family, which includes BRD2, BRD3, BRD4 and BRDT, play a role in regulation of gene transcription. PFI-1 is a selective BET bromodomain inhibitor with activity at BRD2 (IC50 = 98 nM) and BRD4 (IC50 = 220 nM). To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc,
Features and Benefits
PFI-1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC,.
This compound is a featured product for Gene Regulation research. Click here, to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.Other NotesPFI-1 has been expertly reviewed and recommended by the Chemical Probes Portal.ПараметрыQuality Level 100, assay ≥98% (HPLC) form powder color white to beige solubility DMSO: ≥10 mg/mL storage temp. 2-8°C SMILES string COc1ccccc1S(=O)(=O)Nc2ccc3NC(=O)N(C)Cc3c2 InChI 1S/C16H17N3O4S/c1-19-10-11-9-12(7-8-13(11)17-16(19)20)18-24(21,22)15-6-4-3-5-14(15)23-2/h3-9,18H,10H2,1-2H3,(H,17,20) InChI key TXZPMHLMPKIUGK-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PFI-3
Empirical Formula (Hill Notation): C19H19N3O2 Molecular Weight: 321.37 PubChem Substance ID: 329825619 NACRES: NA.77
Кат. номер SML0939-IP SML0939-5MG SML0939-25MG Packaging5, 25 mg in glass bottleBiochem/physiol ActionsSMARCA4 (SWI/SNF related, Matrix associated, Actin dependent Regulator of Chromatin, subfamily A, member 4) is a transcriptional activator and is a component of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. SMARC4 (also known as BRG1) and the related protein SMARCA2 (also known as BRM) contain a bromodomain that is structurally similar to the PolyBromo1 (PB1) 5 bromodomain. PFI-3 is a selective chemical probe for SMARCA bromodomains that inhibits SMARCA2, SMARCA4 and PB1(5) bromodomains. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgcFeatures and BenefitsPFI-3 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.ПараметрыQuality Level 100 assay ≥98% (HPLC) form powder color yellow to orange solubility DMSO: 10 mg/mL, clear storage temp. 2-8°C SMILES string OC1=C(C(/C=C/N2[C@H](C3)CN(C4=NC=CC=C4)[C@H]3C2)=O)C=CC=C1 InChI 1S/C19H19N3O2/c23-17-6-2-1-5-16(17)18(24)8-10-21-12-15-11-14(21)13-22(15)19-7-3-4-9-20-19/h1-10,14-15,23H,11-13H2/b10-8+/t14-,15-/m1/s1 InChI key INAICWLVUAKEPB-QSTFCLMHSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SGC-AAK1-1
Empirical Formula (Hill Notation): C21H25N5O3S Molecular Weight: 427.52
Кат. номер SML2219-5MG SML2219-25MG
Biochem/physiol Actions
SGC-AAK1-1 is an ATP-competitive kinase inhibitor against AP2-associated protein kinase 1/AAK1 and BMP-2-inducible protein kinase/BIKE/BMP2K (Ki = 9.1 & 17 nM, respectively, by ATP site fluorescent tracer displacement assay; AAK1 IC50 = 270 nM by coupled enzyme assay). SGC-AAK1-1 downregulates cellular AP2M1 Thr156 phosphorylation level in a dose-dependent manner (ECmax 12.5 µM) without detectable cytotoxicity. Selectivity profiling identifies only 5 additional kinases among a panel of 400 with >50% inhibition by 1 µM SGC-AAK1-1 (KD = 72 nM/RIOK1, 290 nM/RIOK3, 260 nM/PIP5K1C, 880 nM/CDKL1, 960 nM/MYLK2 by DiscoverX KINOMEscan). SGC-AAK1-1N is a structure analog and the recommended negative control (IC50 = 11 µM by AAK1 activity assay; KD = 8.8 µM/AAK1 & >10 µM/BIKE vs. KD = 26 nM/AAK1 & 930 nM/BIKE with SGC-AAK1-1 by DiscoverX). SGC-AAK1-1N is the negative control for the active probe, SGC-AAK1-1. SGC-AAK1-1N is available from Sigma. To learn more about and purchase SGC-AAK1-1N, click here,.
