Pomalidomide-C6-NH2 hydrochloride 911666-50MG

Empirical Formula (Hill Notation):	C19H24N4O4 · xHCl
CAS Number:	2375194-37-7
Molecular Weight:	372.42 (free base basis)

Protein degrader building block Pomalidomide-C6-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant amine for reactivity with an acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands,
Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction,
Identification of New Small-Molecule Inducers of Estrogen-related Receptor (ERR) Degradation,
Discovery of MD-224 as a First-in-Class, Highly Potent and Efficacious PROTAC MDM2 Degrader Capable of Achieving Complete and Durable Tumor Regression,
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

assay	95%
form	powder
storage temp.	2-8°C
SMILES string	O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCCCCCN)=O)NC1=O.Cl, O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCCCCCN)=O)NC1=O.Cl

pictograms	GHS08
signalword	Danger
hcodes	H360D
pcodes	P201 - P308 + P313
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable