Protein Degrader Building Blocks
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Pomalidomide-C6-PEG1-C3-PEG1-butyl amine hydrochloride 913987-50MG
Empirical Formula (Hill Notation): C30H44N4O7 · xHCl Molecular Weight: 572.69 (free base basis) ApplicationProtein degrader building block Pomalidomide-C6-PEG1-C3-PEG1-butyl amine hydrochloride enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with an acid on the target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 95% form powder storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCCCCOCCCCCOCCCCCCN)=O)=O)NC1=O.Cl, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCCCCOCCCCCOCCCCCCN)=O)=O)NC1=O.Cl
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide 906050-50MG
Empirical Formula (Hill Notation): C30H42IN3O7 CAS Number: 1835705-76-4 Molecular Weight: 683.57 ApplicationProtein degrader builiding block Pomalidomide-C6-PEG1-C3-PEG1-Butyl Iodide enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form powder or crystals storage temp. 2-8°C SMILES string ICCCCCCOCCCCCOCCCCCC(NC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)=O
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-C6-PEG3-butyl amine hydrochloride 905208-50MG
Empirical Formula (Hill Notation): C29H42N4O8 · xHCl Molecular Weight: 574.67 (free base basis) ApplicationProtein degrader builiding block Pomalidomide-C6-PEG3-butyl amine (HCl salt) enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 98% form (Liquid or Semi-Solid or Paste or Solid) storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCCCCOCCOCCOCCCCCCN)=O)=O)NC1=O.Cl, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCCCCOCCOCCOCCCCCCN)=O)=O)NC1=O.Cl
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-C6-PEG3-butyl iodide 904708-50MG
Empirical Formula (Hill Notation): C29H40IN3O8 CAS Number: 1835705-70-8 Molecular Weight: 685.55 ApplicationProtein degrader builiding block Pomalidomide-C6-PEG3-butyl iodide enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form powder or crystals storage temp. 2-8°C SMILES string ICCCCCCOCCOCCOCCCCCC(NC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)=O, ICCCCCCOCCOCCOCCCCCC(NC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)=O
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-C9-CO2H 901525-50MG
Empirical Formula (Hill Notation): C23H29N3O6 CAS Number: 2243000-24-8 Molecular Weight: 443.49 NACRES: NA.22 ApplicationProtein degrader builiding block Pomalidomide-C9-CO2H enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradationn,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 95% form powder or crystals storage temp. 2-8°C SMILES string OC(CCCCCCCCCNC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)=O, OC(CCCCCCCCCNC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG1-CO2H 901527-50MG
Empirical Formula (Hill Notation): C18H19N3O7 CAS Number: 2139348-60-8 Molecular Weight: 389.36 NACRES: NA.22 ApplicationProtein degrader builiding block Pomalidomide-PEG1-CO2H enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 95% form powder or crystals storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCC(O)=O)=O)NC1=O, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCC(O)=O)=O)NC1=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG1-NH2 hydrochloride 901516-50MG
Empirical Formula (Hill Notation): C17H18N4O6 · xHCl Molecular Weight: 374.35 (free base basis) ApplicationProtein degrader builiding block Pomalidomide-C9-CO2H enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 95% form powder or crystals shipped in wet ice storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCN)=O)=O)NC1=O.Cl, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCN)=O)=O)NC1=O.Cl
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG2-butyl amine hydrochloride 911003-50MG
Empirical Formula (Hill Notation): C23H30N4O7 Molecular Weight: 474.51 ApplicationProtein degrader builiding block Pomalidomide-PEG2-butyl amine hydrochloride enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant amine acid for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form solid storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCCCCCN)=O)=O)NC1=O.Cl, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCCCCCN)=O)=O)NC1=O.Cl
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG2-butyl CO2H 910449-50MG
Empirical Formula (Hill Notation): C24H29N3O9 Molecular Weight: 503.50 ApplicationProtein degrader builiding block Pomalidomide-PEG2-butyl CO2H enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form powder storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCCCCCC(O)=O)=O)=O)NC1=O, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCCCCCC(O)=O)=O)=O)NC1=O
Safety Informationpictograms GHS08 signalword Danger hcodes H360D pcodes P201 - P308 + P313 WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG2-butyl iodide 904724-50MG
Empirical Formula (Hill Notation): C23H28IN3O7 CAS Number: 1835705-72-0 Molecular Weight: 585.39 ApplicationProtein degrader builiding block Pomalidomide-PEG2-butyl Iodide enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeting the C481S Ibrutinib-Resistance Mutation in Brutons Tyrosine Kinase Using PROTAC-Mediated Degradation,
Modular PROTAC Design for the Degradation of Oncogenic BCR-?ABL,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form powder or crystals storage temp. 2-8°C SMILES string ICCCCCCOCCOCC(NC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)=O, ICCCCCCOCCOCC(NC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)=O
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG2-CO2H 901526-50MG
Empirical Formula (Hill Notation): C20H23N3O8 CAS Number: 2140807-17-4 Molecular Weight: 433.41 NACRES: NA.22 ApplicationProtein degrader builiding block Pomalidomide-PEG2-CO2H enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 95% form powder or crystals storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCOCCC(O)=O)=O)NC1=O, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCOCCC(O)=O)=O)NC1=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG2-NH2 hydrochloride 901513-50MG
