- Производитель:
- Sigma-Aldrich
Кат. номер |
SAB4200837-25UL |
SAB4200837-100UL |
Specificity
Monoclonal Anti-DDX6 antibody specifically recognizes DDX6 from human, mouse, monkey, canine and bovine origin.
Biochem/physiol Actions
DDX6 is considered to be a P-bodies marker due to its mediating role between translational repression and P-bodies formation and toits interaction with Ago2 and the RISC complex that also mediates translational silencing by miRNAs.1-4 Viruses like Hepatitis C virus (HCV) or West Nile virus (WNV) utilize the host cell DDX6 to promote virus infection by recruiting it to the viral replication sites where it is involved in stabilization of the viral genome and the shift between translation and replication.2,5-6DDX6 was reported to be overexpressed in colorectal adenocarcinomas, gastric cancer and in most malignant cell lines.7-9 It was suggested that DDX6 acted as an upstream cancerous enhancer through RNA-binding of HER2 and FGFR2 mRNAs that positively regulates post-transcriptional processes in cancer cells.7
Physical form
Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
Storage and Stability
For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
biological source | mouse |
antibody form | purified from hybridoma cell culture |
antibody product type | primary antibodies |
clone | DDX6-34, monoclonal |
species reactivity | mouse, dog, rat, monkey, human, bovine |
packaging | antibody small pack of 25 µL |
concentration | ~1 mg/mL |
application(s) | immunoblotting: 1-2 µg/mL using human HeLa whole cell extract.","immunofluorescence: 10-20 µg/mL using human U-2-OS cells. |
isotype | IgG1 |
UniProt accession no. | P26196, |
shipped in | dry ice |
storage temp. | 20°C |
Gene Information | Monkey ... DDX6(101053064) bovine ... DDX6(513906) dog ... DDX6(479414) human ... DDX6(1656) mouse ... DDX6(13209) rat ... DDX6(500988) |
Flash Point F | Not applicable |
Flash Point C | Not applicable |
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