To learn about other SGC chemical probes, visit sigma.com/sgc,
Features and Benefits
SGC-AAK1-1 is a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC,.Параметрыassay ≥98% (HPLC) form powder color white to beige solubility DMSO: 2 mg/mL, clear storage temp. 2-8°C SMILES string CCN(CC)S(NC1=CC=CC(C2=CC(NN=C3NC(C4CC4)=O)=C3C=C2)=C1)(=O)=O
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SGC-AAK1-1N
Empirical Formula (Hill Notation): C20H22N4O3S Molecular Weight: 398.48 NACRES: NA.77
Biochem/physiol ActionsКат. номер SML2220-5MG SML2220-25MG
SGC-AAK1-1N is a structure analog of and the recommended negative control for SGC-AAK1-1, (AAK1 IC50 = 11 µM and 270 nM, respectively, by coupled enzyme assay; KD = 8.8 µM/AAK1 & >10 µM/BIKE with SGC-AAK1-1N vs. KD = 26 nM/AAK1 & 930 nM/BIKE with SGC-AAK1-1). SGC-AAK1-1, the active probe, is available from Sigma. To learn more about and purchase SGC-AAK1-1, click here,.
To learn about other SGC chemical probes, visit sigma.com/sgc,
Features and Benefits
SGC-AAK1-1N is a negative control for SGC-AAK1-1, a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC,Параметрыassay ≥98% (HPLC) form powder color white to beige solubility DMSO: 2 mg/mL, clear storage temp. 2-8°C SMILES string O=C(C(C)C)NC1=NNC2=C1C=CC(C3=CC(NS(C4CC4)(=O)=O)=CC=C3)=C2
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SGC-CBP30
Empirical Formula (Hill Notation): C28H33ClN4O3 Molecular Weight: 509.04 PubChem Substance ID: 329825669 NACRES: NA.77
Кат. номер SML1133-5MG SML1133-25MG ApplicationSGC-CBP30 has been used in immunofluorescence, to study the regulation of HAT (histone acetyltransferase) activity. It has also been used to abolish synergistic gene expression induced by transcription factors in hepatocytes.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
SGC-CBP30 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.021 and 0.038 µM, respectively). SGC-CBP30 has little activity against other bromodomains at concentrations up to 1 mM. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc,
SGC-CBP30 might serve as a therapeutic agent in treating cancer. In ankylosing spondylitis and psoriatic arthritis condition, SGC-CBP30 is found to decrease immune cell production of T helper cell 17 and other pro-inflammatory cytokines.
Features and Benefits
SGC-CBP30 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC,.
This compound is a featured product for Gene Regulation research. Click here, to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.Other NotesSGC-CBP30 has been expertly reviewed and recommended by the Chemical Probes Portal.ПараметрыQuality Level 100, assay ≥98% (HPLC) form powder color white to beige solubility DMSO: 10 mg/mL, clear storage temp. 2-8°C SMILES string CC1=C(C(C)=NO1)C2=CC=C3C(N=C(CCC4=CC=C(OC)C(Cl)=C4)N3C[C@@H](N5CCOCC5)C)=C2 InChI 1S/C28H33ClN4O3/c1-18(32-11-13-35-14-12-32)17-33-25-8-7-22(28-19(2)31-36-20(28)3)16-24(25)30-27(33)10-6-21-5-9-26(34-4)23(29)15-21/h5,7-9,15-16,18H,6,10-14,17H2,1-4H3/t18-/m0/s1 InChI key GEPYBHCJBORHCE-SFHVURJKSA-N
Safety Informationhcodes H413 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SGC-GAK-1
Empirical Formula (Hill Notation): C18H17BrN2O3 Molecular Weight: 389.24 NACRES: NA.77
Кат. номер SML2202-5MG SML2202-25MG
Biochem/physiol Actions
SGC-GAK-1 (CA93) is an ATP-competitive cyclin G-associated kinase (GAK) inhibitor (Ki = 3.1 nM by ATP site fluorescent tracer displacement assay; KD = 4.5 nM by ITC) that effectively inhibits Dengue viral entry and packaging in cultures (IC50 = 920 nM) without detectable cytotoxicity. SGC-GAK-1 exhibits much reduced affinity toward only 4 other kinases among a panel of 400 (KD = 1.9 nM/GAK vs. 110 nM/RIPK2, 190 nM/ADCK3, 520 nM/NLK, 980 nM/AVCR1 by ligand competitive binding assay; IC50 = 110 nM/GAK vs. 360 nM/RIPK2 by cellular target engagement assay). SGC-GAK-1N (CA71) is a structure analog and the recommended negative control (GAK KD = 7.1 µM by ligand competitive binding assay; GAK & RIPK2 IC50 >50 µM by cellular target engagement assay). SGC-GAK-1N is the negative control for the active probe, SGC-GAK-1. SGC-GAK-1N is available from Sigma. To learn more about and purchase SGC-GAK-1N, click here,.