Empirical Formula (Hill Notation): C19H22N4O7 · xHCl Molecular Weight: 418.40 (free base basis) NACRES: NA.22 ApplicationProtein degrader builiding block Pomalidomide-PEG2-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 95% form powder or crystals shipped in wet ice storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCN)=O)=O)NC1=O.Cl, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCN)=O)=O)NC1=O.Cl
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG3-CO2H 901504-50MG
Empirical Formula (Hill Notation): C22H27N3O9 CAS Number: 2138440-82-9 Molecular Weight: 477.46 NACRES: NA.22 ApplicationProtein degrader builiding block Pomalidomide-PEG3-CO2H enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradatio,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 95% form powder or crystals storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCOCCOCCC(O)=O)=O)NC1=O, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCOCCOCCC(O)=O)=O)NC1=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG3-NH2 hydrochloride 901495-50MG
Empirical Formula (Hill Notation): C21H26N4O8 · xHCl Molecular Weight: 462.45 (free base basis) NACRES: NA.22 ApplicationProtein degrader builiding block Pomalidomide-PEG3-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation ,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 95% form powder or crystals shipped in wet ice storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCN)=O)=O)NC1=O.Cl, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCN)=O)=O)NC1=O.Cl
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG4-CO2H 901824-50MG
Empirical Formula (Hill Notation): C24H31N3O10 CAS Number: 2138440-81-8 Molecular Weight: 521.52 ApplicationProtein degrader builiding block Pomalidomide-PEG4-CO2H enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,.This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,
Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыstorage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCOCCOCCOCCC(O)=O)=O)NC1=O, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCOCCOCCOCCC(O)=O)=O)NC1=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG4-NH2 hydrochloride 901830-50MG
Empirical Formula (Hill Notation): C23H31ClN4O9 Molecular Weight: 542.97 ApplicationProtein degrader builiding block Pomalidomide-PEG4-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form powder or crystals mp 98-109 °C storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCN)=O)=O)NC1=O.Cl
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG5-CO2H 901828-50MG
Empirical Formula (Hill Notation): C26H35N3O11 CAS Number: 2139348-63-1 Molecular Weight: 565.57 NACRES: NA.22 ApplicationProtein degrader builiding block Pomalidomide-PEG5-CO2H enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCOCCOCCOCCOCCC(O)=O)=O)NC1=O, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCOCCOCCOCCOCCC(O)=O)=O)NC1=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG5-NH2 hydrochloride 901831-50MG
Empirical Formula (Hill Notation): C25H35ClN4O10 Molecular Weight: 587.02 NACRES: NA.22 General descriptionProtein degrader builiding block Pomalidomide-PEG5-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыform powder storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCOCCN)=O)=O)NC1=O.Cl, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCOCCN)=O)=O)NC1=O.Cl
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG6-butyl amine hydrochloride 905224-50MG
Empirical Formula (Hill Notation): C31H46N4O11 · xHCl Molecular Weight: 650.72 (free base basis) ApplicationPartial PROTAC Pomalidomide-PEG6-butyl amine (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other Partial PROTACs with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Protein degrader builiding block Pomalidomide-PEG6-Butyl Amine (HCl salt) enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form powder or crystals storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCOCCOCCCCCCN)=O)=O)NC1=O.Cl, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCOCCOCCCCCCN)=O)=O)NC1=O.Cl
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG6-butyl CO2H 910481-50MG
Empirical Formula (Hill Notation): C32H45N3O13 Molecular Weight: 679.71 ApplicationProtein degrader builiding block Pomalidomide-PEG6-Butyl CO2H enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form chunks storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCOCCOCCCCCCC(O)=O)=O)=O)NC1=O, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCOCCOCCCCCCC(O)=O)=O)=O)NC1=O
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG6-butyl iodide 903442-50MG
Empirical Formula (Hill Notation): C31H44IN3O11 CAS Number: 1835705-74-2 Molecular Weight: 761.60 ApplicationProtein degrader builiding block Pomalidomide-PEG6-butyl iodide enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form powder or crystals storage temp. 2-8°C SMILES string ICCCCCCOCCOCCOCCOCCOCCOCC(NC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)=O, ICCCCCCOCCOCCOCCOCCOCCOCC(NC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)=O
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG6-CO2H 901829-50MG
Empirical Formula (Hill Notation): C28H39N3O12 CAS Number: 2225148-49-0 Molecular Weight: 609.62 NACRES: NA.22 ApplicationProtein degrader builiding block Pomalidomide-PEG6-CO2H enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradations,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form liquid storage temp. 2-8°C SMILES string O=C(NC1=O)CCC1N(C2=O)C(C3=C2C=CC=C3NCCOCCOCCOCCOCCOCCOCCC(O)=O)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-PEG6-NH2 hydrochloride 901832-50MG
Empirical Formula (Hill Notation): C27H39ClN4O11 Molecular Weight: 631.07 NACRES: NA.22 ApplicationProtein degrader builiding block Pomalidomide-PEG6-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 98% form powder storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCOCCOCCN)=O)=O)NC1=O.Cl, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCOCCOCCN)=O)=O)NC1=O.Cl
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Potassium benzyl cyanocarbamate
Empirical Formula (Hill Notation): C9H7KN2O2 CAS Number: 50909-46-1 Molecular Weight: 214.26 PubChem Substance ID: 329764979 NACRES: NA.22
Кат. номер 745413-5G 745413-1G ApplicationIn tandem with TMSCl, product generates an in situ N-silylcarbodiimide that rapidly guanylates a variety of amines at room temperature.
