Protein Degrader Building Blocks
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Dichloro(methyl)propylsilane
Empirical Formula (Hill Notation): C4H10Cl2Si CAS Number: 4518-94-9 Molecular Weight: 157.11 Beilstein/REAXYS Number: 1733841 EC Number: 224-843-0 MDL number: MFCD00013608 PubChem Substance ID: 57652164 NACRES: NA.22
Кат. номер 68940-25ML 68940-100ML ПараметрыQuality Level 100, assay 97.0% (GC) refractive index n20/D 1.420 density 1.046 g/mL at 20 °C (lit.) SMILES string CCC[Si](C)(Cl)Cl InChI 1S/C4H10Cl2Si/c1-3-4-7(2,5)6/h3-4H2,1-2H3 InChI key GNVPGBIHGALKRR-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS05 signalword Danger hcodes H226 - H314 pcodes P280 - P305 + P351 + P338 - P310 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 2986 3(8) / PGII WGK Germany WGK 1 Flash Point F 80.6 °F - closed cup Flash Point C 27 °C - closed cup Узнать цену -
Dichlorodiethylsilane
Empirical Formula (Hill Notation): C4H10Cl2Si Linear Formula: (C2H5)2SiCl2 CAS Number: 1719-53-5 Molecular Weight: 157.11 Beilstein/REAXYS Number: 605313 EC Number: 217-005-0 MDL number: MFCD00000493 PubChem Substance ID: 24856572 NACRES: NA.22
Кат. номер 274208-25G 274208-5G 274208-100G ПараметрыQuality Level 100, assay 97% refractive index n20/D 1.43 (lit.) bp 125-131 °C (lit.) density 1.05 g/mL at 25 °C (lit.) storage temp. 2-8°C SMILES string CC[Si](Cl)(Cl)CC InChI 1S/C4H10Cl2Si/c1-3-7(5,6)4-2/h3-4H2,1-2H3 InChI key BYLOHCRAPOSXLY-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS05,GHS07 signalword Danger hcodes H226 - H302 - H314 - H335 pcodes P210 - P280 - P301 + P312 + P330 - P303 + P361 + P353 - P305 + P351 + P338 + P310 Target Organs Respiratory system Supp Hazards EUH014 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 1767 3(8) / PGII WGK Germany WGK 1 Flash Point F 79.0 °F Flash Point C 26.1 °C Узнать цену -
Dichlorodiisopropylsilane
Empirical Formula (Hill Notation): C6H14Cl2Si CAS Number: 7751-38-4 Molecular Weight: 185.17 Beilstein/REAXYS Number: 1736244 MDL number: MFCD00054895 PubChem Substance ID: 329755681 NACRES: NA.22
PackagingКат. номер 38385-25ML 38385-5ML
5, 25 mL in glass bottleOther NotesProtecting group reagent; brings two alcohols in close contact for "tethering technique"ПараметрыQuality Level 100, assay 97.0% (GC) refractive index n20/D 1.444 bp 66 °C/27 mmHg (lit.) density 1.026 g/mL at 20 °C (lit.) SMILES string CC(C)[Si](Cl)(Cl)C(C)C InChI 1S/C6H14Cl2Si/c1-5(2)9(7,8)6(3)4/h5-6H,1-4H3 InChI key GSENNYNYEKCQGA-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS05 signalword Danger hcodes H226 - H314 pcodes P280 - P305 + P351 + P338 - P310 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 2986 3(8) / PGII WGK Germany WGK 3 Flash Point F 109.4 °F - closed cup Flash Point C 43 °C - closed cup Узнать цену -
Dichlorodiphenylsilane
Empirical Formula (Hill Notation): C12H10Cl2Si Linear Formula: (C6H5)2SiCl2 CAS Number: 80-10-4 Molecular Weight: 253.20 Beilstein/REAXYS Number: 609882 EC Number: 201-251-0 MDL number: MFCD00000489 PubChem Substance ID: 24867569 NACRES: NA.22
Кат. номер 440124-500ML 440124-100ML ПараметрыQuality Level 100, vapor density >1 (vs air) vapor pressure 2 mmHg ( 125 °C) assay 95% form liquid refractive index n20/D 1.578 (lit.) bp 305 °C (lit.) density 1.204 g/mL at 25 °C (lit.) SMILES string Cl[Si](Cl)(c1ccccc1)c2ccccc2 InChI 1S/C12H10Cl2Si/c13-15(14,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H InChI key OSXYHAQZDCICNX-UHFFFAOYSA-N
Safety Informationpictograms GHS05,GHS06 signalword Danger hcodes H310 - H314 pcodes P280 - P301 + P330 + P331 - P303 + P361 + P353 - P305 + P351 + P338 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 1769 8 / PGII WGK Germany WGK 1 Flash Point F 287.6 °F - closed cup Flash Point C 142 °C - closed cup Узнать цену -
Dichloromethylsilane
Empirical Formula (Hill Notation): CH4Cl2Si Linear Formula: CH3SiHCl2 CAS Number: 75-54-7 Molecular Weight: 115.03 Beilstein/REAXYS Number: 1071194 EC Number: 200-877-1 MDL number: MFCD00000494 PubChem Substance ID: 24867579 NACRES: NA.22
PackagingКат. номер 440248-100ML 440248-PZ 440248-1L 440248-1000ML 440248-250ML
1 L in Sure/Seal™
100 mL in Sure/Seal™
View returnable container options,.ПараметрыQuality Level 200, vapor density 4 (vs air) vapor pressure 6.79 psi ( 20 °C) assay 97% autoignition temp. 471 °F expl. lim. >55 % refractive index n20/D 1.398 (lit.) bp 41 °C (lit.) mp 93 °C (lit.) density 1.105 g/mL at 25 °C (lit.) storage temp. 2-8°C SMILES string C[SiH](Cl)Cl InChI 1S/CH4Cl2Si/c1-4(2)3/h4H,1H3 InChI key NWKBSEBOBPHMKL-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS05,GHS06 signalword Danger hcodes H225 - H261 - H301 + H331 - H314 pcodes P210 - P231 + P232 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 Supp Hazards EUH014 - EUH071 Personal Protective Equipment Faceshields,, Gloves,, Goggles, RIDADR UN1242 - class 4.3 - PG 1 - Methyldichlorosilane WGK Germany WGK 1 Flash Point F -18.4 °F Flash Point C -28 °C Узнать цену -
Diethyl carbonate
Empirical Formula (Hill Notation): C5H10O3 Linear Formula: (C2H5O)2CO CAS Number: 105-58-8 Molecular Weight: 118.13 Beilstein/REAXYS Number: 956591 EC Number: 203-311-1 MDL number: MFCD00009107 PubChem Substance ID: 24894264 NACRES: NA.22
Кат. номер D91551-2.5L D91551-18L D91551-4L D91551-250ML D91551-1L General descriptionWe are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is used as a greener reagent. Click here, for more information.ApplicationDiethyl carbonate (DEC) is generally used in the C-alkoxycarbonylation of enolate anions, aryl and alkyl cyanides. It reacts with 1,2-amino alcohols to yield corresponding 2-oxazolidinones. Additionally, DEC is also used as a component of electrolyte solution in lithium ion batteries.
