- Производитель:
- Sigma-Aldrich
MDL number: | MFCD02685921 |
NACRES: | NA.41 |
Кат. номер |
H0913-25UL |
H0913-200UL |
Packaging
200 μL in glass bottle
Biochem/physiol Actions
Acetyl-Histone H3 hav Acetylation of lysine residues within these N-terminal domains of histones by histone acetyl-transferase (HATs), including Gcn5p, PCAF, p300/CBP and TAFII250 is associated with transcriptional activation. This modification results in remodeling of the nucleosome structure into an open conformation more accessible to transcription complexes. Conversely, histone deacetylation by histone deacetylase (HDACs) is associated with transcription repression reversing the chromatin remodeling process. In most species, histone H3 is primarily acetylated at lysine 9, 14, 18, and 23. Acetylation at lysine 9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Acetylation of specific lysines in histone H3 is also associated with processes apart from transcription. During DNA replication, new histones are rapidly synthesized and assembled into replicated DNA. Histones H3 and H4 are brought to replicating chromatin in a pre-acetylated state that turns into a de-acetylated state after replication is completed and the newly assembled chromatin matures.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Quality Level | 200 |
biological source | mouse |
antibody form | purified immunoglobulin |
antibody product type | primary antibodies |
clone | AH3-120, monoclonal |
form | buffered aqueous solution |
mol wt | antigen ~17 kDa |
species reactivity | rat, Drosophila, chicken, bovine, mouse, Caenorhabditis elegans, human, frog |
packaging | antibody small pack of 25 µL |
concentration | ~2 mg/mL |
application(s) | immunocytochemistry: suitable","indirect ELISA: suitable","microarray: suitable","western blot: 1-2 µg/mL using whole cell extract of mouse fibroblasts 3T3 cell line treated with sodium butyrate |
isotype | IgG1 |
conjugate | unconjugated |
UniProt accession no. | P68431, |
shipped in | dry ice |
storage temp. | 20°C |
Gene Information | human ... H3F3A(3020), H3F3B(3021), HIST1H3A(8350), HIST1H3B(8358), HIST1H3C(8352), HIST1H3D(8351), HIST1H3E(8353), HIST1H3F(8968), HIST1H3G(8355), HIST1H3H(8357), HIST1H3I(8354), HIST1H3J(8356), HIST2H3A(333932), HIST2H3C(126961), HIST3H3(8290) mouse ... H3f3a(15078), H3f3b(15081), Hist1h3a(360198), Hist1h3b(319150), Hist1h3c(319148), Hist1h3d(319149), Hist1h3e(319151), Hist1h3f(260423), Hist1h3g(97908), Hist1h3h(319152), Hist1h3i(319153), Hist2h3b(319154), Hist2h3c1(15077), Hist2h3c2(97114) rat ... H3f3b(117056) |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
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