Packaging
1, 5 g in glass bottleПараметрыassay 97% Quality Level 100, mp 228-232 °C SMILES string [K]N(C#N)C(=O)OCc1ccccc1 InChI 1S/C9H8N2O2.K/c10-7-11-9(12)13-6-8-4-2-1-3-5-8;/h1-5H,6H2,(H,11,12);/q;+1/p-1 InChI key HZBHQPNPJVDRMR-UHFFFAOYSA-M
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Propargyl 1H-imidazole-1-carboxylate
Empirical Formula (Hill Notation): C7H6N2O2 CAS Number: 83395-38-4 Molecular Weight: 150.13 MDL number: MFCD18830798 PubChem Substance ID: 329765934 NACRES: NA.22
Кат. номер 748781-25G 748781-1G 748781-5G ПараметрыQuality Level 200, assay 95% mp 45-50 °C shipped in wet ice storage temp. 2-8°C SMILES string O=C(OCC#C)n1ccnc1 InChI 1S/C7H6N2O2/c1-2-5-11-7(10)9-4-3-8-6-9/h1,3-4,6H,5H2 InChI key LLVCOZOEWQQTAV-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Propargyl-PEG1-acid 901567-50MG
Empirical Formula (Hill Notation): C6H8O3 CAS Number: 55683-37-9 Molecular Weight: 128.13 MDL number: MFCD10689189 ApplicationThis is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains a single PEG unit to help improve solubility.
Propargyl-PEG1-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG1-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation,.Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form liquid storage temp. 20°C SMILES string OC(CCOCC#C)=O, OC(CCOCC#C)=O InChI 1S/C6H8O3/c1-2-4-9-5-3-6(7)8/h1H,3-5H2,(H,7,8) InChI key GMFDYXLFHSFUHE-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Узнать цену -
Propargyl-PEG3-acid 901565-50MG
Empirical Formula (Hill Notation): C10H16O5 CAS Number: 1347760-82-0 Molecular Weight: 216.23 MDL number: MFCD22201521 NACRES: NA.22 ApplicationPropargyl-PEG3-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG3-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation,.
This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains three PEG units to help improve solubility.Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыform liquid storage temp. 20°C SMILES string C#CCOCCOCCOCCC(O)=O, C#CCOCCOCCOCCC(O)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Узнать цену -
Reacta-Sil™
MDL number: MFCD00080961 PubChem Substance ID: 329755872 NACRES: NA.22
PackagingКат. номер 394629-25ML 394629-1ML 394629-10X1ML 394629-10ML
25 mL in ampuleOther NotesSediment is common and does not affect useLegal InformationReacta-Sil is a trademark of Sigma-Aldrich Co. LLCПараметрыQuality Level 100, density 0.938 g/mL at 25 °C (lit.) SMILES string C[Si](C)(C)Cl.c1ccncc1.C[Si](C)(C)N[Si](C)(C)C InChI 1S/C6H19NSi2.C5H5N.C3H9ClSi/c1-8(2,3)7-9(4,5)6;1-2-4-6-5-3-1;1-5(2,3)4/h7H,1-6H3;1-5H;1-3H3 InChI key MNIBVWDUHGUQIQ-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS05,GHS06 signalword Danger hcodes H225 - H302 + H332 - H311 - H314 pcodes P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 3286 8(6.1)(3) / PGII WGK Germany WGK 2 Flash Point F 50.0 °F - closed cup Flash Point C 10 °C - closed cup Узнать цену -
Silicon tetrachloride 688509-25ML
Empirical Formula (Hill Notation): Cl4Si Linear Formula: SiCl4 CAS Number: 10026-04-7 Molecular Weight: 169.90 MDL number: MFCD00011229 PubChem Substance ID: 329761169 NACRES: NA.23 General descriptionAtomic number of base material: 14 SiliconApplicationPrecursors Packaged for Depositions Systems
Packaging
25 mL in stainless steel cylinderПараметрыQuality Level 100, vapor density 5.86 (vs air) vapor pressure 420 mmHg ( 37.7 °C) assay 99.998% trace metals basis form liquid reaction suitability core: silicon bp 57.6 °C (lit.) mp −70 °C (lit.) density 1.483 g/mL at 25 °C (lit.) SMILES string Cl[Si](Cl)(Cl)Cl InChI 1S/Cl4Si/c1-5(2,3)4 InChI key FDNAPBUWERUEDA-UHFFFAOYSA-N
Safety Informationpictograms GHS05,GHS06 signalword Danger hcodes H301 + H331 - H314 - H335 pcodes P261 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 Target Organs Respiratory system Supp Hazards EUH014 - EUH071 Personal Protective Equipment Faceshields,, Gloves,, Goggles, RIDADR UN 1818 8 / PGII WGK Germany WGK 1 Узнать цену -
t-Boc-N-amido-PEG2-CH2CO2H 901577-50MG
Empirical Formula (Hill Notation): C11H21NO6 CAS Number: 108466-89-3 Molecular Weight: 263.29 MDL number: MFCD17019374 Applicationt-Boc-N-amido-PEG2-CH2CO2H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG2-CH2CO2H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation,.
This is a crosslinker with a t-Boc protected amine on one end and a carboxyl group on the other end. The compound contains two PEG units to help improve solubility.Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form liquid density 1.15 g/cm3 (lit.) storage temp. 20°C SMILES string OC(COCCOCCNC(OC(C)(C)C)=O)=O, OC(COCCOCCNC(OC(C)(C)C)=O)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Узнать цену -
t-Boc-N-amido-PEG3-CH2CO2H 901575-50MG
Empirical Formula (Hill Notation): C13H25NO7 CAS Number: 462100-06-7 Molecular Weight: 307.34 MDL number: MFCD22376773 NACRES: NA.22 Applicationt-Boc-N-amido-PEG3-CH2CO2H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG3-CH2CO2H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation,.