Packaging
1, 4 L in glass bottle
18 L in VerSA-Flow™
250 mL in glass bottleПараметрыvapor density 4.1 (vs air) Quality Level 100, vapor pressure 10 mmHg ( 23.8 °C), 59 mmHg ( 37.8 °C) assay 99% greener alternative product characteristics Less Hazardous Chemical Syntheses
Safer Solvents and Auxiliaries
Design for Degradation
Learn more about the Principles of Green Chemistry,.refractive index n20/D 1.384 (lit.) bp 126-128 °C (lit.) mp 43 °C (lit.) density 0.975 g/mL at 25 °C (lit.) greener alternative category Aligned, SMILES string O=C(OCC)OCC InChI 1S/C5H10O3/c1-3-7-5(6)8-4-2/h3-4H2,1-2H3 InChI key OIFBSDVPJOWBCH-UHFFFAOYSA-N
Safety Informationpictograms GHS02 signalword Warning hcodes H226 pcodes P210 - P233 - P303 + P361 + P353 - P370 + P378 - P403 + P235 - P501 Personal Protective Equipment Eyeshields,, Faceshields,, Gloves,, type ABEK (EN14387) respirator filter, RIDADR UN 2366 3 / PGIII WGK Germany WGK 1 Flash Point F 77.0 °F - closed cup Flash Point C 25 °C - closed cup Узнать цену -
Diiodosilane
Empirical Formula (Hill Notation): H2I2Si Linear Formula: SiH2I2 CAS Number: 13760-02-6 Molecular Weight: 283.91 MDL number: MFCD00075171 PubChem Substance ID: 24860695 NACRES: NA.22
Кат. номер 339873-5G 339873-1G ApplicationReagent involved in reductive iodination for synthesis of [18F]FDOPA
Packaging
5 g in ampuleПараметрыcontains copper as stabilizer Quality Level 100, bp 56-60 °C/25 mmHg (lit.) density 2.834 g/mL at 25 °C (lit.) storage temp. 2-8°C SMILES string I[Si]([H])([H])I InChI 1S/H2I2Si/c1-3-2/h3H2 InChI key AIHCVGFMFDEUMO-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS05,GHS07 signalword Danger hcodes H226 - H260 - H302 + H312 + H332 - H314 pcodes P210 - P231 + P232 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 Supp Hazards EUH014 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 3129 8(4.3) / PGI WGK Germany WGK 3 Flash Point F 100.4 °F - closed cup Flash Point C 38 °C - closed cup Узнать цену -
Diisopropylsilyl bis(trifluoromethanesulfonate)
Empirical Formula (Hill Notation): C8H14F6O6S2Si Linear Formula: (CF3SO3)2Si[CH(CH3)2]2 CAS Number: 85272-30-6 Molecular Weight: 412.40 Beilstein/REAXYS Number: 3567500 MDL number: MFCD00043111 PubChem Substance ID: 24863413 NACRES: NA.22
Кат. номер 375942-5G 375942-25G 375942-1G ПараметрыQuality Level 200, assay 96% refractive index n20/D 1.382 (lit.) bp 85-86 °C/2 mmHg (lit.) density 1.396 g/mL at 25 °C (lit.) SMILES string CC(C)[Si](OS(=O)(=O)C(F)(F)F)(OS(=O)(=O)C(F)(F)F)C(C)C InChI 1S/C8H14F6O6S2Si/c1-5(2)23(6(3)4,19-21(15,16)7(9,10)11)20-22(17,18)8(12,13)14/h5-6H,1-4H3 InChI key BHZPNBNSRVSTBW-UHFFFAOYSA-N
Safety Informationpictograms GHS05 signalword Danger hcodes H314 pcodes P280 - P305 + P351 + P338 - P310 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 3265 8 / PGII WGK Germany WGK 3 Flash Point F 235.4 °F - closed cup Flash Point C 113 °C - closed cup Узнать цену -
Ethanesulfonyl chloride
Empirical Formula (Hill Notation): C2H5ClO2S Linear Formula: CH3CH2SO2Cl CAS Number: 594-44-5 Molecular Weight: 128.58 Beilstein/REAXYS Number: 773865 EC Number: 209-842-5 MDL number: MFCD00007460 PubChem Substance ID: 24870741 NACRES: NA.22
Кат. номер 471542-100ML 471542-500ML 471542-1L 471542-5L 471542-18L 471542-2L 471542-25ML ПараметрыQuality Level 100, assay 99% refractive index n20/D 1.452 (lit.) bp 177 °C (lit.) density 1.357 g/mL at 25 °C (lit.) SMILES string CCS(Cl)(=O)=O InChI 1S/C2H5ClO2S/c1-2-6(3,4)5/h2H2,1H3 InChI key FRYHCSODNHYDPU-UHFFFAOYSA-N
Safety Informationpictograms GHS05,GHS06 signalword Danger hcodes H302 + H312 - H314 - H330 - H335 pcodes P260 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 2927 8(6.1) / PGII WGK Germany WGK 2 Flash Point F 181.4 °F - closed cup Flash Point C 83 °C - closed cup Узнать цену -
Ethyl 1H-imidazole-1-carboxylate
Empirical Formula (Hill Notation): C6H8N2O2 CAS Number: 19213-72-0 Molecular Weight: 140.14 EC Number: 242-883-7 MDL number: MFCD00014498 PubChem Substance ID: 329765933 NACRES: NA.22
Кат. номер 748773-1G 748773-1G-KC 748773-5G 748773-25G Параметрыrefractive index n20/D 1.472 Quality Level 200, density 1.162 g/mL at 25 °C storage temp. 2-8°C SMILES string CCOC(=O)n1ccnc1 InChI 1S/C6H8N2O2/c1-2-10-6(9)8-4-3-7-5-8/h3-5H,2H2,1H3 InChI key YICRPEGTQDSFEX-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F 219.9 °F Flash Point C 104.4 °C Узнать цену -
Ethyl N-Boc-oxamidate
Empirical Formula (Hill Notation): C9H15NO5 CAS Number: 216959-34-1 Molecular Weight: 217.22 Beilstein/REAXYS Number: 8201747 MDL number: MFCD01631201 PubChem Substance ID: 57647637 NACRES: NA.22
PackagingКат. номер 17346-5G 17346-25G
5 g in glass bottleOther NotesReagent for transforming alcohols into BOC-protected amines by Mitsunobu reaction (PPh3/DEAD); prim and sec alcohols (inversion of configuration) give good yieldsПараметрыassay 97.0% application(s) peptide synthesis: suitable refractive index n20/D 1.449 storage temp. 20°C SMILES string CCOC(=O)C(=O)NC(=O)OC(C)(C)C InChI 1S/C9H15NO5/c1-5-14-7(12)6(11)10-8(13)15-9(2,3)4/h5H2,1-4H3,(H,10,11,13) InChI key DSDQWJVXMDHQLK-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Ethyl vinyl ether
Empirical Formula (Hill Notation): C4H8O Linear Formula: C2H5OCH=CH2 CAS Number: 109-92-2 Molecular Weight: 72.11 Beilstein/REAXYS Number: 605351 EC Number: 203-718-4 MDL number: MFCD00009248 eCl@ss: 39021025 PubChem Substance ID: 24866417 NACRES: NA.23
Кат. номер 422177-250ML 422177-1L ПараметрыQuality Level 200, assay 99% contains 0.1% KOH as stabilizer, 0.1% potassium hydroxide as stabilizer refractive index n20/D 1.376 (lit.) bp 33 °C (lit.) mp 116 °C (lit.) density 0.753 g/mL at 25 °C (lit.) storage temp. 2-8°C SMILES string CCOC=C InChI 1S/C4H8O/c1-3-5-4-2/h3H,1,4H2,2H3 InChI key FJKIXWOMBXYWOQ-UHFFFAOYSA-N
Safety Informationpictograms GHS02 signalword Danger hcodes H224 pcodes P210 - P403 + P233 Personal Protective Equipment Eyeshields,, Faceshields,, Gloves, RIDADR UN1302 - class 3 - PG 1 - Vinyl ethyl ether, stabilized WGK Germany WGK 1 Flash Point F -49.0 °F Flash Point C -45 °C Узнать цену -
Ethylene glycol
