- Производитель:
- Sigma-Aldrich
MDL number: | MFCD00145892 |
Кат. номер |
T8535-.2ML |
T8535-100UL |
T8535-25UL |
T8535-.5ML |
Monoclonal Anti-β-Tubulin Isotype I + II (mouse IgG2b isotype) is derived from the JDR.3B8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice.
Specificity
The antibody specifically recognizes an epitope located on isotypes I and II of β-tubulin. No cross-reactivity with other tubulin isotypes is observed.
- immunoblot
- immunofluorescence technique
- immunohistochemistry.
Monoclonal Anti--Tubulin I+II antibody produced in mouse has been used in:
- enzyme linked immunosorbent assay (ELISA)
- immunohistochemistry
- western blotting
- immunoblotting
- dot blot
- immunocytochemistry
Biochem/physiol Actions
β-1 tubulin, also known as class VI or TUBB1, plays a vital role in platelet production and is considered to be a potential biomarker candidate for immune thrombocytopenia (ITP). Mutation in the gene leads to various neuronal migration disorders such as lissencephaly, pachygyria and polymicrogyria malformations. B2702 peptide binds to β-tubulin and inhibits natural killer (NK) cell cytotoxicity and it influences microtubule polymerization, which damages cytoskeleton organization and chaperone-like activity of tubulin. Tubulin β 2B class IIb (TUBB2B)/β-tubulin II plays a vital role in migration/organization and axon guidance processes. Mutation in β-tubulin gene is associated with the development of asymmetric polymicrogyria (PMG).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Quality Level | 200 |
biological source | mouse |
antibody form | ascites fluid |
antibody product type | primary antibodies |
clone | JDR.3B8, monoclonal |
contains | 15 mM sodium azide |
species reactivity | human, chicken, mouse, rat, bovine, pig |
packaging | antibody small pack of 25 µL |
application(s) | indirect ELISA: suitable","indirect immunofluorescence: suitable","microarray: suitable","western blot: 1:1,000 using a chicken fibroblast extract or a chicken brain microtubule proteins preparation |
isotype | IgG2b |
conjugate | unconjugated |
UniProt accession no. | Q13885,","Q9H4B7, |
shipped in | dry ice |
storage temp. | 20°C |
Gene Information | human ... TUBB1(81027), TUBB2A(7280), TUBB2C(10383) mouse ... Tubb1(545486), Tubb2a(22151), Tubb2c(227613) rat ... Tubb2(29212), Tubb2c(296554) |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point F | Not applicable |
Flash Point C | Not applicable |
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