Anti-TSLP Receptor Antibody, clone 1A6

eCl@ss:

32160702

Кат. номер

MABF2042-25UG

MABF2042-100UG

Cytokine receptor-like factor 2 (UniProt: Q9HC73; also known as Cytokine receptor-like 2, IL-XR, Thymic stromal lymphopoietin protein receptor, TSLP receptor) is encoded by the CRLF2 (also known as CRL2, ILXR, TSLPR) gene (Gene ID: 64109) in human. TSLP receptor is a single-pass type I membrane protein that serves as a receptor for thymic stromal lymphopoietin. It forms a functional complex with TSLP and IL7R to stimulate cell proliferation via activation of STAT3 and STAT5. It is primarily expressed in dendrites and monocytes and its expression has also been reported in heart, skeletal muscle, kidney and liver. Its levels are up-regulated in activated peripheral monocytes and THP-1 cells. TSLP receptor is synthesized with a signal peptide (aa 1-21), which is subsequently cleaved off in the mature form. It contains an extracellular domain (aa 23-231), a transmembrane domain (aa 232-252), and a cytoplasmic domain (aa 253-371). It also has a WSXWS motif (aa 200-204) that is essential for proper protein folding and efficient intracellular transport and cell-surface binding. In addition, its Box 1 motif (aa 261-269) is reported to be important for its association with JAKs. Three isoforms of TSLP receptors have been described that are produced by alternative splicing.
Specificity
Clone 1A6 specifically detects human TSLP receptor protein. It targets an epitope with in the extracellular domain.
Fc-fusion protein of ectodomain region of human TSLP receptor protein.
Epitope: extracellular domain
Anti-TSLP Receptor, clone 1A6, Cat. No. MABF2042, is a mouse monoclonal antibody that detects TSLP receptor and has been tested for use in Flow Cytometry.
Research Category
Inflammation & Immunology
Quality
Evaluated by Flow Cytometry in one million THP-1 monocytic peripheral blood cells.
Flow Cytometry Analysis: 1 µg of this antibody detected TSLP Receptor in one million THP-1 monocytic peripheral blood cells.
Target description
42.01 kDa calculated.
Physical form
Format: Purified
Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G purified
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source	mouse
antibody form	purified immunoglobulin
antibody product type	primary antibodies
clone	1A6, monoclonal
species reactivity	human
packaging	antibody small pack of 25 µg
application(s)	flow cytometry: suitable
isotype	IgG2a
NCBI accession no.	NP_071431.2,
UniProt accession no.	Q9HC73,

WGK Germany	WGK 1
Flash Point F	Not applicable
Flash Point C	Not applicable