Empirical Formula (Hill Notation): C2H6O2 Linear Formula: HOCH2CH2OH CAS Number: 107-21-1 Molecular Weight: 62.07 Beilstein/REAXYS Number: 505945 EC Number: 203-473-3 MDL number: MFCD00002885 eCl@ss: 39020501 PubChem Substance ID: 57648687 NACRES: NA.21
Кат. номер 324558-PZ 324558-100ML 324558-VAR 324558-6X1L 324558-12X100ML 324558-1L 324558-2L 324558-4X2L General descriptionEthylene glycol is the major component of antifreeze preparations.ApplicationEthylene glycol may be used in the preparation of spiroborate esters by reacting with chiral 1,2-aminoalcohols in the presence of triisopropyl borate. It may also be used as a solvent in the preparation of tris(2,2′-bipyrazyl)ruthenium(II) chloride by the reaction of 2,2′-bipyrazine with ruthenium(III) chloride.Packaging1, 6×1, 2 L in Sure/Seal™
100 mL in Sure/Seal™Other NotesTandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 324558.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.ПараметрыQuality Level 100 grade anhydrous vapor density 2.1 (vs air) vapor pressure 0.08 mmHg ( 20 °C) assay 99.8% form liquid autoignition temp. 752 °F expl. lim. 15.3 % impurities <0.003% water, <0.005% water (100 mL pkg) refractive index n20/D 1.431 (lit.) bp 195-198 °C mp 13 °C (lit.) density 1.113 g/mL at 25 °C (lit.) SMILES string OCCO InChI 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2 InChI key LYCAIKOWRPUZTN-UHFFFAOYSA-N
Safety Informationpictograms GHS07,GHS08 signalword Warning hcodes H302 - H373 pcodes P301 + P312 + P330 - P314 Target Organs Kidney Personal Protective Equipment Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter RIDADR UN 3082 9 / PGIII WGK Germany WGK 1 Узнать цену -
Ethylene glycol polymer-bound
PubChem Substance ID: 24845590
Кат. номер 3773-VAR 3773-5G 3773-25G Other NotesPolymer supported protecting-group reagent for aldehydes and ketonesПараметрыextent of labeling ~2.8 mmol/g diol loading matrix crosslinked with 2% DVB particle size 200-400 mesh
Safety InformationPersonal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany 3 Узнать цену -
Fmoc isothiocyanate
Empirical Formula (Hill Notation): C16H11NO2S CAS Number: 199915-38-3 Molecular Weight: 281.33 Beilstein/REAXYS Number: 7930648 MDL number: MFCD01861169 PubChem Substance ID: 57646854 NACRES: NA.22
Кат. номер 10919-5G 10919-1G ApplicationFmoc isothiocyanate can be used:- As a starting material in the preparation of biologically relevant pharmacophores named N-aryl-N-carboalkoxy guanidines.
- In one of the intermediate steps for the synthesis of N-aryl-N-thiazolyl derivatives.
- To synthesize cyclic isothiourea derivatives as potent neuropeptide Y (NPY) Y1 receptor antagonists.
- To prepare 2-aminothiazoles, aminobenz-imidazole conjugated thiazoles, and thiazole derived cyclopeptides.
Packaging
5 g in poly bottle
1 g in poly tubeOther NotesReagent for the synthesis of substituted thioureas from aminesПараметрыQuality Level 100, assay 85% (coupling to amines), 98.0% (CHN) application(s) peptide synthesis: suitable solubility ethanol: soluble fluorescence ex 264 nm; em 313 nm functional group Fmoc storage temp. 20°C SMILES string O=C(OCC1c2ccccc2-c3ccccc13)N=C=S InChI 1S/C16H11NO2S/c18-16(17-10-20)19-9-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15/h1-8,15H,9H2 InChI key DHMYULZVFHHEHE-UHFFFAOYSA-N
Safety Informationpictograms GHS05,GHS07 signalword Danger hcodes H315 - H318 - H335 pcodes P261 - P280 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Fmoc N-hydroxysuccinimide ester
Empirical Formula (Hill Notation): C19H15NO5 CAS Number: 82911-69-1 Molecular Weight: 337.33 Beilstein/REAXYS Number: 3569540 EC Number: 433-520-5 MDL number: MFCD00010733 PubChem Substance ID: 57650882 NACRES: NA.22
PackagingКат. номер 46920-5G-F 46920-25G-F 46920-100G-F
5, 25, 100 g in glass bottleApplicationMost efficient reagent for the selective preparation of N-(9-fluorenylmethoxycarbonyl) derivatives of hydroxy-amino acids in high yield. Dipeptide formation is lower than with the chloroformate, Fmoc-Cl. It has been employed in the synthesis of glycopeptides.ПараметрыQuality Level 200, assay 98.0% (HPLC) application(s) peptide synthesis: suitable mp 150-153 °C (lit.) functional group Fmoc storage temp. 2-8°C SMILES string O=C(OCC1c2ccccc2-c3ccccc13)ON4C(=O)CCC4=O InChI 1S/C19H15NO5/c21-17-9-10-18(22)20(17)25-19(23)24-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2 InChI key WMSUFWLPZLCIHP-UHFFFAOYSA-N
Safety Informationpictograms GHS07,GHS09 signalword Warning hcodes H302 - H317 - H411 pcodes P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352 Personal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR UN 3077 9 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Fmoc-Phe(4-Br)-OH 672637-1G
Empirical Formula (Hill Notation): C24H20BrNO4 Molecular Weight: 466.32 MDL number: MFCD00273460 PubChem Substance ID: 329760520 NACRES: NA.26 ПараметрыQuality Level 100, assay ≥98.0% reaction suitability reaction type: Fmoc solid-phase peptide synthesis application(s) peptide synthesis: suitable functional group Fmoc SMILES string OC(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)OCC2c3ccccc3-c4ccccc24 InChI 1S/C24H20BrNO4/c25-16-11-9-15(10-12-16)13-22(23(27)28)26-24(29)30-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14H2,(H,26,29)(H,27,28)/t22-/m0/s1 InChI key TVBAVBWXRDHONF-QFIPXVFZSA-N
Safety Informationhcodes H413 Personal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Iodotrimethylsilane
Empirical Formula (Hill Notation): C3H9ISi Linear Formula: (CH3)3SiI CAS Number: 16029-98-4 Molecular Weight: 200.09 Beilstein/REAXYS Number: 1731136 EC Number: 240-171-0 MDL number: MFCD00001028 PubChem Substance ID: 24851696 NACRES: NA.22
Кат. номер 195529-100G 195529-5G 195529-25G General descriptionIodotrimethylsilane is a multipurpose reagent used in various organic reactions. It is used for the dealkylation of few compounds like lactones, ethers, acetals, and carbamates and trimethylsilylating agent for the synthesis of silyl imino esters, alkyl and alkenyl silanes, etc. It also acts as a Lewis acid catalyst and as a reducing agent in many organic reactions.
