- Производитель:
- Sigma-Aldrich
MDL number: | MFCD07784768 |
NACRES: | NA.41 |
Кат. номер |
S8447-100UL |
S8447-200UL |
S8447-25UL |
Sirtuin 2 (SIRT2) is a cytoplasmic protein, which is part of the sirtuin family of proteins. SIRT2 colocalizes with microtubules. This gene is located on human chromosome 19q13.2.
Sirt2 is an NAD+-dependent tubulin deacetylase. Two Sirt2 isoforms exist as the result of alternative splicing. Sirt2 is overexpressed during mitosis and is multiply phosphorylated at the G2/M transition of the cell cycle, indicating that it plays a role in the control of mitotic exit in the cell cycle. Although Sirt2 resides predominantly in the cytoplasm, it becomes enriched in the nucleus during the cell cycle where it is associated with mitotic structures. Sirt2 was found to be an oligodendroglial protein that affects cell differentiation through deacetylating α-tubulin.
Anti-Sirt2 antibody has been used in western blotting and immunofluorescence.
Biochem/physiol Actions
Sirtuin 2 (SIRT2) maintains the integrity of the genome. Inhibition of SIRT2 can lead to neuroprotection in cellular and invertebrate models of Huntington′s disease. SIRT2 can deacetylate lys40 of α-tubulin both in vitro and in vivo. Knockdown of SIRT2 by small interfering RNA (siRNA) leads to tubulin hyperacetylation.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
biological source | rabbit |
Quality Level | 200 |
antibody form | affinity isolated antibody |
antibody product type | primary antibodies |
clone | polyclonal |
form | buffered aqueous solution |
mol wt | antigen 37:43 kDa (rat)","antigen 43 kDa (human) |
species reactivity | mouse, human, rat |
packaging | antibody small pack of 25 µL |
application(s) | immunoprecipitation (IP): 2-5 µg using extract of COS7 cells or 293 cells expressing recombinant human SIRT2 protein.","indirect immunofluorescence: 5-10 µg/mL using human HeLa cells.","western blot: 1-2 µg/mL using whole extracts of mouse and rat brain. |
conjugate | unconjugated |
UniProt accession no. | Q8IXJ6, |
shipped in | dry ice |
storage temp. | 20°C |
Gene Information | human ... SIRT2(22933) mouse ... Sirt2(64383) rat ... Sirt2(361532) |
Personal Protective Equipment | Eyeshields,, Gloves,, multi-purpose combination respirator cartridge (US), |
RIDADR | NONH for all modes of transport |
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