Anti-Resistin

eCl@ss:	32160702
NACRES:	NA.41

Кат. номер

AB3371-I

AB3371-I-25UL

Resistin (UniProt: Q9HD89; also known as Adipose tissue-specific secretory factor, ADSF,C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, Cysteine-rich secreted protein FIZZ3) is encoded by the RETN (also known as FIZZ3, HXCP1, RSTN) gene (Gene ID: 56729) in rat. Resistin is a dilsulfide-linked homodimeric hormone secreted by the white adipose tissue. It is widely expressed, with strong expression in lung, bone marrow, and breast tissue. Resistin (resistance to insulin) was originally named for its ability to resist or interfere with the action of insulin. It has been linked to the development of atherosclerosis and cardiovascular diseases, non-alcoholic fatty liver disease, rheumatic disease, malignancy, asthma, inflammatory bowel disease and chronic kidney disease. It suppresses the ability of insulin to stimulate glucose uptake into adipose cells and is a key molecule linking obesity to diabetes. Circulating resistin levels are shown to be elevated in diet-induced and genetic forms of obesity and administration of anti-resistin antibody is shown to improve blood glucose levels and insulin action in mice with diet-induced obesity. Two isoforms of resistin have been described that are generated by alternative splicing. (Ref.: Jamaluddin MS et al (2012). Br J Pharmacol. 165(3); 622-632; Steppan, CM et al. (2001). Nature 409 (6818); 307-312).
Specificity
This rabbit polyclonal antibody detects Resistin in rat tissues. It targets an epitope within 17 amino acids from the N-terminal region.
KLH-conjugated linear peptide corresponding to 17 amino acids from the N-terminal region of rat resistin.
Epitope: N-terminus
Anti-Resistin Antibody, Cat. No. AB3371-I, is a rabbit polyclonal antibody that detects rat resistin and has been tested for use in Western Blotting.
Research Category
Inflammation & Immunology
Quality
Evaluated by Western Blotting in Resistin Recombinant Protein.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected recombinant rat resistin.
Target description
~12 kDa observed; 11.42 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physical form
Affinity Purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source	rabbit
Quality Level	100
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
purified by	affinity chromatography
species reactivity	rat
packaging	antibody small pack of 25 µL
application(s)	western blot: suitable
NCBI accession no.	NP_001180303.1,
UniProt accession no.	Q9HD89,
shipped in	ambient