Packaging
5, 25, 100 g in ampuleApplicationReagent was recently reported to convert allyl- and benzylphosphotriesters to the corresponding iodides.
Efficient reagent for cleaving ethers, esters, carbamates, ketals, and lactones.
For the introduction of the TMS group, e.g., TMS enol ethers. Key reagent for the selective deprotection of an N-Cbz group in the presence of a trimethyltin moiety.ПараметрыQuality Level 300 assay 97% contains copper as stabilizer refractive index n20/D 1.471 (lit.) bp 106 °C (lit.) density 1.406 g/mL at 25 °C (lit.) storage temp. 20°C SMILES string C[Si](C)(C)I InChI 1S/C3H9ISi/c1-5(2,3)4/h1-3H3 InChI key CSRZQMIRAZTJOY-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS05 signalword Danger hcodes H225 - H314 pcodes P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338 Supp Hazards EUH014 Personal Protective Equipment Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter RIDADR UN 2924 8(3) / PGII WGK Germany WGK 3 Flash Point F -23.8 °F - closed cup Flash Point C -31 °C - closed cup Узнать цену -
Isopropyl 1H-imidazole-1-carboxylate
Empirical Formula (Hill Notation): C7H10N2O2 CAS Number: 82998-18-3 Molecular Weight: 154.17 MDL number: MFCD21336269 PubChem Substance ID: 329765932 NACRES: NA.22
Кат. номер 748765-25G 748765-1G 748765-5G ПараметрыQuality Level 200, assay 95% refractive index n20/D 1.467 density 1.098 g/mL at 25 °C storage temp. 2-8°C SMILES string CC(C)OC(=O)n1ccnc1 InChI 1S/C7H10N2O2/c1-6(2)11-7(10)9-4-3-8-5-9/h3-6H,1-2H3 InChI key UAILNBAKJABHNQ-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F 226.4 °F Flash Point C 108 °C Узнать цену -
Lenalidomide
Empirical Formula (Hill Notation): C13H13N3O3 CAS Number: 191732-72-6 Molecular Weight: 259.26 MDL number: MFCD07772307 NACRES: NA.22
Кат. номер 901558-1G 901558-100MG 901558-5G ApplicationLenalidomide is a ligand demonstrated to bind the Cereblon (CRBN) protein. Lenalidomide, along with other thalidomide derivatives, are useful for constructing small molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology,. Explore protein degrader building blocks,, E3 ligase ligand-linker conjugates that simplify the synthesis and library generation of PROTACs.
.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs,
Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells,
The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay ≥95% form powder mp 265-268 °C storage temp. 2-8°C SMILES string O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N, O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N InChI 1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18) InChI key GOTYRUGSSMKFNF-UHFFFAOYSA-N
Safety Informationpictograms GHS08 signalword Warning hcodes H361d - H373 pcodes P201 - P308 + P313 Target Organs Blood RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Lithium thioethoxide 717991-5G
Empirical Formula (Hill Notation): C2H5LiS CAS Number: 30383-01-8 Molecular Weight: 68.07 MDL number: MFCD16621449 PubChem Substance ID: 329763541 NACRES: NA.22 ApplicationReactant for preparation of:- Microwave-assisted cleavage of aryl methyl ethers
- Triply thiolate-bridged diiron complexes
- (+)-batzelladine A and (-)-batzelladine D
Packaging
5 g in glass bottleПараметрыQuality Level 100, assay 80% mp 316-333 °C SMILES string [Li]SCC InChI 1S/C2H6S.Li/c1-2-3;/h3H,2H2,1H3;/q;+1/p-1 InChI key JPSNJFMTQIIVFG-UHFFFAOYSA-M
Safety Informationpictograms GHS02,GHS05 signalword Danger hcodes H228 - H314 pcodes P210 - P280 - P305 + P351 + P338 - P310 Supp Hazards EUH014 RIDADR UN 3206 8(4.2) / PGII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Methanesulfonyl bromide
Empirical Formula (Hill Notation): CH3BrO2S CAS Number: 41138-92-5 Molecular Weight: 159.00 MDL number: MFCD05865252 PubChem Substance ID: 329747982 NACRES: NA.22
Кат. номер 4825-5ML-F 4825-VAR-F 4825-25ML-F ПараметрыQuality Level 100, assay 98.0% refractive index n20/D 1.510 density 1.954 g/mL at 20 °C (lit.) SMILES string CS(Br)(=O)=O InChI 1S/CH3BrO2S/c1-5(2,3)4/h1H3 InChI key ITYJDNHFRZSTJY-UHFFFAOYSA-N
Safety Informationpictograms GHS05,GHS06 signalword Danger hcodes H300 + H330 - H314 pcodes P280 - P301 + P310 + P330 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 3390 8(6.1) / PGI WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Methanesulfonyl chloride
Empirical Formula (Hill Notation): CH3ClO2S Linear Formula: CH3SO2Cl CAS Number: 124-63-0 Molecular Weight: 114.55 Beilstein/REAXYS Number: 506297 EC Number: 204-706-1 MDL number: MFCD00007454 PubChem Substance ID: 24870710
Кат. номер 471259-25ML 471259-100ML 471259-2L 471259-5ML 471259-1L 471259-500ML 471259-5L ApplicationMethanesulfonyl chloride can be used for the mesylation of primary alcohols to synthesize the corresponding methanesulfonates. It may also be used for the conversion of amines to the corresponding sulfonamides.Packaging5, 100, 500 mL in glass bottle
2 L in poly bottle
1 L in glass bottleПараметрыQuality Level 200 assay 99.7% refractive index n20/D 1.452 (lit.) bp 60 °C/21 mmHg (lit.) density 1.48 g/mL at 25 °C (lit.) storage temp. 2-8°C SMILES string CS(Cl)(=O)=O InChI 1S/CH3ClO2S/c1-5(2,3)4/h1H3 InChI key QARBMVPHQWIHKH-UHFFFAOYSA-N
Safety Informationpictograms GHS05,GHS06 signalword Danger hcodes H301 + H311 - H314 - H317 - H330 - H335 pcodes P280 - P301 + P310 + P330 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter RIDADR UN 3246 6.1(8) / PGI WGK Germany WGK 2 Flash Point F 235.4 °F - closed cup Flash Point C 113 °C - closed cup Узнать цену -
Methyl 1H-imidazole-1-carboxylate
Empirical Formula (Hill Notation): C5H6N2O2 CAS Number: 61985-23-7 Molecular Weight: 126.11 MDL number: MFCD00585680 PubChem Substance ID: 329765930 NACRES: NA.22
Кат. номер 748730-25G 748730-5G 748730-1G General descriptionMethyl 1H-imidazole-1-carboxylate is a reagent developed by Heller and Sarpong for the amidation and esterification of carboxylic acids chemoselectively.ApplicationMethyl 1H-imidazole-1-carboxylate can be used to prepare fluorous -keto esters, precursors used for the synthesis of fluorinated L-carbidopa derivatives.
Packaging
5, 25 g in poly bottleПараметрыQuality Level 200, assay 95% mp 38-44 °C storage temp. 20°C SMILES string COC(=O)n1ccnc1 InChI 1S/C5H6N2O2/c1-9-5(8)7-3-2-6-4-7/h2-4H,1H3 InChI key JQCPMLVMNQVRCC-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F 194.0 °F Flash Point C 90 °C Узнать цену -
Methyltrichlorosilane
Empirical Formula (Hill Notation): CH3Cl3Si Linear Formula: CH3SiCl3 CAS Number: 75-79-6 Molecular Weight: 149.48 Beilstein/REAXYS Number: 1361381 EC Number: 200-902-6 MDL number: MFCD00000481 PubChem Substance ID: 24897271 NACRES: NA.22
Кат. номер M85301-PZ M85301-500G M85301-5G M85301-100G ApplicationMethyltrichlorosilane (MTS) can be used:- As a reagent for the surface-functionalization of fabrics and mesoporous materials to increase their hydrophobicity.
- As a source of silicon to synthesize silica doped carbon nanotubes.
Packaging
100, 500 g in Sure/Seal™
5 g in glass bottleПараметрыvapor density 5.2 (vs air) Quality Level 100, vapor pressure 150 mmHg ( 25 °C) assay 99% form liquid autoignition temp. >760 °F expl. lim. 11.9 % refractive index n20/D 1.411 (lit.) bp 66 °C (lit.) density 1.273 g/mL at 25 °C (lit.) SMILES string C[Si](Cl)(Cl)Cl InChI 1S/CH3Cl3Si/c1-5(2,3)4/h1H3 InChI key JLUFWMXJHAVVNN-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS05,GHS06 signalword Danger hcodes H225 - H302 + H312 - H314 - H331 pcodes P210 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P311 - P305 + P351 + P338 Supp Hazards EUH014 - EUH071 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN1250 - class 3 - PG 2 - Methyltrichlorosilane WGK Germany WGK 1 Flash Point F 46.4 °F - closed cup Flash Point C 8 °C - closed cup Узнать цену -
Methyltrichlorosilane 679208-50G
Empirical Formula (Hill Notation): CH3Cl3Si Linear Formula: CH3SiCl3 CAS Number: 75-79-6 Molecular Weight: 149.48 Beilstein/REAXYS Number: 1361381 EC Number: 200-902-6 MDL number: MFCD00000481 PubChem Substance ID: 24885475 NACRES: NA.23 Параметрыgrade deposition grade Quality Level 100, vapor density 5.2 (vs air) vapor pressure 150 mmHg ( 25 °C) assay 98% (GC), 99.99% (as metals) form liquid autoignition temp. >760 °F expl. lim. 11.9 % refractive index n20/D 1.411 (lit.) bp 66 °C (lit.) density 1.273 g/mL at 25 °C (lit.) SMILES string C[Si](Cl)(Cl)Cl InChI 1S/CH3Cl3Si/c1-5(2,3)4/h1H3 InChI key JLUFWMXJHAVVNN-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS05,GHS06 signalword Danger hcodes H225 - H302 + H312 - H314 - H331 pcodes P210 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P311 - P305 + P351 + P338 Supp Hazards EUH014 - EUH071 RIDADR UN1250 - class 3 - PG 2 - Methyltrichlorosilane WGK Germany WGK 1 Flash Point F 46.4 °F - closed cup Flash Point C 8 °C - closed cup Узнать цену -
N,O-Bis(trimethylsilyl)acetamide
Empirical Formula (Hill Notation): C8H21NOSi2 Linear Formula: CH3C[=NSi(CH3)3]OSi(CH3)3 CAS Number: 10416-59-8 Molecular Weight: 203.43 Beilstein/REAXYS Number: 1306669 EC Number: 233-892-7 MDL number: MFCD00008270 PubChem Substance ID: 24847878 NACRES: NA.22
PackagingКат. номер 128910-100ML 128910-25ML 128910-1L 128910-10ML
1 L in glass bottle
10, 25, 100 mL in glass bottleApplicationDerivatization reagent for GC-MS analysis of phenolic acids in fruits.
Reagent for the regioselective desulfation of polysaccharide sulfates. Also used to prepare trimethylsilyl ethers of carbohydrates and alcohols.Параметрыgrade synthesis grade Quality Level 100 assay 95% refractive index n20/D 1.417 (lit.) bp 71-73 °C/35 mmHg (lit.) density 0.832 g/mL at 20 °C (lit.) SMILES string C\C(O[Si](C)(C)C)=N/[Si](C)(C)C InChI 1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+ InChI key SIOVKLKJSOKLIF-CMDGGOBGSA-N
Safety Informationpictograms GHS02,GHS05,GHS07 signalword Danger hcodes H226 - H302 - H314 pcodes P210 - P233 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338 Supp Hazards EUH014 Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges RIDADR UN 2920 3(8) / PGII WGK Germany WGK 3 Flash Point F 111.2 °F - closed cup Flash Point C 44 °C - closed cup Узнать цену -
N,O-Bis(trimethylsilyl)trifluoroacetamide
Empirical Formula (Hill Notation): C8H18F3NOSi2 Linear Formula: CF3C[=NSi(CH3)3]OSi(CH3)3 CAS Number: 25561-30-2 Molecular Weight: 257.40 Beilstein/REAXYS Number: 2050024 EC Number: 247-103-9 MDL number: MFCD00008269 PubChem Substance ID: 24849493 NACRES: NA.22
PackagingКат. номер 155195-100G 155195-25G 155195-500G 155195-5G
5, 25, 100 g in ampuleApplicationDerivatization reagent employed in a GC-MS analysis of furfural content in foods.Параметрыgrade synthesis grade Quality Level 200, assay 99% refractive index n20/D 1.384 (lit.) bp 45-50 °C/14 mmHg (lit.) density 0.969 g/mL at 25 °C (lit.) SMILES string C[Si](C)(C)O\C(=N\[Si](C)(C)C)C(F)(F)F InChI 1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+ InChI key XCOBLONWWXQEBS-KPKJPENVSA-N
Safety Informationpictograms GHS02,GHS07 signalword Warning hcodes H226 - H315 - H319 pcodes P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 2924 8(3) / PGIII WGK Germany WGK 3 Flash Point F 93.2 °F Flash Point C 34 °C Узнать цену -
N-(3,5-Bis(trifluoromethyl)phenyl)-2-chloroacetamide 912654-100MG
Empirical Formula (Hill Notation): C10H6ClF6NO CAS Number: 790-75-0 Molecular Weight: 305.60 MDL number: MFCD00077474 Application2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as "undruggable," or difficult-to-target, proteins. This fragment electrophile, or "scout" fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC® molecules for targeted protein degradation, as demonstrated by the Cravatt Lab, for E3 ligase discovery.Other NotesTechnology Spotlight: Proteomic Ligandability Assessment,
A road map for prioritizing warheads for cysteine targeting covalent inhibitors,
Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes,
Proteome-wide covalent ligand discovery in native biological systems,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 95% form powder