This is a crosslinker with a t-Boc protected amine on one end and a carboxyl group on the other end. The compound contains three PEG units to help improve solubility.Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form liquid storage temp. 20°C SMILES string OC(COCCOCCOCCNC(OC(C)(C)C)=O)=O, OC(COCCOCCOCCNC(OC(C)(C)C)=O)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Узнать цену -
TBAF(9-Ph-9-fluorenol)3 900016-1G
Empirical Formula (Hill Notation): C73H78FNO3 Molecular Weight: 1036.40 PubChem Substance ID: 329769761 NACRES: NA.22 General descriptionTBAF(9-Ph-9-fluorenol)3 is a fluoride–alcohol complex. It is formed by reacting 9-phenylfluoren-9-ol with tetrabutylammonium fluoride trihydrate (TBAF(H2O)3). The geometric structure and bonding of TBAF(9-Ph-9-fluorenol)3 have been investigated.ApplicationNucleophilic fluorinating reagent is a more convenient crystalline solid for handling and storage compared to tetrabutylammonium fluoride hydrate (Aldrich 241512). As reported by Engle and Gouverneur, these solids display comparable reactivity on similar substrates.
Packaging
1 g in glass bottleLegal InformationCoordination diversity in hydrogen-bonded homoleptic fluoride–alcohol complexes modulates reactivity,Параметрыform powder Quality Level 100, mp 138-143 °C SMILES string CCCC[N+](CCCC)(CCCC)CCCC.OC1(C2=CC=CC=C2)C3=C(C=CC=C3)C4=C1C=CC=C4.OC5(C6=CC=CC=C6)C7=C(C=CC=C7)C8=C5C=CC=C8.OC9(C%10=CC=CC=C%10)C%11=C(C=CC=C%11)C%12=C9C=CC=C%12.[F-] InChI 1S/3C19H14O.C16H36N.FH/c3*20-19(14-8-2-1-3-9-14)17-12-6-4-10-15(17)16-11-5-7-13-18(16)19;1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;/h3*1-13,20H;5-16H2,1-4H3;1H/q;;;+1;/p-1 InChI key HTKORNSKGASQCX-UHFFFAOYSA-M
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
TBAF(pin)2 900021-1G
Empirical Formula (Hill Notation): C28H64FNO4 CAS Number: 1823217-44-2 Molecular Weight: 497.81 PubChem Substance ID: 329769764 General descriptionTBAF(pin)2 is a fluoride–alcohol complex with coordination number four. It can be obtained by reacting pinacol (pin) with tetrabutylammonium fluoride trihydrate (TBAF(H2O)3). The geometric structure and bonding of TBAF(pin)2 have been studied.ApplicationNucleophilic fluorinating reagent is a more convenient crystalline solid for handling and storage compared to tetrabutylammonium fluoride hydrate (Aldrich 241512). As reported by Engle and Gouverneur, these solids display comparable reactivity on similar substrates.
Packaging
1 g in glass bottleOther NotesCoordination diversity in hydrogen-bonded homoleptic fluoride–alcohol complexes modulates reactivity,Параметрыform powder Quality Level 100, mp 162-167 °C (d) SMILES string OC(C)(C)C(C)(C)O.OC(C)(C)C(C)(C)O.CCCC[N+](CCCC)(CCCC)CCCC.[F-] InChI 1S/C16H36N.2C6H14O2.FH/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;2*1-5(2,7)6(3,4)8;/h5-16H2,1-4H3;2*7-8H,1-4H3;1H/q+1;;;/p-1 InChI key CVEUWEZBMVLEKR-UHFFFAOYSA-M
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
TBAF(pTol3COH)2 809578-1G
Empirical Formula (Hill Notation): C60H80FNO2 Molecular Weight: 866.28 PubChem Substance ID: 329769169 NACRES: NA.22 ApplicationNucleophilic fluorinating reagent is a more convenient crystalline solid for handling and storage compared to tetrabutylammonium fluoride hydrate (Aldrich 241512). As reported by Engle and Gouverneur, these solids display comparable reactivity on similar substrates.
Packaging
1 g in glass bottleOther NotesCoordination diversity in hydrogen-bonded homoleptic fluoride–alcohol complexes modulates reactivity,Параметрыform powder Quality Level 100, mp 136-141 °C SMILES string OC(C1=CC=C(C)C=C1)(C2=CC=C(C)C=C2)C3=CC=C(C)C=C3.OC(C4=CC=C(C)C=C4)(C5=CC=C(C)C=C5)C6=CC=C(C)C=C6.CCCC[N+](CCCC)(CCCC)CCCC.[F-] InChI 1S/2C22H22O.C16H36N.FH/c2*1-16-4-10-19(11-5-16)22(23,20-12-6-17(2)7-13-20)21-14-8-18(3)9-15-21;1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;/h2*4-15,23H,1-3H3;5-16H2,1-4H3;1H/q;;+1;/p-1 InChI key BWOIZLRULLMREE-UHFFFAOYSA-M
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
tert-Butyl carbazate
Empirical Formula (Hill Notation): C5H12N2O2 Linear Formula: (CH3)3COCONHNH2 CAS Number: 870-46-2 Molecular Weight: 132.16 Beilstein/REAXYS Number: 1756967 EC Number: 212-795-3 MDL number: MFCD00007593 PubChem Substance ID: 24892122 NACRES: NA.22
Кат. номер B91005-100G B91005-25G B91005-5G B91005-500G B91005-25KG ApplicationEmployed in a palladium-catalyzed cross-coupling with vinyl halides leading to N-Boc-N-alkenylhydrazines.