To learn about other SGC chemical probes, visit sigma.com/sgc,
Features and Benefits
SGC-GAK-1 is a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC,.Параметрыassay ≥98% (HPLC) form powder color white to beige solubility DMSO: 2 mg/mL, clear storage temp. 2-8°C SMILES string BrC1=CC2=C(NC3=CC(OC)=C(OC)C(OC)=C3)C=CN=C2C=C1
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SGC-GAK-1N
Empirical Formula (Hill Notation): C20H19F3N2O3 Molecular Weight: 392.37 NACRES: NA.77
Biochem/physiol ActionsКат. номер SML2203-5MG SML2203-25MG
SGC-GAK-1N (CA71) is a structure analog of and the recommended negative control for the ATP-competitive cyclin G-associated kinase (GAK) inhibitor SGC-GAK-1 (CA93), (GAK KD = 1.9 nM/SGC-GAK-1 vs. 7.1 µM/SGC-GAK-1N by ligand competitive binding assay; GAK IC50 = 110 nM/SGC-GAK-1 vs. >50 µM/SGC-GAK-1N by cellular target engagement assay; Dengue viral entry and packaging IC50 = 920 nM/SGC-GAK-1 vs. >10 µM/SGC-GAK-1N). SGC-GAK-1, the active probe, is available from Sigma. To learn more about and purchase SGC-GAK-1, click here,.
To learn about other SGC chemical probes, visit sigma.com/sgc,
Features and Benefits
SGC-GAK-1N is a negative control for SGC-GAK-1, a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC,Параметрыassay ≥98% (HPLC) form powder color dark green to black solubility DMSO: 2 mg/mL, clear storage temp. 2-8°C SMILES string CN(C1=CC(OC)=C(OC)C(OC)=C1)C2=C3C(C=CC(C(F)(F)F)=C3)=NC=C2
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SGC0946
Empirical Formula (Hill Notation): C28H40BrN7O4 CAS Number: 1561178-17-3 Molecular Weight: 618.57 MDL number: MFCD26523136 PubChem Substance ID: 329825482 NACRES: NA.77
Кат. номер SML1107-5MG SML1107-25MG Packaging5, 25 mg in glass bottleBiochem/physiol ActionsSGC0946 is a potent and selective inhibitor of Histone H3-lysine79 (H3K79) methyltransferase DOT1L with an IC50 of 0.3 nM in a radioactive enzyme assay, and over 100-fold selectivity for DOT1L over other histone methyltransferases. In cell studies, SGC0946 reduces H3K79 dimethylation with an IC50 of 2.6 nM in A431 cells and 8.8 nM in MCF10A cells. SGC0946 was found to selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia. SGC0649 is the negative control for the active probe, SGC0946. To request a sample of the negative control from the SGC, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgcFeatures and BenefitsThis compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
SGC0946 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.Other NotesSGC0946 has been expertly reviewed and recommended by the Chemical Probes Portal.ПараметрыQuality Level 100 assay ≥98% (HPLC) form powder color white to beige solubility DMSO: 20 mg/mL, clear storage temp. −20°C SMILES string BrC1=CN([C@@H]2O[C@H](CN(CCCNC(NC3=CC=C(C(C)(C)C)C=C3)=O)C(C)C)[C@@H](O)[C@H]2O)C4=C1C(N)=NC=N4 InChI 1S/C28H40BrN7O4/c1-16(2)35(12-6-11-31-27(39)34-18-9-7-17(8-10-18)28(3,4)5)14-20-22(37)23(38)26(40-20)36-13-19(29)21-24(30)32-15-33-25(21)36/h7-10,13,15-16,20,22-23,26,37-38H,6,11-12,14H2,1-5H3,(H2,30,32,33)(H2,31,34,39)/t20-,22-,23-,26-/m1/s1 InChI key IQCKJUKAQJINMK-HUBRGWSESA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P301 + P310 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SGC3027
Empirical Formula (Hill Notation): C41H47ClN6O6S Molecular Weight: 787.37
Кат. номер SML2343-5MG SML2343-25MG Biochem/physiol ActionsSGC3027 is a selective and cell-active inhibitor of protein arginine N-methyltransferase (PRMT7) It is a pro-drug of the active component, SGC8158, which is produced in the cell by reductases. SGC8158 was shown to inhibit PRMT7 with an IC50 value < 2.5 nM for methylation of H2B (23-37) and greater than 40-fold selectivity over other histone methyltransferases and non-epigenetic targets. SGC3027 inhibited the methylation of HSP70 In cellular assays using C2C12 cells with an IC50 value of 1.3 microM. The closely related SGC3027N is significantly less active in the cellular assay, and is a control compound for cellular studies.Параметрыassay ≥98 mg/mL (HPLC) form powder color white to beige solubility DMSO: 2 mg/mL, clear storage temp. −20°C SMILES string ClC(C=C1)=CC=C1C2=CC(CN(C(CC(C)(C)C(C(C(C)=C3C)=O)=C(C)C3=O)=O)CCCCSC[C@H]4O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)[C@H](O)[C@@H]4O)=CC=C2
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SGC3027N
Empirical Formula (Hill Notation): C44H51ClN6O6S Molecular Weight: 827.43
Biochem/physiol ActionsКат. номер SML2342-5MG SML2342-25MG
SGC3027N is the control probe for the PRMT7 inhibitor SGC3027
Control probe for PRMT7 inhibitor SGC3027Параметрыassay ≥98% (HPLC) form powder color white to beige solubility DMSO: 2 mg/mL, clear storage temp. 2-8°C SMILES string ClC(C=C1)=CC=C1C2=CC(CN(C(CC(C)(C)C(C(C(C)=C3C)=O)=C(C)C3=O)=O)CCCCSC[C@H]4O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)[C@H]7[C@@H]4OC(C)(C)O7)=CC=C2
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SGC707
Empirical Formula (Hill Notation): C16H18N4O2 Molecular Weight: 298.34 PubChem Substance ID: 329825739 NACRES: NA.77
Кат. номер SML1242-5MG SML1242-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
SGC707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). SGC707 has an IC50 value of 50 nM and >100-fold selectivity over other methyltransferases and non-epigenetic targets. SGC707 binds to PRMT3 with KD of 50 nM (ITC), and inhibits histone methylation in cells with an IC50 value below 1 µM. XY1 is the negative control for the active probe, SGC707. To request a sample of the negative control from the SGC, click here,.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc,
Features and Benefits
SGC707 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC,.
This compound is a featured product for Gene Regulation research. Click here, to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.Other NotesSGC707 has been expertly reviewed and recommended by the Chemical Probes Portal.ПараметрыQuality Level 100, assay ≥98% (HPLC) form powder color white to light brown solubility DMSO: 20 mg/mL, clear storage temp. 2-8°C SMILES string O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2 InChI 1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22) InChI key DMIDPTCQPIJYFE-UHFFFAOYSA-N
Safety Informationpictograms GHS05 signalword Danger hcodes H318 pcodes P280 - P305 + P351 + P338 + P310 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
SGC8158
Empirical Formula (Hill Notation): C27H31ClN6O3S Molecular Weight: 555.09
Biochem/physiol ActionsКат. номер SML2340-5MG SML2340-25MG
SGC8158 isthe active component produced by cell reductases from the prodrug, SGC3027, a selective and cell-active inhibitor of protein arginine N-methyltransferase (PRMT7). SGC8158 was shown to inhibit PRMT7 with an IC50 value < 2.5 nM for methylation of H2B (23-37) and greater than 40-fold selectivity over other histone methyltransferases and non-epigenetic targets. SGC3027 inhibited the methylation of HSP70 In cellular assays using C2C12 cells with an IC50 value of 1.3 microM. The closely related SGC3027N is significantly less active in the cellular assay, and is a control compound for cellular studies.ПараметрыQuality Level 100, assay ≥98% (HPLC) form powder color white to beige solubility DMSO: 2 mg/mL, clear storage temp. 2-8°C SMILES string ClC(C=C1)=CC=C1C2=CC(CNCCCCSC[C@H]3O[C@@H](N(C=N4)C5=C4C(N)=NC=N5)[C@H](O)[C@@H]3O)=CC=C2
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
T-26c
Empirical Formula (Hill Notation): C24H21N3O6S CAS Number: 869296-13-9 Molecular Weight: 479.51
PackagingКат. номер SML1915-5MG SML1915-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
