Anti-SDCBP (N-terminal) antibody produced in rabbit

NACRES:

NA.41

Кат. номер

S1576-25UL

S1576-200UL

Syndecan binding protein (SDCBP) is also named as syntenin and melanoma differentiation associated gene-9 (MDA-9) contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. SDCBP is located to membrane associated adherens junctions and focal adhesions. It is present in the endoplasmic reticulum and nucleus. SDCBP gene is mapped to human chromosome 8q12.1 and has 9 exons and is expressed in fetal kidney, liver, lung and brain.
Specificity
Anti-SDCBP (N-terminal) recognizes human SDCBP.
Anti-SDCBP (N-terminal) antibody produced in rabbit may be used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

Biochem/physiol Actions
Syndecan binding protein (SDCBP) might distress the organization of cytoskeletal-membrane and the stimulation of transcription factors. It may also affect cell adhesion and protein trafficking. SDCBP promotes metastasis in human melanoma cells by activating c-Src. Alternative splicing results in multiple transcript variants encoding different isoforms. Syntenin enables the recruitment of ubiquitinated proteins to its transmembrane partners by interacting with ubiquitin through is C- and N-terminal regions. It plays a key role in synapses formation and maturation. Upregulation of syntenin blocks human immunodeficiency virus-1 (HIV-1) production and HIV-mediated cell fusion. Depletion of this gene enhances the entry of HIV-1.
Physical form
Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source	rabbit
Quality Level	200
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	antigen ~30 kDa
species reactivity	human
packaging	antibody small pack of 25 µL
concentration	~1.0 mg/mL
application(s)	immunoprecipitation (IP): 5-10 µg using lysates of human HeLa cells","indirect immunofluorescence: 10-20 µg/mL using human HeLa cells","western blot: 2-4 µg/mL using whole extracts of human HEK-293T cells
conjugate	unconjugated
UniProt accession no.	O00560,
shipped in	dry ice
storage temp.	20°C
Gene Information	human ... SDCBP(6386)

WGK Germany

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