Reagent used in solid phase peptide synthesis and in -amino aldehyde optical purity determinations. Condenses with aldehydes to form hydrazones which are intermediates in the synthesis of HIV-1 protease inhibitors.
Packaging
5, 25, 100, 500 g in poly bottleПараметрыQuality Level 200, assay 98% application(s) peptide synthesis: suitable bp 63-65 °C/0.1 mmHg (lit.) mp 39-42 °C (lit.) SMILES string O=C(NN)OC(C)(C)C InChI 1S/C5H12N2O2/c1-5(2,3)9-4(8)7-6/h6H2,1-3H3,(H,7,8) InChI key DKACXUFSLUYRFU-UHFFFAOYSA-N
Safety Informationpictograms GHS02 signalword Danger hcodes H228 pcodes P210 Personal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F 195.8 °F Flash Point C 91 °C Узнать цену -
tert-Butyl carbazate solution
Linear Formula: C5H12N2O2 CAS Number: 870-46-2 MDL number: MFCD00007593
Кат. номер 901606-100ML 901606-25ML ApplicationEmployed in a palladium-catalyzed cross-coupling with vinyl halides leading to N-Boc-N-alkenylhydrazines.
Reagent used in solid phase peptide synthesis and in -amino aldehyde optical purity determinations. Condenses with aldehydes to form hydrazones which are intermediates in the synthesis of HIV-1 protease inhibitors.Параметрыform liquid concentration 1.0 M in dichloromethane refractive index n/D 1.427 density 1.290 g/mL InChI 1S/C5H12N2O2/c1-5(2,3)9-4(8)7-6/h6H2,1-3H3,(H,7,8) InChI key DKACXUFSLUYRFU-UHFFFAOYSA-N
Safety Informationpictograms GHS07,GHS08 signalword Warning hcodes H315 - H319 - H336 - H351 pcodes P201 - P302 + P352 - P305 + P351 + P338 - P308 + P313 Target Organs Central nervous system RIDADR UN 1593 6.1 / PGIII WGK Germany WGK 3 Узнать цену -
tert-Butylchlorodimethylsilane solution
Empirical Formula (Hill Notation): C6H15ClSi Linear Formula: (CH3)3CSi(CH3)2Cl CAS Number: 18162-48-6 Molecular Weight: 150.72 Beilstein/REAXYS Number: 505999 MDL number: MFCD00000501 PubChem Substance ID: 24870907 NACRES: NA.22
Кат. номер 473464-100G 473464-50G ПараметрыQuality Level 200, concentration 50 wt. % in toluene refractive index n20/D 1.46 bp 113 °C density 0.87 g/mL at 20 °C (lit.), 0.866 g/mL at 25 °C SMILES string CC(C)(C)[Si](C)(C)Cl InChI 1S/C6H15ClSi/c1-6(2,3)8(4,5)7/h1-5H3 InChI key BCNZYOJHNLTNEZ-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS05,GHS07,GHS08,GHS09 signalword Danger hcodes H225 - H304 - H314 - H336 - H361d - H373 - H411 pcodes P210 - P280 - P301 + P310 + P331 - P301 + P330 + P331 - P303 + P361 + P353 - P305 + P351 + P338 + P310 Target Organs Central nervous system Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 2924 8(3) / PGII WGK Germany WGK 2 Flash Point F 44.6 °F - closed cup Flash Point C 7 °C - closed cup Узнать цену -
tert-Butylchlorodiphenylsilane solution
Empirical Formula (Hill Notation): C16H19ClSi CAS Number: 58479-61-1 Molecular Weight: 274.86 MDL number: MFCD00000497 PubChem Substance ID: 329762399 NACRES: NA.22
Кат. номер 702730-100ML 702730-500ML 702730-1G 702730-250MG Applicationtert-Butylchlorodiphenylsilane can be used to prepare 1-benzyloxy-3-(tert-butyldiphenylsilyloxy)propan-2-ol, a key intermediate for the synthesis of mono-O-protected pyrimidine acyclic nucleosides.