T-26c is a highly potent, selective and cell-permeable matrix metalloproteinases 13 (MMP-13) inhibitor. T-26c inhibits the breakdown of collagen (87.4% inhibition at 0.1 µM) in IL-1b and oncostatin M stimulated cartilage. To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc,
Features and Benefits
T-26c is a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC,.ПараметрыQuality Level 100, assay ≥98% (HPLC) form powder color white to beige solubility DMSO: 10 mg/mL, clear storage temp. 2-8°C SMILES string OC(C(C=C1)=CC=C1COCC2=CSC3=C2C(NC(C(NCC4=CC=CC(OC)=C4)=O)=N3)=O)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Узнать цену -
TH-257
Empirical Formula (Hill Notation): C24H26N2O3S Molecular Weight: 422.54
Biochem/physiol ActionsКат. номер SML2275-5MG SML2275-25MG
TH-257 is a potent, type III allosteric LIM-kinase (LIMK1 & LIMK2) inhibitor (LIMK1/2 IC50 in nM = 48/29 by cell-free kinase assay and 250/150 by live cell NanoBRET assay using respective transfectants) that targets LIMK1/2 DFG-out conformation in a non-ATP-competitive manner and exhibits no significant off-target activity by KINOMEscan assay at 1 µM. TH-263 is a structure analog and the recommended negative control for TH-257. TH-263 is the negative control for the active probe, TH-257. TH-263 is available from Sigma. To learn more about and purchase TH-263, click here,.
To learn about other SGC chemical probes, visit sigma.com/sgc,
Features and Benefits
TH-257 is a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC,.Параметрыassay ≥98% (HPLC) form powder color white to beige solubility DMSO: 2 mg/mL, clear storage temp. 2-8°C SMILES string O=C(C1=CC=C(C=C1)S(NC2=CC=CC=C2)(=O)=O)N(CC3=CC=CC=C3)CCCC
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
TP-472
Empirical Formula (Hill Notation): C20H19N3O2 Molecular Weight: 333.38 NACRES: NA.77
Кат. номер SML1862-5MG SML1862-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
TP-472 is a selective probe for bromodomain-containing proteins BRD9 and BRD7. This BRD9/7 probe was developed out of a collaborative effort by Takeda and the SGC, and is of a different chemotype from BRD9/7 probes previously available. TP-472 has a KD value of 33nM for BRD9 and 340nM for BRD7 by ITC. It is >30 fold selective for BRD9 over all other bromodomain family members except BRD7. It is suitable for in vivo applications. TP-472N is used as a negative control and is available from Sigma. To learn more about and purchase TP-472N, click here,.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc,
Features and Benefits
TP-472 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC,
This compound is a featured product for Gene Regulation research. Click here, to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.ПараметрыQuality Level 100, assay ≥98% (HPLC) form powder color white to beige solubility DMSO: 10 mg/mL, clear storage temp. 2-8°C SMILES string O=C(C)C1=CC(C2=C(C)C=CC(C(NC3CC3)=O)=C2)=C4N=CC=CN41
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Узнать цену -
TP-472N
Empirical Formula (Hill Notation): C19H18N2O2 CAS Number: 2080306-24-5 Molecular Weight: 306.36 MDL number: MFCD30720894
Кат. номер SML1933-5MG SML1933-25MG
Biochem/physiol Actions
TP-472N is a negative control probe for TP-472,. TP-472 is a selective probe for bromodomain-containing proteins BRD9 and BRD7. The BRD9/7 probe was developed out of a collaborative effort by Takeda and the SGC, and is of a different chemotype from BRD9/7 probes previously available. TP-472 has a KD value of 33nM for BRD9 and 340nM for BRD7 by ITC, is >30 fold selective for BRD9 over all other bromodomain family members except BRD7, and is suitable for in vivo applications. The negative control TP-472N is inactive against other bromodomains (>20µM against BRD9). TP-472, the active BRD9/7 probe, is available from Sigma. To learn more about and purchase TP-472, click here,.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc,
Features and Benefits
TP-472N is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC,.
