Amitriptyline hydrochloride
Empirical Formula (Hill Notation): | C20H23N · HCl |
CAS Number: | 549-18-8 |
Molecular Weight: | 313.86 |
EC Number: | 208-964-6 |
MDL number: | MFCD00012537 |
PubChem Substance ID: | 329823361 |
NACRES: | NA.24 |
Кат. номер |
PHR1384-1G |
PHR1384-1G-PW |
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Amitriptyline hydrochloride is a drug, and a tricyclic antidepressant with anticholinergic activity. It is widely used in combination with chlordiazepoxide 7-chloro-2-(methyl-amino)-5-phenyl-3H-1,4-benzodiazepine-4-oxide for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Amitriptyline hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and reversed-phase high-performance liquid chromatography.
Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high
in vitro affinity for 1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
This Certified Reference Material (CRM) is produced and certified in accordance with
ISO 17034 and
ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA1640 in the slot below. This is an example certificate only and may not be the lot that you receive.
Quality Level | 300 |
grade | certified reference material, pharmaceutical secondary standard |
form | neat |
CofA | current certificate can be downloaded |
application(s) | HPLC: suitable, gas chromatography (GC): suitable |
Featured Industry | Pharmaceutical (small molecule) |
format | neat |
pharmacopeia traceability | traceable to BP 16, traceable to PhEur Y0000563, traceable to USP 1029002 |
SMILES string | Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13 |
InChI | 1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H |
InChI key | KFYRPLNVJVHZGT-UHFFFAOYSA-N |
Gene Information | human ... SLC6A2(6530), SLC6A4(6532) |
pictograms | GHS06,GHS08,GHS09 |
signalword | Danger |
hcodes | H301 - H319 - H361d - H410 |
pcodes | P201 - P273 - P301 + P310 + P330 - P305 + P351 + P338 |
RIDADR | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all |
WGK Germany | WGK 3 |
Flash Point F | Not applicable |
Flash Point C | Not applicable |