Packaging
100, 500 mL in Sure/Seal™ПараметрыQuality Level 100, concentration 1 M in methylene chloride bp 40 °C density 1.249 g/mL at 25 °C SMILES string CC(C)(C)[Si](Cl)(c1ccccc1)c2ccccc2 InChI 1S/C16H19ClSi/c1-16(2,3)18(17,14-10-6-4-7-11-14)15-12-8-5-9-13-15/h4-13H,1-3H3 InChI key MHYGQXWCZAYSLJ-UHFFFAOYSA-N
Safety Informationpictograms GHS05,GHS07,GHS08 signalword Danger hcodes H314 - H335 - H336 - H351 pcodes P201 - P202 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 Personal Protective Equipment Faceshields,, Gloves,, Goggles, RIDADR UN 2922 6.1(8) / PGII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
tert-Butyldimethylsilyl chloride
Empirical Formula (Hill Notation): C6H15ClSi Linear Formula: (CH3)3CSi(CH3)2Cl CAS Number: 18162-48-6 Molecular Weight: 150.72 Beilstein/REAXYS Number: 505999 EC Number: 242-042-4 MDL number: MFCD00000501 PubChem Substance ID: 24851442 NACRES: NA.22
Кат. номер 190500-25KG 190500-100G 190500-1KG 190500-25G 190500-500G 190500-5G 190500-10KG Applicationtert-Butyldimethylsilyl chloride (TBDMSCl) is an organosilicon compound that can be used as a versatile protecting reagent for alcohols, amines, amides, and various carboxylic acids. It is also used in the preparation of isoxazoline N-oxides from -bromonitroalkanes and olefins. TBDMSCl is used as a precursor that forms a silicon substrate for Ag/ZnO/graphene-based nanocomposites to form effective photocatalytic system for hydrogen production.Packaging5, 25, 100, 500 g in glass bottle
1 kg in glass bottleПараметрыQuality Level 200 grade reagent grade assay 97% bp 125 °C (lit.) mp 86-89 °C (lit.) SMILES string CC(C)(C)[Si](C)(C)Cl InChI 1S/C6H15ClSi/c1-6(2,3)8(4,5)7/h1-5H3 InChI key BCNZYOJHNLTNEZ-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS05,GHS09 signalword Danger hcodes H228 - H314 - H411 pcodes P210 - P260 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338 + P310 RIDADR UN 2925 8(4.1) / PGII WGK Germany WGK 2 Flash Point F 71.6 °F Flash Point C 22 °C Узнать цену -
tert-Butyldimethylsilyl chloride solution 372951-100ML
Empirical Formula (Hill Notation): C6H15ClSi Linear Formula: (CH3)3CSi(CH3)2Cl CAS Number: 18162-48-6 Molecular Weight: 150.72 Beilstein/REAXYS Number: 505999 MDL number: MFCD00000501 PubChem Substance ID: 24863185 NACRES: NA.22 ПараметрыQuality Level 100, concentration 1.0 M in THF density 0.87 g/mL at 20 °C (lit.), 0.879 g/mL at 25 °C SMILES string CC(C)(C)[Si](C)(C)Cl InChI 1S/C6H15ClSi/c1-6(2,3)8(4,5)7/h1-5H3 InChI key BCNZYOJHNLTNEZ-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS05,GHS07,GHS08 signalword Danger hcodes H225 - H302 - H314 - H335 - H336 - H351 - H412 pcodes P210 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 Supp Hazards EUH019 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 2924 8(3) / PGII WGK Germany WGK 2 Flash Point F 1.4 °F - closed cup Flash Point C -17 °C - closed cup Узнать цену -
tert-Butyldimethylsilyl chloride solution 384429-100ML
Empirical Formula (Hill Notation): C6H15ClSi Linear Formula: (CH3)3CSi(CH3)2Cl CAS Number: 18162-48-6 Molecular Weight: 150.72 Beilstein/REAXYS Number: 505999 MDL number: MFCD00000501 PubChem Substance ID: 24863996 NACRES: NA.22 ПараметрыQuality Level 100, concentration 1.0 M in methylene chloride density 0.87 g/mL at 20 °C (lit.), 1.225 g/mL at 25 °C SMILES string CC(C)(C)[Si](C)(C)Cl InChI 1S/C6H15ClSi/c1-6(2,3)8(4,5)7/h1-5H3 InChI key BCNZYOJHNLTNEZ-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS05,GHS07,GHS08,GHS09 signalword Danger hcodes H226 - H314 - H336 - H351 - H411 pcodes P210 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 Target Organs Central nervous system Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 2920 3(8) / PGII WGK Germany WGK 2 Flash Point F 136.4 °F - closed cup Flash Point C 58 °C - closed cup Узнать цену -
tert-Butyldimethylsilyl trifluoromethanesulfonate
Empirical Formula (Hill Notation): C7H15F3O3SSi Linear Formula: CF3SO3Si(CH3)2C(CH3)3 CAS Number: 69739-34-0 Molecular Weight: 264.34 Beilstein/REAXYS Number: 2370068 EC Number: 274-102-0 MDL number: MFCD00000405 PubChem Substance ID: 24853546 NACRES: NA.22
PackagingКат. номер 226149-1G 226149-25G 226149-5G
1, 5, 25 g in glass bottleApplicationThis reagent was used to introduce a bulky tert-butyl dimethylsilyl group onto a cis-bis(alkenyl)oxirane facilitating a room temperature Cope rearrangement to a 2-CF3-4,5-dihydrooxepin.
Together with a thiolane promotes a rapid and efficient chalcogenide-Morita-Baylis-Hillman reaction.Параметрыgrade reagent grade Quality Level 200, assay 98% refractive index n20/D 1.385 (lit.) bp 65-67 °C/12 mmHg (lit.) density 1.151 g/mL at 25 °C (lit.) storage temp. 2-8°C SMILES string CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F InChI 1S/C7H15F3O3SSi/c1-6(2,3)15(4,5)13-14(11,12)7(8,9)10/h1-5H3 InChI key WLLIXJBWWFGEHT-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS05,GHS07 signalword Danger hcodes H226 - H314 - H335 pcodes P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 2920 3(8) / PGII WGK Germany WGK 3 Flash Point F 98.6 °F - closed cup Flash Point C 37 °C - closed cup Узнать цену -
Tetrabutylammonium fluoride solution
Empirical Formula (Hill Notation): C16H36FN Linear Formula: [CH3(CH2)3]4NF CAS Number: 429-41-4 Molecular Weight: 261.46 Beilstein/REAXYS Number: 3762762 MDL number: MFCD00011747 PubChem Substance ID: 24852802 NACRES: NA.22
Кат. номер 216143-4X100ML 216143-2.5L 216143-500ML 216143-1L 216143-5ML 216143-50ML 216143-100ML 216143-2L 216143-20L ApplicationTetrabutylammonium fluoride (TBAF) can be used as a reagent:- For the deprotection of silyl and N-sulfonyl groups.