This compound is a featured product for Gene Regulation research. Click here, to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.ПараметрыQuality Level 100, assay ≥98% (HPLC) form powder color white to beige solubility DMSO: 15 mg/mL, clear storage temp. 2-8°C SMILES string O=C(C)C1=CC(C2=CC=CC=C2OCC3CC3)=C4N=CC=CN41
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
UNC0638 hydrate
Empirical Formula (Hill Notation): C30H47N5O2 · xH2O Molecular Weight: 509.73 (anhydrous basis) MDL number: MFCD17215972 PubChem Substance ID: 329827633 NACRES: NA.77
Кат. номер U4885-IP U4885-5MG U4885-25MG General descriptionUNC0638 enhances the E-cadherin expression in gemcitabine-resistant cell line (PANC-1-R).ApplicationUNC0638 hydrate has been used:- in fractionation and isolation of human blood cells and cell nuclei
- in the analysis of human immunodeficiency virus (HIV) reactivation in latently infected cell line
- to determine the effect of G9a and its enzymatic activity on cisplatin resistance
UNC0638 has been used to block G9a (a lysine methyltransferase) function in C2C12 cells. UNC0638 has also been reported to decrease H3K9 dimethylation (H3K9me2) levels and inhibit cell death in hair cells.Packaging5, 25 mg in glass bottleBiochem/physiol ActionsUNC0638 hydrate is a histone methyltransferase (HMT) inhibitor. UNC0638 shows selectivity for G9a (EHMT2) and GLP (EHMT1) methyltransferases, which catalyze the methylation of lysine 9 of histone 3 (H3K9) as well as other non-histone substrates. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgcFeatures and BenefitsThis compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
UNC0638 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.Other NotesUNC0638 has been expertly reviewed and recommended by the Chemical Probes Portal.ПараметрыQuality Level 100 assay ≥98% (HPLC) form solid storage condition protect from light color off-white solubility DMSO: >10 mg/mL storage temp. −20°C SMILES string O.COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN4CCCC4)C5CCCCC5 InChI 1S/C30H47N5O2.H2O/c1-22(2)35-17-12-24(13-18-35)31-30-25-20-27(36-3)28(37-19-9-16-34-14-7-8-15-34)21-26(25)32-29(33-30)23-10-5-4-6-11-23;/h20-24H,4-19H2,1-3H3,(H,31,32,33);1H2 InChI key LLJGACAJGYXBTL-UHFFFAOYSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H300 - H413 pcodes P273 - P301 + P310 + P330 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
UNC0642
Empirical Formula (Hill Notation): C29H44F2N6O2 Molecular Weight: 546.70 MDL number: MFCD28044322 PubChem Substance ID: 329825635 NACRES: NA.77
Кат. номер SML1037-IP SML1037-5MG SML1037-25MG ApplicationUNC0642 has been used to treat human HeLa cells to inhibit the DNA ligase 1 (LIG1) /UHRF1 (ubiquitin-like with PHD and ring finger domains 1) interaction.Packaging5, 25 mg in glass bottleBiochem/physiol ActionsUNC0642 is a potent, selective inhibitor of histone methyltransferases G9a (EHMT2) and GLP (EHMT1), which catalyze the mono and dimethylation of lysine 9 of histone 3 (H3K9), and other non-histone substrates such as p53 and WIZ. UNC0642 has an in vitro IC50 <15 nM with greater than 100-fold selectivity over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. UNC0642 has the same potency with improved PK properties relative to UNC0638, which should make it a more useful probe in an in vivo setting. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgcFeatures and BenefitsThis compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
UNC0642 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.Other NotesUNC0642 has been expertly reviewed and recommended by the Chemical Probes Portal.ПараметрыQuality Level 100 assay ≥98% (HPLC) form powder color white to beige solubility DMSO: 5 mg/mL, clear (warmed) storage temp. 2-8°C SMILES string FC(CC1)(F)CCN1C2=NC(NC3CCN(C(C)C)CC3)=C4C(C=C(OCCCN5CCCC5)C(OC)=C4)=N2 InChI 1S/C29H44F2N6O2/c1-21(2)36-14-7-22(8-15-36)32-27-23-19-25(38-3)26(39-18-6-13-35-11-4-5-12-35)20-24(23)33-28(34-27)37-16-9-29(30,31)10-17-37/h19-22H,4-18H2,1-3H3,(H,32,33,34) InChI key RNAMYOYQYRYFQY-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
UNC1215
