Anti-GABARAPL2

eCl@ss:	32160702
NACRES:	NA.41

Кат. номер

ABC227-100UL

ABC227-25UL

Gamma-aminobutyric acid receptor-associated protein-like 2 (UniProt: P60520; also known as GABA(A) receptor-associated protein-like 2, Ganglioside expression factor 2, GEF-2, General protein transport factor p16, Golgi-associated ATPase enhancer of 16 kDa, GATE-16, MAP1 light chain 3-related protein) is encoded by the GABARAPL2 (also known as FLC3A, GEF2) gene (Gene ID: 11345) in human. GEF-2 is a momomeric ubiquitin-like modifier protein of ATG8 family that is involved in intra-Golgi traffic. It is shown to modulate intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF, which in turn stimulates the association with GOSR1. GEF-2 is also involved in autophagy and plays a role in mitophagy, which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level. It is ubiquitously expressed and higher expressions are observed in the brain, heart, prostate, ovary, spleen and skeletal muscle. Low expression levels are observed in lung, thymus, and small intestine. In the precursor molecule the peptide bond between aa 116 and 117 is cleaved off by ATG4 to generate mature protein.
Specificity
This rabbit polyclonal antibody detects GABA(A) receptor-associated protein-like 2 (GABARAPL2) in human cells.
GST-tagged full length human recombinant GABA(A) receptor-associated protein-like 2 (GABARAPL2).
Anti-GABARAPL2, Cat. No. ABC227, is a rabbit polyclonal antibody that detects Gamma-aminobutyric acid receptor-associated protein-like 2 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected GABARAPL2 in human cerebellum and human prostate tissue sections.
Quality
Evaluated by Western Blotting in Raji membrane extract.
Western Blotting Analysis: A 1:500 dilution of this antibody detected GABARAPL2 in Raji membrane extract.
Target description
~ 14 kDa observed; 13.67 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physical form
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide/.
Concentration: Please refer to lot specific datasheet.

biological source	rabbit
antibody form	purified antibody
antibody product type	primary antibodies
clone	polyclonal
purified by	affinity chromatography
species reactivity	human
packaging	antibody small pack of 25 µL
application(s)	immunohistochemistry: suitable (paraffin)","western blot: suitable
UniProt accession no.	P60520,
Gene Information	human ... GABARAPL2(11345)