- In the fluorination reactions.
- To synthesize 2-substituted indoles by cyclization reaction of various 2-ethynylanilines with terminal alkynes using Pd catalyst. It can also be used as an activator in the synthesis of arylated or alkenylated alkynes by the coupling reaction of aryl and alkenyl halides with terminal alkynes in the presence of Pd catalyst.
Reactant for preparation of:- Triple monoamine reuptake inhibitors as a new generation of antidepressants
- Alcohols via hydrolysis of alkyl silyl ethers neutral pH in mixed organic-aqueous buffered solutions
- Oligoribonucleotides with phosphonate-modified linkages
- Aryl alkyl alcohols via Nozaki-Hiyama allylation catalyzed by chiral bipyridyldiol ligands and chromium trichloride
- Conjugated dienoic acid esters using Suzuki coupling reactions
- Macrocyclic o-aminobenzamide Hsp90 inhibitorwith antitumor activity
- Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors
- Anti-diabetic polyacetylenic glucosides
Packaging5 mL in glass bottle
1 L in Sure/Seal™
50, 100, 4×100, 500 mL in Sure/Seal™
2.5 L in glass bottleПараметрыQuality Level 200 concentration 1.0 M in THF impurities ~5 wt. % water density 0.903 g/mL at 25 °C storage temp. 2-8°C SMILES string [F-].CCCC[N+](CCCC)(CCCC)CCCC InChI 1S/C16H36N.FH/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;/h5-16H2,1-4H3;1H/q+1;/p-1 InChI key FPGGTKZVZWFYPV-UHFFFAOYSA-M
Safety Informationpictograms GHS02,GHS07,GHS08,GHS09 signalword Danger hcodes H225 - H302 - H315 - H319 - H335 - H336 - H351 - H411 pcodes P210 - P273 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338 - P308 + P313 Supp Hazards EUH019 - EUH032 RIDADR UN 2924 8(3) / PGII WGK Germany WGK 3 Flash Point F 1.4 °F - closed cup Flash Point C -17 °C - closed cup Узнать цену -
Tetrabutylammonium fluoride trihydrate
Empirical Formula (Hill Notation): C16H36FN · 3H2O Linear Formula: [CH3(CH2)3]4NF · 3H2O CAS Number: 87749-50-6 Molecular Weight: 315.51 Beilstein/REAXYS Number: 3761900 EC Number: 207-057-2 MDL number: MFCD00149981 PubChem Substance ID: 57653206 NACRES: NA.22
Кат. номер 86872-INTR 86872-10G 86872-250G 86872-50G General descriptionTetrabutylammonium fluoride trihydrate is a mild base used in reactions like aldol-type condensation reactions, Michael-type reactions, ring-opening reactions. Its is also used as a promoter in cross-coupling reactions and cyclization of carbocycles and heterocycles.ApplicationReactant for:
Preparation of deprotecting agents in preparation of cellulose derivatives
Synthesis of lipophilic peptides for DNA transfections in vivo
Dehydrobromination reactions
Tetrabutylammonium fluoride trihydrate can be used as a base:- For the dehydrobromination of vinyl bromides to terminal acetylenes.
- In the conversion of 1,1-dibromo-1-alkenes to terminal alkynes via Corey–Fuchs reaction.
- In Hiyama cross-coupling reaction of aryl and heteroaryl chlorides with aryltrialkoxysilanes in the presence of a palladium catalyst.
It can be used to catalyze ethynylation of quinolines and isoquinolines using calcium carbide in aqueous N,N-dimethylacetamide.
Packaging
10, 50, 250 g in poly bottleOther NotesReagent for the cleavage of silyl ethers and other silyl protecting groups; Catalyst for various reactions with silicon compounds; Use as a base in organic synthesis; Instability of anhydrous TBAFПараметрыQuality Level 200, assay ≥97.0% (NT) mp 62-63 °C (lit.) SMILES string O.O.O.[F-].CCCC[N+](CCCC)(CCCC)CCCC InChI 1S/C16H36N.FH.3H2O/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;;;;/h5-16H2,1-4H3;1H;3*1H2/q+1;;;;/p-1 InChI key VEPTXBCIDSFGBF-UHFFFAOYSA-M
Safety Informationpictograms GHS07,GHS09 signalword Warning hcodes H302 - H315 - H319 - H411 pcodes P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 Personal Protective Equipment Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges, RIDADR UN 1759 8 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Tetraethylammonium fluoride hydrate
Empirical Formula (Hill Notation): C8H20FN · xH2O Linear Formula: (C2H5)4NF·xH2O CAS Number: 98330-04-2 Molecular Weight: 149.25 (anhydrous basis) MDL number: MFCD00149990 PubChem Substance ID: 24854124 NACRES: NA.22
Кат. номер 235911-5G 235911-25G ПараметрыQuality Level 100, assay 98% SMILES string O.[F-].CC[N+](CC)(CC)CC InChI 1S/C8H20N.FH.H2O/c1-5-9(6-2,7-3)8-4;;/h5-8H2,1-4H3;1H;1H2/q+1;;/p-1 InChI key YEKUWOWHPVKTCQ-UHFFFAOYSA-M
Safety Informationpictograms GHS07 signalword Warning hcodes H302 + H312 + H332 - H315 - H319 - H335 pcodes P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Tetramethylammonium fluoride
Empirical Formula (Hill Notation): C4H12FN Linear Formula: (CH3)4NF CAS Number: 373-68-2 Molecular Weight: 93.14 EC Number: 206-769-0 MDL number: MFCD00011627 PubChem Substance ID: 24869514 NACRES: NA.22
Кат. номер 459135-5G 459135-1G ApplicationReactant for:- Halide-induced ring opening of 2-substituted aziridinium salts
- Synthesis of fluoro aromatics via fluorodenitration reactions
- Synthesis of sevoflurane in ionic liquids by halogen-exchange fluorination
- Synthesis of fluorinated Poly(oxomolybdates)
Tetramethylammonium fluoride may be used in combination with sulfuryl fluoride for the conversion of aryl phenols to aryl fluorides. It can react with aminosilanes to generate onium amide bases in situ, which can deprotonate heteroarenes.