Empirical Formula (Hill Notation): C32H43N5O2 CAS Number: 1415800-43-9 Molecular Weight: 529.72 MDL number: MFCD22683289 PubChem Substance ID: 329825577 NACRES: NA.77
Кат. номер SML0662-5MG SML0662-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
UNC1215 is a potent, selective antagonist of L3MBTL3 with cellular activity. Lethal (3) malignant brain tumor-like protein 3 (L3MBTL3) is a putative polycomb group (PcG) protein with gene-repressing activity, a member of the MBT family of methyllysine binders. Methyl-lysine binding proteins are a family of proteins that are important epigenetic regulators that “read” the post-translational methylation state of histone lysine residues and modulate protein-protein interactions that regulate gene expression. UNC1215 has an IC50 of 20 nM and > 100-fold selectivity over 13 HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. UNC1215 showed a significant decrease in FRAP recovery (Fluorescence Recovery After Photobleaching) time below 1 microM in cells using GFP-L3MBTL3. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc,
Features and Benefits
UNC1215 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC,
This compound is a featured product for Gene Regulation research. Click here, to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.Other NotesUNC1215 has been expertly reviewed and recommended by the Chemical Probes Portal.ПараметрыQuality Level 100, assay ≥98% (HPLC) form powder color white to beige solubility DMSO: 5 mg/mL, clear storage temp. 2-8°C SMILES string O=C(N1CCC(N2CCCC2)CC1)C3=CC(NC4=CC=CC=C4)=C(C(N5CCC(N6CCCC6)CC5)=O)C=C3 InChI 1S/C32H43N5O2/c38-31(36-20-12-27(13-21-36)34-16-4-5-17-34)25-10-11-29(30(24-25)33-26-8-2-1-3-9-26)32(39)37-22-14-28(15-23-37)35-18-6-7-19-35/h1-3,8-11,24,27-28,33H,4-7,12-23H2 InChI key PQOOIERVZAXHBP-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
UNC1999
Empirical Formula (Hill Notation): C33H43N7O2 CAS Number: 1431612-23-5 Molecular Weight: 569.74 MDL number: MFCD26960958 PubChem Substance ID: 329825598 NACRES: NA.77
Кат. номер SML0778-5MG SML0778-25MG Packaging5, 25 mg in glass bottleBiochem/physiol ActionsThe polycomb repressive complex 2 (PRC2), which represses gene expression through methylation of histone H3 on lysine 27 (H3K27), contains either EZH1 or EZH2 as its catalytic subunit, with EZH1 being found in both dividing and non-dividing cells, whereas EZH2 is only found in actively dividing cells. UNC1999 is an orally bioavaliable selective inhibitor of both EZH2 and EZH1 lysine methyltransferases with IC50 < 10 nM for EZH2 and 45 nM for EZH1. UNC1999 potently inhibited both wild-type and mutant Y641N EZH2 methyltransferase activity with less than a 5-fold difference in potency, and selectively killed diffused large B cell lymphoma (DLBCL) cells bearing Y641 point mutations. It was selective for EZH2 and EZH1 over 15 other lysine, arginine and DNA methyltransferases. UNC1999 is competitive with the cofactor S-adenosylmethionine (SAM) and non-competitive with the peptide substrate. Because it inhibits both EZH2 and EZH1, UNC1999 has potential advantages over EZH2 selective inhibitors in the disease settings where both PRC2 – EZH2 and PRC2 – EZH1 contribute to the methylation of H3K27.
UNC2400 is the negative control for the active probe, UNC1999. To request a sample of the negative control from the SGC, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgcFeatures and BenefitsUNC1999 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.Other NotesUNC1999 has been expertly reviewed and recommended by the Chemical Probes Portal.ПараметрыQuality Level 100 assay ≥98% (HPLC) form powder color white to beige solubility DMSO: 15 mg/mL, clear storage temp. 2-8°C SMILES string CC(C)N1CCN(C2=NC=C(C3=CC4=C(C=NN4C(C)C)C(C(NCC5=C(CCC)C=C(C)NC5=O)=O)=C3)C=C2)CC1 InChI 1S/C33H43N7O2/c1-7-8-24-15-23(6)37-33(42)28(24)19-35-32(41)27-16-26(17-30-29(27)20-36-40(30)22(4)5)25-9-10-31(34-18-25)39-13-11-38(12-14-39)21(2)3/h9-10,15-18,20-22H,7-8,11-14,19H2,1-6H3,(H,35,41)(H,37,42) InChI key DPJNKUOXBZSZAI-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену
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