TP-472N

Empirical Formula (Hill Notation):	C19H18N2O2
CAS Number:	2080306-24-5
Molecular Weight:	306.36
MDL number:	MFCD30720894

Кат. номер

SML1933-5MG

SML1933-25MG

Biochem/physiol Actions
TP-472N is a negative control probe for TP-472,. TP-472 is a selective probe for bromodomain-containing proteins BRD9 and BRD7. The BRD9/7 probe was developed out of a collaborative effort by Takeda and the SGC, and is of a different chemotype from BRD9/7 probes previously available. TP-472 has a KD value of 33nM for BRD9 and 340nM for BRD7 by ITC, is >30 fold selective for BRD9 over all other bromodomain family members except BRD7, and is suitable for in vivo applications. The negative control TP-472N is inactive against other bromodomains (>20µM against BRD9). TP-472, the active BRD9/7 probe, is available from Sigma. To learn more about and purchase TP-472, click here,.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc,
Features and Benefits
TP-472N is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC,.
This compound is a featured product for Gene Regulation research. Click here, to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.

Quality Level	100,
assay	≥98% (HPLC)
form	powder
color	white to beige
solubility	DMSO: 15 mg/mL, clear
storage temp.	2-8°C
SMILES string	O=C(C)C1=CC(C2=CC=CC=C2OCC3CC3)=C4N=CC=CN41

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable