Diethylene glycol
Empirical Formula (Hill Notation): | C4H10O3 |
Linear Formula: | (HOCH2CH2)2O |
CAS Number: | 111-46-6 |
Molecular Weight: | 106.12 |
Beilstein/REAXYS Number: | 969209 |
EC Number: | 203-872-2 |
MDL number: | MFCD00002882 |
PubChem Substance ID: | 329823075 |
NACRES: | NA.24 |
Кат. номер |
PHR1045-1G |
PHR1045-1G-PW |
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Diethylene glycol is a a four carbon dimer of ethylene glycol and finds applications as antifreeze, solvent, humectant, hydraulic fluid and brake fluid. It is a potential neuro- and nephrotoxin for humans. It may also be utilized in moisturizers, lubricants, emulsification agents, additives and solvents.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Diethylene glycol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC).
Diethylene glycol may be used as a standard in the determination of diethylene glycol present in serum samples using gas chromatography (GC). It may also be used as a reference standard in validating the composition of diethylene glycol in propolis syrup consumed by intoxicated victims using nuclear magnetic resonance studies (NMR) and gas chromatography coupled with flame ionization detector (GC-FID).
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
This Certified Reference Material (CRM) is produced and certified in accordance with
ISO 17034 and
ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0277 in the slot below. This is an example certificate only and may not be the lot that you receive.
Quality Level | 300 |
grade | certified reference material, pharmaceutical secondary standard |
vapor density | 2.14 (vs air) |
vapor pressure | 0.01 mmHg ( 20 °C) |
CofA | current certificate can be downloaded |
autoignition temp. | 442 °F |
expl. lim. | 2-12.3 % |
application(s) | HPLC: suitable, gas chromatography (GC): suitable |
refractive index | n20/D 1.447 (lit.) |
bp | 245 °C (lit.) |
mp | 10 °C (lit.) |
density | 1.118 g/mL at 25 °C (lit.) |
Featured Industry | Cleaning Products Cosmetics Food and Beverages Personal Care Pharmaceutical (small molecule) |
format | neat |
pharmacopeia traceability | traceable to PhEur Y0000217, traceable to USP 1193265 |
SMILES string | OCCOCCO |
InChI | 1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2 |
InChI key | MTHSVFCYNBDYFN-UHFFFAOYSA-N |
pictograms | GHS07 |
signalword | Warning |
hcodes | H302 |
pcodes | P264 - P270 - P301 + P312 - P501 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 1 |
Flash Point F | 280.4 °F - closed cup |
Flash Point C | 138 °C - closed cup |