Anti-TES antibody ,Mouse monoclonal

NACRES:

NA.41

Кат. номер

SAB4200020-25UL

SAB4200020-200UL

Monoclonal Anti-TES (mouse IgG3 isotype) is derived from the hybridoma TES75 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Testin LIM domain protein (TES) comprises cysteine-rich zinc-binding motifs called LIM domains and is a component of focal adhesions. TES gene is mapped to a common fragile site on chromosome 7q31.2 is designated as FRA7G.
Specificity
Monoclonal Anti-TES recognizes human, monkey, bovine, and mouse TES
Anti-TES antibody, mouse monoclonal may be used in immunoblotting.
Biochem/physiol Actions
Testin LIM domain protein (TES), a putative tumor-suppressor gene, is essential for motility and is key for the tumor cell anchorage and metastasis. TES mRNA expression is found in several cancer-derived cell lines, particularly hematopoietic, breast and ovarian cancer cell lines as well as in primary tumors. This was correlated with methylation of TES CpG island. Furthermore, TES gene knockout revealed its role as a tumor suppressor gene as well as in actin stress fibre organization.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Quality Level	200
biological source	mouse
antibody form	purified from hybridoma cell culture
antibody product type	primary antibodies
clone	TES75, monoclonal
form	buffered aqueous solution
mol wt	antigen ~48 kDa
species reactivity	mouse, human, bovine, monkey
packaging	antibody small pack of 25 µL
concentration	~1.5 mg/mL
application(s)	western blot: 0.5-1.0 µg/mL using whole extract of mouse thymus
isotype	IgG3
conjugate	unconjugated
UniProt accession no.	Q9UGI8,
shipped in	dry ice
storage temp.	20°C
Gene Information	human ... TES(26136) mouse ... Tes(21753)

RIDADR	NONH for all modes of transport
Flash Point F	Not applicable
Flash Point C	Not applicable