- Производитель:
- Sigma-Aldrich
MDL number: | MFCD00164684 |
NACRES: | NA.41 |
Кат. номер |
M2320-25UL |
M2320-200UL |
M2320-100UL |
Monoclonal Anti-MAP2 (2a + 2b) (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with bovine microtubule associated protein 2 (MAP2).
Monoclonal Anti-MAP2 specificity was established by an immunoblot. The antibody localizes the high molecular weight forms of MAP2, namely MAP2a and MAP2b, but shows no reactivity with MAP2c. No crossreactivity is observed with MAP1, MAP5, tubulin, or tau (t).
Specificity
Monoclonal Anti-MAP2 antibody reacts with human, bovine, rat, mouse, Xenopus, salamander, and quail tissue or cells by immunocytochemical techniques utilizing either a fluorescent or peroxidase label, or by immunohistochemistry.
Mouse monoclonal clone AP-20 anti-MAP2 (2a+2b) antibody is used to tag MAP2 for detection and quantitation by Western blotting and immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of MAP2a and MAP2b in cell signaling especially in neural tissues.
Biochem/physiol Actions
Microtubule associated protein 2 (MAP2) is known to promote microtubule assembly and to form side arms on microtubules. It also interacts with neurofilaments, actin and other elements of the cytoskeleton. MAP2 is degraded by a cathepsin D like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in others. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin and other elements of the cytoskeleton.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Quality Level | 200 |
biological source | mouse |
antibody form | purified immunoglobulin |
antibody product type | primary antibodies |
clone | AP-20, monoclonal |
form | buffered aqueous solution |
mol wt | apparent mol wt 280 kDa |
species reactivity | Xenopus, bovine, human, mouse, rat, aquatic salamander, quail |
packaging | antibody small pack of 25 µL |
concentration | ~2 mg/mL |
application(s) | immunocytochemistry: suitable","microarray: suitable","western blot: 1-3 µg/mL using rat brain preparation or rat cerebral cortex extract |
isotype | IgG1 |
conjugate | unconjugated |
UniProt accession no. | P11137, |
shipped in | dry ice |
storage temp. | 20°C |
Gene Information | human ... MAP2(4133) mouse ... Mtap2(17756) rat ... Map2(25595) |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point F | Not applicable |
Flash Point C | Not applicable |
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