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 pcodes P302 + P352 - P305 + P351 + P338 WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-(4-Bromophenyl)-N-phenylacrylamide 911798-100MG
Empirical Formula (Hill Notation): C15H12BrNO CAS Number: 1956368-15-2 Molecular Weight: 302.17 ApplicationN-(4-Bromophenyl)-N-phenylacrylamide is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as undruggable, or difficult-to-target, proteins. This fragment electrophile, or scout fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC® molecules for targeted protein degradation, as demonstrated by the Cravatt Lab, for E3 ligase discovery.Other NotesTechnology Spotlight: Proteomic Ligandability Assessment,
Proteome-wide covalent ligand discovery in native biological systems,
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 95% form (Powder or crystals or solid or chunks) storage temp. 2-8°C
Safety InformationWGK Germany WGK 3 Узнать цену -
N-(Benzyloxycarbonyloxy)succinimide
Empirical Formula (Hill Notation): C12H11NO5 CAS Number: 13139-17-8 Molecular Weight: 249.22 Beilstein/REAXYS Number: 1387927 EC Number: 236-075-3 MDL number: MFCD00005513 PubChem Substance ID: 24853653 NACRES: NA.22
Кат. номер 227781-100G 227781-25G 227781-250G 227781-5G ApplicationN-(Benzyloxycarbonyloxy)succinimide (Cbz-OSu) is a common reagent for the carboxybenzyl protection of amines. This reaction is one of the key synthetic steps in the synthesis of:- Enantiomers of cyclic methionine analogs viz, (R)-and (S)-3-aminotetrahydrothiophene- 3-carboxylic acid.
- 1-H-Spiro-(indoline-3,4-piperidine) and its derivatives.
- Total synthesis of (-)-diazonamide A. and (-)-sanglifehrin A.
Cbz-OSu is widely employed to protect amino acid residues in peptide synthesis. It can also be used in N-trans diprotection of cyclen regioselectively.
Reagent for the selective introduction of the Z-amino protection in amino acids; and in aminoglycoside antibiotics.
Packaging
25, 100, 250 g in poly bottleПараметрыQuality Level 200, assay 98% application(s) peptide synthesis: suitable mp 80-82 °C (lit.) SMILES string O=C(OCc1ccccc1)ON2C(=O)CCC2=O InChI 1S/C12H11NO5/c14-10-6-7-11(15)13(10)18-12(16)17-8-9-4-2-1-3-5-9/h1-5H,6-8H2 InChI key MJSHDCCLFGOEIK-UHFFFAOYSA-N
Safety InformationPersonal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine
Empirical Formula (Hill Notation): C13H23NOSi Linear Formula: C6H5CH2N(CH2OCH3)CH2Si(CH3)3 CAS Number: 93102-05-7 Molecular Weight: 237.41 MDL number: MFCD00674005 PubChem Substance ID: 24866346 NACRES: NA.22
PackagingКат. номер 420697-100G 420697-25G 420697-5G 420697-1G
5, 25, 100 g in glass bottleApplicationReacted in asymmetric 1,3-dipolar cycloadditions in the practical, large-scale synthesis of chiral pyrrolidines.
Forms azomethine ylides which readily undergo [3+2] cycloaddition to ,-unsaturated esters affording N-benzyl substituted pyrrolidines in good yields.ПараметрыQuality Level 100, assay 96% refractive index n20/D 1.492 (lit.) bp 76 °C/0.3 mmHg (lit.) density 0.928 g/mL at 25 °C (lit.) SMILES string COCN(Cc1ccccc1)C[Si](C)(C)C InChI 1S/C13H23NOSi/c1-15-11-14(12-16(2,3)4)10-13-8-6-5-7-9-13/h5-9H,10-12H2,1-4H3 InChI key RPZAAFUKDPKTKP-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment Eyeshields,, Gloves,, type ABEK (EN14387) respirator filter, RIDADR NA 1993 / PGIII WGK Germany WGK 3 Flash Point F 150.8 °F - closed cup Flash Point C 66 °C - closed cup Узнать цену -
N-Boc-N-TFA-pyrazole-1-carboxamidine ALD00592-1G
Empirical Formula (Hill Notation): C11H13F3N4O3 Molecular Weight: 306.24 ApplicationPowerful guanidinylation reagent from the Baran Lab, developed for the installation of monoprotected boc-guanidine on primary and secondary amines, particularly electron-deficient and hindered amines,.
Packaging
1 g in glass bottleOther Notes11-Step Total Synthesis of Araiosamines,ПараметрыQuality Level 100, assay 95% form powder or crystals application(s) peptide synthesis: suitable mp 120-125 °C storage temp. 20°C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-Boc-O-tosylhydroxylamine
Empirical Formula (Hill Notation): C12H17NO5S CAS Number: 105838-14-0 Molecular Weight: 287.33 MDL number: MFCD22201097 PubChem Substance ID: 329767730 NACRES: NA.22
Кат. номер 775037-5G 775037-1G ApplicationElectrophilic N-amination of aryl and alkyl amines.
Packaging
1, 5 g in glass bottleПараметрыQuality Level 100, assay 95% storage temp. 2-8°C SMILES string Cc1ccc(cc1)S(=O)(=O)ONC(=O)OC(C)(C)C InChI 1S/C12H17NO5S/c1-9-5-7-10(8-6-9)19(15,16)18-13-11(14)17-12(2,3)4/h5-8H,1-4H3,(H,13,14) InChI key WZDPZKPHVNFUKB-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 - H315 - H317 - H319 - H335 pcodes P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-Ethyl-N-isopropylpropan-2-aminium 4-oxo-3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)-1,5-dioxaspiro[5.5]undec-2-en-2-olate 900351-1G
Empirical Formula (Hill Notation): C24H30F7NO4 Molecular Weight: 529.49 NACRES: NA.22 ApplicationThis compound undergoes cycloreversion to form the fluoro(hetero)aryl ketene, which undergoes efficient coupling with nucleophiles and allows rapid incorporation of highly fluorinated α-fluoro(hetero)aryl acetic acid derivatives.
Packaging
1 g in glass insertOther NotesSelective Perfluoro- and Polyfluoroarylation of Meldrums Acid,ПараметрыQuality Level 100, form powder or crystals mp 89 °C storage temp. 2-8°C
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-Methoxy-N-methyl-1H-imidazole-1-carboxamide
Empirical Formula (Hill Notation): C6H9N3O2 CAS Number: 862873-06-1 Molecular Weight: 155.15 MDL number: MFCD21608484 PubChem Substance ID: 329765937 NACRES: NA.22
Кат. номер 748838-25G 748838-5G 748838-1G ApplicationN-Methoxy-N-methyl-1H-imidazole-1-carboxamide (or N-methoxy-N-methylcarbamoylimidazole) can be used as a reagent to prepare:- N-methoxy-N-methylcyanoformamide by reacting with trimethylsilyl cyanide.
