(S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride 905402-50MG

Empirical Formula (Hill Notation):	C39H61ClN4O6S
CAS Number:	1835705-61-7
Molecular Weight:	749.44
MDL number:	MFCD31560481

Protein degrader builiding block (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl Chloride enables the synthesis of molecules for targeted protein degradation, and PROTAC (proteolysis-targeting chimeras) technology,. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks, with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL,
Targeted Protein Degradation by Small Molecules,
Small-Molecule PROTACS: New Approaches to Protein Degradation,
Targeted Protein Degradation: from Chemical Biology to Drug Discovery,
Impact of linker length on the activity of PROTACs,
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

assay	95%
form	solid
storage temp.	2-8°C
SMILES string	ClCCCCCCOCCCCCOCCCCCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O, ClCCCCCCOCCCCCOCCCCCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O

WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable