- Производитель:
- Sigma-Aldrich
NACRES: | NA.41 |
Кат. номер |
SAB4200820-25UL |
SAB4200820-100UL |
Monoclonal Anti-Fetuin A (mouse IgM isotype) is derived from the Fet A-M hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a BALB/C mouse immunized with a synthetic peptide corresponding to the internal region of human AHSG (Fetuin A), conjugated to KLH as immunogen. Fetuin A is a 64 kDa protein, predominantly localized to the blood.
Specificity
Monoclonal Anti-Fetuin A specifically recognizes Fetuin A from human plasma.
Biochem/physiol Actions
Fetuin A is consider to be a negative acute-phase reactant and its serum concentration decreases in response to inflammation, compared with normal levels. In addition, it acts as a mineral chaperone to facilitate the transport and removal of potentially proinflammatory and procalcific cargo (waste).Fetuin A plays a major role in numerous diseases and pathophysiological conditions involved with calcium metabolisms.
Fetuin A is a secreted calcium-regulatory glycoprotein produced by liver hepatocytes. It is cleaved into two chains bound by disulphide bonds and inhibits ectopic CaxPO4 ion precipitation and vascular calcification.
Reduction in the serum fetuin might indicate coronary artery disease. Fetuin is also implicated in insulin resistance and metabolic syndrome. Increased levels of fetuin A is observed in non-alcoholic fatty liver disease.
Physical form
Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
Storage and Stability
For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
biological source | mouse |
antibody form | purified from hybridoma cell culture |
antibody product type | primary antibodies |
clone | FetA-M, monoclonal |
species reactivity | human |
packaging | antibody small pack of 25 µL |
concentration | ~1 mg/mL |
application(s) | immunoblotting: 2-4 µg/mL using Human serum |
isotype | IgM |
conjugate | (KLH) |
UniProt accession no. | P02765, |
shipped in | dry ice |
storage temp. | 20°C |
Gene Information | human ... AHSG(197) |
WGK Germany | WGK 1 |
Flash Point F | Not applicable |
Flash Point C | Not applicable |
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