- Esters and amides via chemoselective esterification and amidation of carboxylic acids.
- Carbamoylimidazolium iodides and their derivatives such as ureas, thioureas, carbamates, and amides upon reacting with amines, alcohols, thiols, and carboxylic acids.
Packaging
25 g in glass bottle
5 g in poly bottleПараметрыQuality Level 200, assay 95% refractive index n20/D 1.508 density 1.204 g/mL at 25 °C storage temp. 2-8°C SMILES string CON(C)C(=O)n1ccnc1 InChI 1S/C6H9N3O2/c1-8(11-2)6(10)9-4-3-7-5-9/h3-5H,1-2H3 InChI key DOQREVDTYAHWSN-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-Methyl-N-(trimethylsilyl)trifluoroacetamide
Empirical Formula (Hill Notation): C6H12F3NOSi Linear Formula: CF3CON(CH3)Si(CH3)3 CAS Number: 24589-78-4 Molecular Weight: 199.25 Beilstein/REAXYS Number: 1941550 EC Number: 246-331-6 MDL number: MFCD00000411 PubChem Substance ID: 57654411 NACRES: NA.25
PackagingКат. номер M7891-5G M7891-10X1ML M7891-25G M7891-1ML M7891-1ML-KC M7891-1AMP M7891-10AMP
Sealed ampules contain 1 ml. Gram sizes are in screw-cap bottles.Legal InformationLiChropur is a trademark of Merck KGaA, Darmstadt, GermanyПараметрыQuality Level 100 vapor density >1 (vs air) vapor pressure 8.8 mmHg ( 27 °C) product line BioReagent quality for silylations, LiChropur™ reaction suitability reaction type: Silylations, reagent type: derivatization reagent application(s) gas chromatography (GC): suitable refractive index n20/D 1.38 (lit.) bp 130-132 °C (lit.) density 1.07 g/mL at 25 °C (lit.), 1.075 g/mL at 25 °C (lit.) storage temp. 2-8°C SMILES string CN(C(=O)C(F)(F)F)[Si](C)(C)C InChI 1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3 InChI key MSPCIZMDDUQPGJ-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS07 signalword Warning hcodes H226 - H315 - H319 - H335 pcodes P210 - P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter RIDADR UN 1993C 3 / PGIII WGK Germany WGK 3 Flash Point F 78.8 °F - closed cup Flash Point C 26 °C - closed cup Узнать цену -
N-Methylated pomalidomide 901494-25MG
Empirical Formula (Hill Notation): C14H13N3O4 CAS Number: 1352827-50-9 Molecular Weight: 287.27 NACRES: NA.22 ApplicationN-Methylated pomalidomide is a ligand used as a negative control for pomalidomide (P0018,) in the recruitment of the Cereblon (CRBN) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 98% form powder or crystals shipped in wet ice storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3N)=O)N(C)C1=O, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3N)=O)N(C)C1=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide
Empirical Formula (Hill Notation): C9H18F3NOSi Linear Formula: CF3CON(CH3)Si(CH3)2C(CH3)3 CAS Number: 77377-52-7 Molecular Weight: 241.33 Beilstein/REAXYS Number: 3606546 MDL number: MFCD00009671 PubChem Substance ID: 24864624 NACRES: NA.22
Кат. номер 394882-10X1ML 394882-5ML 394882-1ML 394882-100ML 394882-25ML 394882-INTR 394882-10ML ApplicationN-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA) can be used as an efficient silylating agent for different alcohols, thiols, phenols, carboxylic acids, amines, and amides. It can also be used to functionalize multi-walled carbon nanotubes (MWCNTs) with polar groups. MTBSTFA is reportedly much less moisture-sensitive than other silylating reagents used for GLC derivatization.
Packaging
5, 25, 100 mL in glass bottle
10×1 mL in ampuleПараметрыgrade derivatization grade Quality Level 200, assay >97% refractive index n20/D 1.402 (lit.) bp 172-175 °C (lit.) density 1.036 g/mL at 25 °C (lit.) storage temp. 2-8°C SMILES string CN(C(=O)C(F)(F)F)[Si](C)(C)C(C)(C)C InChI 1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3 InChI key QRKUHYFDBWGLHJ-UHFFFAOYSA-N
Safety Informationpictograms GHS02 signalword Warning hcodes H226 pcodes P210 - P233 - P240 - P241 - P242 - P243 Personal Protective Equipment Eyeshields,, Faceshields,, Gloves,, type ABEK (EN14387) respirator filter, RIDADR UN 1993C 3 / PGIII WGK Germany WGK 3 Flash Point F 113.0 °F - closed cup Flash Point C 45 °C - closed cup Узнать цену -
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane
Empirical Formula (Hill Notation): C9H18F3NOSi CAS Number: 77377-52-7 Molecular Weight: 241.33 Beilstein/REAXYS Number: 3606546 MDL number: MFCD00009671 PubChem Substance ID: 24863412
Кат. номер 375934-10ML 375934-5ML 375934-1ML 375934-10X1ML 375934-25ML 375934-1G 375934-250MG ApplicationN-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-butyldimethylchlorosilane is commonly used for the preparation of N-tert-butyldimethylsilyl ethanolamines resulting from the hydrolysis of nitrogen mustards. It is also used for selective O-silylation of N,O-diacylhydroxyl amines.
Packaging
5, 25 mL in glass bottle
10×1 mL in ampuleПараметрыQuality Level 100, assay 95% contains 1% TBDMSCl storage temp. 20°C SMILES string CN(C(=O)C(F)(F)F)[Si](C)(C)C(C)(C)C InChI 1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3 InChI key QRKUHYFDBWGLHJ-UHFFFAOYSA-N
Safety Informationpictograms GHS02,GHS07 signalword Warning hcodes H226 - H315 - H319 pcodes P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338 Personal Protective Equipment Eyeshields,, Faceshields,, Gloves,, type ABEK (EN14387) respirator filter, RIDADR UN 1993C 3 / PGIII WGK Germany WGK 3 Flash Point F 113.0 °F - closed cup Flash Point C 45 °C - closed cup Узнать цену -
NPTC
Empirical Formula (Hill Notation): C16H22N2O5 CAS Number: 2247828-39-1 Molecular Weight: 322.36
Кат. номер 906131-1G 906131-10G ApplicationNPTC is a reagent developed in the Wipf lab to install a Tempoc protecting group. The Tempoc group is useful for protecting primary, secondary, and heterocyclic amines and is complimentary to both Boc and Cbz protecting groups. Tempoc deprotection can be performed under mild reductive conditions with in situ generated Cu(I) species or by thermolysis at 135 °C.Other Notes2,2,6,6-Tetramethylpiperidin-1-yloxycarbonyl: A Protecting Group for Primary, Secondary, and Heterocyclic Amines,Параметрыassay ≥95% form solid storage temp. 2-8°C
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
p-Toluenesulfonyl chloride
Empirical Formula (Hill Notation): C7H7ClO2S Linear Formula: CH3C6H4SO2Cl CAS Number: 98-59-9 Molecular Weight: 190.65 Beilstein/REAXYS Number: 607898 EC Number: 202-684-8 MDL number: MFCD00007450 PubChem Substance ID: 57648053 NACRES: NA.21
Кат. номер 240877-VAR 240877-5G 240877-500G 240877-100G General descriptionp-Toluenesulfonyl chloride is an organic sulfonyl chloride mainly used to convert hydroxyl groups into good leaving group by forming sulfonates.Applicationp-Toluenesulfonyl chloride may be used in the following processes:- In combination with N-methylimidazole for the esterification or thioesterification of carboxylic acids and alcohols or thiols.