Useful for halogen exchange.
Packaging
1, 5 g in glass bottleПараметрыQuality Level 100, assay 97% mp 170 °C (dec.) (lit.) SMILES string [F-].C[N+](C)(C)C InChI 1S/C4H12N.FH/c1-5(2,3)4;/h1-4H3;1H/q+1;/p-1 InChI key GTDKXDWWMOMSFL-UHFFFAOYSA-M
Safety Informationpictograms GHS07 signalword Warning hcodes H302 + H312 + H332 - H315 - H319 - H335 pcodes P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Узнать цену -
Tetramethylammonium fluoride tetrahydrate
Empirical Formula (Hill Notation): C4H12FN · 4H2O Linear Formula: (CH3)4N(F) · 4H2O CAS Number: 17787-40-5 Molecular Weight: 165.20 Beilstein/REAXYS Number: 3916184 MDL number: MFCD00149968 PubChem Substance ID: 24846756 NACRES: NA.22
Кат. номер 107212-5G 107212-25G ApplicationReactant for:- Homocoupling of aryl halides via a palladium catalyzed mechanism
- Cross-coupling reactions with alkenylsilanols
- Fluorination of dichloronitrobenzene
Used as:- Reversible absorbing agent for large quantities of hydrogen sulfide in the liquid state
Packaging
5 g in glass bottleПараметрыQuality Level 100, assay 98% mp 39-42 °C (lit.) SMILES string O.O.O.O.[F-].C[N+](C)(C)C InChI 1S/C4H12N.FH.4H2O/c1-5(2,3)4;;;;;/h1-4H3;1H;4*1H2/q+1;;;;;/p-1 InChI key HQFTZNVQVRRDLN-UHFFFAOYSA-M
Safety Informationpictograms GHS07 signalword Warning hcodes H315-H319-H335 pcodes P261-P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany 3 Flash Point F 235.4 °F Flash Point C 113 °C Узнать цену -
Trichloro(1H,1H,2H,2H-perfluorooctyl)silane 448931-10G
Empirical Formula (Hill Notation): C8H4Cl3F13Si Linear Formula: CF3(CF2)5CH2CH2SiCl3 CAS Number: 78560-45-9 Molecular Weight: 481.54 Beilstein/REAXYS Number: 6154526 EC Number: 278-947-6 MDL number: MFCD00042363 PubChem Substance ID: 24868443 NACRES: NA.23 General descriptionTrichloro(1H,1H,2H,2H-perfluorooctyl)silane (PFOCTS) is a chlorosilane that forms a self-assembled monolayer (SAM) on a variety of substrates. It is majorly used to modify the surface with superhydrophobic properties. It is a biocompatible polymer with low surface energy. PFOCTS exhibits anti-fouling properties with high wettability which facilitates the release of different composites from the mold.ApplicationPFOCTS is a coupling agent that is used to silanize the substrate for the fabrication of microfluidic devices using soft lithography. It can also be used on silicon base that forms a chemically patterned surface for quantitative analysis of insoluble surfactants in the polymeric matrix. Alumina membranes can be treated with PFOCTS for the formation of surperhydrophobic polyimide (PI) based nanotube arrays.Packaging10 g in glass bottleПараметрыQuality Level 100 assay 97% refractive index n20/D 1.352 (lit.) bp 192 °C (lit.) density 1.3 g/mL at 25 °C (lit.) SMILES string FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CC[Si](Cl)(Cl)Cl InChI 1S/C8H4Cl3F13Si/c9-25(10,11)2-1-3(12,13)4(14,15)5(16,17)6(18,19)7(20,21)8(22,23)24/h1-2H2 InChI key PISDRBMXQBSCIP-UHFFFAOYSA-N
Safety Informationpictograms GHS05 signalword Danger hcodes H314 pcodes P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 Supp Hazards EUH014 Personal Protective Equipment Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter RIDADR UN 2987 8 / PGII WGK Germany WGK 3 Flash Point F 188.6 °F - closed cup Flash Point C 87 °C - closed cup Узнать цену
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Менеджер по работе с клиентами
С 2010 года мы поставляем оборудование с заводов Европы. Берем на себя все — от подбора оборудования до внедрения на предприятии
Все сотрудники имеют высшее образование, закончили ведущие химические вузы страны, такие как РХТУ им Менделеева.
У большинства компаний срок ожидания составляет 10-12 недель.
Оборудование хранится на сухом отапливаемом складе, где поддерживается ровная температура.
Работаем с PonyExpress и Деловыми линиями. Вы также можете выбрать свою транспортную компанию или забрать товар со склада в Москве.
В случае любых неполадок за свой счет выполним ремонт в сервисном центре или на заводе-изготовителе. Или бесплатно заменим прибор на новый.
Производим пуско-наладку оборудования, валидацию, обучение сотрудников. Если нужно, привлекаем инженеров с заводов- изготовителей.
