Anti-CACYBP antibody,Mouse monoclonal

MDL number:	MFCD04040491
NACRES:	NA.41

Кат. номер

SAB4200187-25UL

SAB4200187-200UL

Monoclonal Anti-CACYBP (mouse IgG1 isotype) is derived from the hybridoma CABP7 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant fusion protein. The protein is a human ortholog of mouse calcyclin (S100A6)-binding protein and an element of novel ubiquitin ligase complex.
The gene CACYBP (calcyclin binding protein) is mapped to human chromosome 1q25.1. It is widely expressed in human tissues.
Specificity
Monoclonal Anti-CACYBP recognizes human, dog, bovine, and monkey CACYBP.
Anti-CACYBP antibody, Mouse monoclonal is suitable for immunoblotting.
Biochem/physiol Actions
CACYBP (calcyclin binding protein) is a part of the ubiquitination machinery and is involved in the degradation of β-catenin. It can interact with S100, SIAH1 (seven in absentia homolog 1) and SKP1 (S-phase kinase-associated protein 1). CACYBP is involved in proliferation, differentiation, multidrug resistance and tumorigenicity. It can work as an oncogene and as a tumor suppressor. In glioma cells, CACYBP enhances the cellular proliferation.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Storage and Stability
Store at 20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source	mouse
antibody form	purified from hybridoma cell culture
antibody product type	primary antibodies
clone	CABP7, monoclonal
form	buffered aqueous solution
mol wt	~27 kDa
species reactivity	monkey, canine, bovine, human
packaging	antibody small pack of 25 µL
concentration	~1.0 mg/mL
application(s)	western blot: 2-4 µg/mL using SH-SY5Y, HeLa, COS-7 and MDCK total cell extracts
isotype	IgG1
conjugate	unconjugated
UniProt accession no.	Q9HB71,
shipped in	dry ice
storage temp.	20°C
Gene Information	human ... CACYBP(27101)

RIDADR	NONH for all modes of transport
Flash Point F	Not applicable
Flash Point C	Not applicable