Anti-Coronin-1C (C-terminal)

NACRES:

NA.41

Кат. номер

SAB4200077-25UL

SAB4200077-200UL

Coronin 1C (CORO1C) is encoded by the gene mapped to human chromosome 12q24.1. The encoded protein belongs to coronin-like family of proteins. CORO1C consists of 474 amino acids and is ubiquitously expressed in human tissues. CORO1C contains conserved five WD repeats in its N-terminal end and a coiled-coil motif in its C-terminal end.The protein is mainly present at the sites of active actin dynamics including lamellipodia and membrane ruffles.
Specificity
Anti-Coronin-1A (C-terminal) specifically recognizes human, mouse, and rat coronin-1A.
Biochem/physiol Actions
Coronin 1C (CORO1C) plays a vital role in cytokinesis, motility and signal transduction. It is also implicated in regulation of various cellular processes such as cell proliferation, migration, invadopodia formation and invasion in glioblastoma cells. CORO1C acts as a predictive biomarker for hepatocellular carcinoma (HCC) invasive behavior. The encoded protein negatively regulates cell-matrix adhesion and intestinal epithelial cells (IECs) migration via FAK-mediated signaling.
Physical form
Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	antigen ~57 kDa
species reactivity	human, mouse, rat
packaging	antibody small pack of 25 µL
concentration	~1.5 mg/mL
application(s)	western blot: 1.5-3.0 µg/mL using Jurkat cell lysates, or lysates of mouse brain (S1 fraction) or rat spleen (S1 fraction)
conjugate	unconjugated
UniProt accession no.	P31146,
shipped in	dry ice
storage temp.	20°C
Gene Information	human ... CORO1A(11151)

RIDADR	NONH for all modes of transport
Flash Point F	Not applicable
Flash Point C	Not applicable