Adapalene
Empirical Formula (Hill Notation): | C28H28O3 |
CAS Number: | 106685-40-9 |
Molecular Weight: | 412.52 |
MDL number: | MFCD03106112 |
PubChem Substance ID: | 329823363 |
NACRES: | NA.24 |
Кат. номер |
PHR1388-500MG |
PHR1388-500MG-PW |
Adapalene is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Adapalene may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Retinoic acid analogue that is a RAR and RAR agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RAR, RAR, RAR and RXR receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cells
in vitro. Displays comedolytic activity. Its unique pharmacological properties make it superior to other retinoids for the treatment of acne.
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
This Certified Reference Material (CRM) is produced and certified in accordance with
ISO 17034 and
ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3530 in the slot below. This is an example certificate only and may not be the lot that you receive.
Quality Level | 300 |
grade | certified reference material, pharmaceutical secondary standard |
form | neat |
CofA | current certificate can be downloaded |
application(s) | HPLC: suitable, gas chromatography (GC): suitable |
Featured Industry | Pharmaceutical (small molecule) |
format | neat |
pharmacopeia traceability | traceable to PhEur Y0001121, traceable to USP 1011709 |
SMILES string | COc1ccc(cc1C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)-c5ccc6cc(ccc6c5)C(O)=O |
InChI | 1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)/t17-,18+,19-,28- |
InChI key | LZCDAPDGXCYOEH-AADAIPAGSA-N |
pictograms | GHS08 |
signalword | Warning |
hcodes | H361d |
pcodes | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point F | Not applicable |
Flash Point C | Not applicable |