Anti-Snurportin 1 (C-terminal) antibody produced in rabbit

NACRES:

NA.41

Кат. номер

SAB4200063-25UL

SAB4200063-200UL

Snurportin 1 contains an N-terminal importin β binding (IBB) motif, 2,2,7-trimethylguanosine (TMG) cap-binding domain, an ill-defined region and a Cterminal m3Gcap-binding region. The SNUPN gene is mapped on the human chromosome at 15q24.2.
Specificity
Anti-Snurportin 1 recognizes human snurportin 1.
Anti-Snurportin 1 (C-terminal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Snurportin 1 mediates the nuclear import of 5′2,2,7terminal trimethylguanosine (m3G)-capped uridine-rich small nuclear RNPs (U snRNPs), an important step in the maturation of the spliceosome. This protein binds with importin β that mediates the interaction with the nuclear pore complex (NPC). It also interacts with m3G-cap but not with 5′terminal 7monomethylguanosine (m7G)-cap structures and chromosomal maintenance 1 (Crm1)/exportin 1. Snurportin 1 was found to accumulate in Cajal bodies after the import of U2 but not U1 snRNPs.
Physical form
Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source	rabbit
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	antigen ~41 kDa
packaging	antibody small pack of 25 μL
concentration	~1.0 mg/mL
application(s)	immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human Snurportin 1, western blot: 1-2 μg/mL using lysates of HEK-293T cells over expressing human Snurportin 1
conjugate	unconjugated
shipped in	dry ice
storage temp.	−20°C
Gene Information	human ... SNUPN(10073)

RIDADR	NONH for all modes of transport
Flash Point F	Not applicable
Flash Point C	Not applicable