Anti-PLAGL1 antibody produced in rabbit

NACRES:

NA.41

Кат. номер

L1670-200UL

L1670-25UL

The gene PLAGL1 (pleiomorphic adenoma-like protein 1), PLAGL2 and PLAG1 form a subfamily of PLAG family of zinc finger proteins that recognize DNA and RNA. The three members share similarity at the amino-terminal, but are functionally different, varying in their DNA binding capacities. The gene is mapped to human chromosome 6q24.2, a region implicated in several cancers.
Specificity
Anti-PLAGL1 specifically recognizes human PLAGL1.
Anti-PLAGL1 antibody produced in rabbit may be used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
PLAGL1 gene expression is downregulated in a methylation-sensitive manner. PLAGL1 is an imprinted gene that regulates an imprinted gene network involved in embryonic growth control.
The maternally-imprinted gene, PLAGL1 (pleiomorphic adenoma-like protein 1), functions as an oncogene as well as a tumor suppressor depending on the cell context. It has been found to exhibit anti-proliferative properties and regulate apoptosis and cell-cycle arrest via p53.
Physical form
Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source	rabbit
Quality Level	200
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	antigen ~50 kDa
species reactivity	human
packaging	antibody small pack of 25 µL
concentration	~1.0 mg/mL
application(s)	indirect immunofluorescence: 0.5-1 µg/mL using paraformaldehyde fixed HEK-293T cells over expressing human PLAGL1","western blot: 1-2 µg/mL using using lysates of HEK-293T cells over expressing human PLAGL1
conjugate	unconjugated
UniProt accession no.	Q9UM63,
shipped in	dry ice
storage temp.	20°C
Gene Information	human ... PLAGL1(5325)

WGK Germany

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