- As an additive to enhance the yield of symmetrical biaryls via palladium chloride catalyzed homo-coupling of arylboronic acids in the absence of ligands.
- As a positive chlorine source for the ?-chlorination of ketones.
- Solvent-free tosylation of alcohols and phenols in the presence of heterodoxy acids.
- As an activator for reaction between 2-alkynylbenzaldoxime and phenols to form 1-aroxyisoquinolines in the presence of silver triflate.
- As a catalyst for the solvent-free preparation of symmetrical bis(benzhydryl)ethers from benzhydrols.
Packaging
5 g in glass bottle
100, 500 g in poly bottleLegal InformationReagentPlus is a registered trademark of Sigma-Aldrich Co. LLCПараметрыvapor pressure 1 mmHg ( 88 °C) Quality Level 200, product line ReagentPlus® assay 99% bp 134 °C/10 mmHg (lit.) mp 65-69 °C (lit.) solubility benzene: freely soluble(lit.), chloroform: freely soluble(lit.), ethanol: freely soluble(lit.), water: insoluble(lit.) SMILES string Cc1ccc(cc1)S(Cl)(=O)=O InChI 1S/C7H7ClO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3 InChI key YYROPELSRYBVMQ-UHFFFAOYSA-N
Safety Informationpictograms GHS05,GHS07 signalword Danger hcodes H290 - H315 - H317 - H318 pcodes P280 - P302 + P352 - P305 + P351 + P338 + P310 Personal Protective Equipment Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges, RIDADR UN 3261 8 / PGIII WGK Germany WGK 1 Flash Point F 262.4 °F Flash Point C 128 °C Узнать цену -
p-Tolyltrichlorosilane
Empirical Formula (Hill Notation): C7H7Cl3Si Linear Formula: CH3C6H4SiCl3 CAS Number: 701-35-9 Molecular Weight: 225.57 EC Number: 211-854-0 MDL number: MFCD00045131 PubChem Substance ID: 24866104 NACRES: NA.22
Кат. номер 419354-25G 419354-5G ApplicationSelf-assembled monolayers (SAMs) of p-tolyltrichlorosilane (TTCS) were formed on flexible polymer substrates. p-Tolyltrichlorosilane copolymerized with methylphenyldichlorosilane was grafted on silicon to introduce a structural defect.
Packaging
25 g in glass bottleПараметрыQuality Level 100, assay 95% refractive index n20/D 1.5240 (lit.) bp 218-220 °C (lit.) density 1.273 g/mL at 25 °C (lit.) SMILES string Cc1ccc(cc1)[Si](Cl)(Cl)Cl InChI 1S/C7H7Cl3Si/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3 InChI key WOMUGKOOLXQCTQ-UHFFFAOYSA-N
Safety Informationpictograms GHS05 signalword Danger hcodes H314 pcodes P280 - P305 + P351 + P338 - P310 Supp Hazards EUH014 Personal Protective Equipment Faceshields,, Gloves,, Goggles,, type ABEK (EN14387) respirator filter, RIDADR UN 2987 8 / PGII WGK Germany WGK 3 Flash Point F 210.2 °F - closed cup Flash Point C 99 °C - closed cup Узнать цену -
Pentafluorophenyl acetate
Empirical Formula (Hill Notation): C8H3F5O2 CAS Number: 19220-93-0 Molecular Weight: 226.10 Beilstein/REAXYS Number: 1985849 EC Number: 242-891-0 MDL number: MFCD00015552 PubChem Substance ID: 329768046 NACRES: NA.22
Кат. номер 779512-5G 779512-1G ПараметрыQuality Level 100, assay ≥97.0% (GC) SMILES string CC(=O)Oc1c(F)c(F)c(F)c(F)c1F InChI 1S/C8H3F5O2/c1-2(14)15-8-6(12)4(10)3(9)5(11)7(8)13/h1H3 InChI key ZXTVBLZVILLKPM-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315-H319-H335 pcodes P261-P305 + P351 + P338 RIDADR NONH for all modes of transport WGK Germany 3 Узнать цену -
Pomalidomide-C3-CO2H 901500-50MG
Empirical Formula (Hill Notation): C17H17N3O6 CAS Number: 2225940-47-4 Molecular Weight: 359.33 NACRES: NA.22 ApplicationProtein degrader builiding block Pomalidomide-C3-CO2H enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 95% form powder or crystals shipped in wet ice storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCCC(O)=O)=O)NC1=O, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCCC(O)=O)=O)NC1=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-C3-NH2 hydrochloride 911658-50MG
Empirical Formula (Hill Notation): C16H18N4O4 · xHCl Molecular Weight: 330.34 (free base basis) ApplicationProtein degrader building block Pomalidomide-C3-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant amine for reactivity with an acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form powder storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCCN)=O)NC1=O.Cl, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCCN)=O)NC1=O.Cl
Safety Informationpictograms GHS08 signalword Danger hcodes H360D pcodes P201 - P308 + P313 WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-C6-CO2H 901496-50MG
Empirical Formula (Hill Notation): C20H23N3O6 CAS Number: 2225940-50-9 Molecular Weight: 401.41 NACRES: NA.22 ApplicationProtein degrader builiding block Pomalidomide-C6-CO2H enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыQuality Level 100, assay 98% form powder or crystals storage temp. 2-8°C SMILES string O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=CC=C3NCCCCCCC(O)=O)=O, O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=CC=C3NCCCCCCC(O)=O)=O
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Pomalidomide-C6-NH2 hydrochloride 911666-50MG
Empirical Formula (Hill Notation): C19H24N4O4 · xHCl CAS Number: 2375194-37-7 Molecular Weight: 372.42 (free base basis) ApplicationProtein degrader building block Pomalidomide-C6-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant amine for reactivity with an acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Other NotesTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands,
Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction,
Identification of New Small-Molecule Inducers of Estrogen-related Receptor (ERR) Degradation,
Discovery of MD-224 as a First-in-Class, Highly Potent and Efficacious PROTAC MDM2 Degrader Capable of Achieving Complete and Durable Tumor Regression,Legal InformationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under licenseПараметрыassay 95% form powder storage temp. 2-8°C SMILES string O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCCCCCN)=O)NC1=O.Cl, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCCCCCN)=O)NC1=O.Cl
Safety Informationpictograms GHS08 signalword Danger hcodes H360D pcodes P201 - P308 + P313 WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену
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