Anti-Calcitonin Gene Related Peptide antibody produced in rabbit

MDL number:	MFCD00162203
NACRES:	NA.41

Кат. номер

C8198-.2ML

C8198-25UL

Calcitonin Gene Related Peptide (CGRP), a cyclic peptide, belongs to a small family of peptides encoded by the calcitonin/CGRP gene complex. The calcitonin/CGRP gene complex consists of at least two genes, encoding for two forms of CGRP: -CGRP (CGRP-I) and -CGRP (CGRP-II). CGRP is synthesized and co-localized with calcitonin in the parafollicular C-cells of the thyroid gland and medullary thyroid carcinoma. It is principally considered a neuropeptide widely distributed in the central and peripheral nervous systems.
Specificity
Anti-Calcitonin Gene Related Peptide reacts with CGRP (rat). Cross-reactivity is observed with CGRP (human) and β-CGRP (human).
CGRP-KLH
Anti-Calcitonin Gene Related Peptide antibody produced in rabbit has been used in:

• dot blot immunoassay
• fluorescent labeling
• confocal microscopy
• immunohistofluorescence
• epifluorescence imaging

Anti-Calcitonin Gene Related Peptide antibody produced in rabbit was used for immunohistochemistry of trigeminal ganglia cell cultures at a dilution of 1:200 and for immunocytochemistry of mouse lung slices at a dilution of 1:500.
Biochem/physiol Actions
CGRP is thought to act as a neurotransmitter or neuromodulator, particularly in the regulation of autonomic (e.g., cardiovascular, respiratory, gastrointestinal, taste, food intake and sleep) and limbic functions. CGRP is probably involved with substance P in mediating neurogenic inflammation and transmission of pain stimuli via the peripheral nervous system.
Calcitonin Gene Related Peptide is a G protein-coupled receptor that binds receptor-activity-modifying proteins (RAMP)1, -2 and -3. CLR has been implicated in conditions such as obesity, diabetes, osteoporosis, migraine and cardiovascular disease.
Quantity
delipidized
Physical form
Supplied as a liquid containing 0.1% sodium azide as a preservative
Storage and Stability
For continuous use, store 2-8°C. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing, or storage in "frost-free"freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source	rabbit
Quality Level	200
antibody form	whole antiserum
antibody product type	primary antibodies
clone	polyclonal
contains	15 mM sodium azide
species reactivity	rat
packaging	antibody small pack of 25 µL
application(s)	ELISA: suitable","dot blot: 1:10,000","immunohistochemistry: 1:8,000 using 4% paraformaldehyde perfusion-fixed, frozen sections of rat brain
conjugate	unconjugated
UniProt accession no.	P06881,
shipped in	dry ice
storage temp.	20°C
Gene Information	rat ... Calca(24241)

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable