Bromosporine

Empirical Formula (Hill Notation):	C17H20N6O4S
Molecular Weight:	404.44
MDL number:	MFCD26142669
PubChem Substance ID:	329825627
NACRES:	NA.77

Кат. номер

SML0992-5MG

SML0992-25MG

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Bromodomains (BRDs) are protein-interaction modules that "read" -N-lysine acetylation motifs, such as those found in the N-terminal tails of histones. BRDs have been identified in chromatin-modifying enzymes (such as histone acetyltransferases (HATs)) as well as in transcription factors that regulate genes for cell cycle progression, signal transduction, apoptosis, and inflammation. Proteins containing bromodomains have been implicated in various diseases, such as cancers, inflammatory diseases and neurological diseases. Bromosporine is a broad spectrum BRD inhibitor. In HeLa cells, bromosporine accelerates FRAP recovery of BRD4 and CREBBP at 1µM. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc,
Features and Benefits
Bromosporine is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC,.
This compound is a featured product for Gene Regulation research. Click here, to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.

Quality Level	100,
assay	≥98% (HPLC)
form	powder
color	white to beige
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C
SMILES string	CC(C(NS(C)(=O)=O)=C1)=CC=C1C2=NN3C(C(NC(OCC)=O)=C2)=NN=C3C
InChI	1S/C17H20N6O4S/c1-5-27-17(24)18-15-9-14(21-23-11(3)19-20-16(15)23)12-7-6-10(2)13(8-12)22-28(4,25)26/h6-9,22H,5H2,1-4H3,(H,18,24)
InChI key	UYBRROMMFMPJAN-UHFFFAOYSA-N

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable