- Производитель:
- Sigma-Aldrich
eCl@ss: | 32160702 |
NACRES: | NA.41 |
Кат. номер |
7-662 |
7-662-25UG |
7-662-100UG |
This protein is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. In mouse, ERR alpha is expressed in many adult and embryonic tissues (particularly at the onset of ossification) as well as in several osteoblast cell lines. ERR alpha expression has been documented in mouse in brain, spinal cord, pituitary gland and heart.
Specificity
Recognizes Estrogen-related Receptor α.
Transcription Factors
Research Category
Epigenetics & Nuclear Function
Anti-Estrogen-related Receptor α Antibody is a Rabbit Polyclonal Antibody for detection of Estrogen-related Receptor α also known as ERR alpha & has been tested in EMSA, IHC, IP & WB.
Quality
Routinely evaluated by immunoblot on RIPA lysates from HeLa nuclear extracts.
Target description
53 kDa
Physical form
Format: Purified
Protein A Purified rabbit IgG in a solution of 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.135M NaCl, and 0.035% sodium azide as a preservative.
Protein A purified
Storage and Stability
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Analysis Note
Control
Positive Control Included: HeLa Nuclear Extract (12-309).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
biological source | rabbit |
Quality Level | 100 |
antibody form | purified antibody |
antibody product type | primary antibodies |
clone | polyclonal |
species reactivity | mouse, rat, human, hamster |
packaging | antibody small pack of 25 µg |
Торговая марка | Upstate® |
application(s) | electrophoretic mobility shift assay: suitable","immunohistochemistry: suitable","immunoprecipitation (IP): suitable","western blot: suitable |
isotype | IgG |
NCBI accession no. | NM_000125.2, |
UniProt accession no. | P03372, |
shipped in | ambient |
Gene Information | human ... ESR1(2099) |
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