Anti--Amyloid (13-28) antibody, Mouse monoclonal

MDL number:	MFCD07370937
NACRES:	NA.41

Кат. номер

A8978-200UL

A8978-25UL

Amyloids are insoluble protein aggregates consisting of misfolded proteins and peptides. Amyloid deposition are associated with multiple neurodegenerative disorders.
The -amyloid precursor protein (APP) is cleaved sequentially by the proteolytic enzymes -secretase (BACE1) and -secretase to produce -amyloid (A) peptides with the A1-42 and the A1-40 forms being the most prevalent. Secreted A peptides are degraded either via a re-uptake mechanism followed by endosomal degradation, or by an extracellular insulin degrading enzyme. Extracellular accumulation of A leads to the formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, which is the hallmark of Alzheimers disease (AD).
Monoclonal Anti -Amyloid [13-28] recognizes the -Amyloid peptide. The antibody epitope resides within amino acids 20-23.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper),
Mouse Monoclonal Anti-β-Amyloid (13-28) antibody can be used for immunoblotting assays at 1:5,000. The antibody can also be used for IHC, immunoprecipitation,fluorescence infrared spectroscopy and enzyme immunoassays (02-0.4μg/ml).
Physical form
Filtered solution in 0.01 M phosphate buffered saline, pH 7.4.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Quality Level	200
biological source	mouse
antibody form	purified immunoglobulin
antibody product type	primary antibodies
clone	BAM90.1, monoclonal
form	buffered aqueous solution
species reactivity	human
packaging	antibody small pack of 25 µL
concentration	~2 mg/mL
application(s)	enzyme immunoassay: 0.2-0.4 µg/mL using amyloid -protein","immunohistochemistry: suitable","immunoprecipitation (IP): suitable","western blot: suitable
isotype	IgG1
conjugate	unconjugated
UniProt accession no.	P05067,
shipped in	dry ice
storage temp.	20°C
Gene Information	human ... APP(351)

Personal Protective Equipment	Eyeshields,, Gloves,
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable