- Производитель:
- Sigma-Aldrich
NACRES: | NA.81 |
HPAd have been used in multiple studies investigating the cellular basis of diabetes and obesity, as well as mechanisms of action of various drug candidates. For example, it was shown that interaction between infiltrating monocytes and adipocytes affects production of metalloproteinases and osteopontin, a proinflammatory cytokine, which ultimately leads to development of more adipose tissue and insulin resistance (Samuvel, 2010, 2011). It was further demonstrated that adipocyte differentiation requires activation of Akt1 through the mTORC2-BSTA mechanism, leading to downstream suppression of FoxC2 (Yao, 2013).
Instead of protecting from hyperglycemia-induced ER stress, like it does in other cells, in adipocytes a bioactive, endogenously produced compound taurine was shown to modulate the expression of adipokines under inflammatory conditions by inhibiting the STAT-3 signaling pathway (Kim, 2013a,c), and to inhibit differentiation of preadipocytes into adipocytes (Kim, 2013b). Additionally, FGF21, which leads to reduction of body weight in animal models of obesity, was shown to act by modulating gene expression, phosphorylating Frs2a, Erk1/2, and Mypt1 (Muise, 2013) and by increasing oxidative capacity of adipocytes via AMPK–SIRT1–PGC1a cascade (Chau, 2010). Similarly, atrial natriuretic peptide (ANP) was shown to regulate lipid catabolism and reduce insulin resistance in HPAd by activating AMPK (Souza, 2011).
HPAd were also used to study adipocytokines in normal pregnancy and pregnancy-induced hypertension (Naruse, 2011), and to investigate the anti-obesity and hypolipidaemic properties of lotus seed extract (You, 2013, 2014). Finally, HPAd have been used to demonstrate the role of epigenetic modifications in increasing efficiency of iPS reprogramming (Rim, 2012).
- 2nd passage, >500,000 cells in Preadipocyte Cell Basal Medium that contains 20% FBS and 5% DMSO
- Can be cultured 2 passages before differentiation into Had
biological source | human adipose tissue (normal) |
Quality Level | 100, |
packaging | pkg of 500,000 cells (HMNC-BM) |
growth mode | Adherent |
karyotype | 2n = 46 |
morphology | Fibroblast-like |
application(s) | cell culture | mammalian: suitable |
relevant disease(s) | diabetes; obesity; obesity; cardiovascular diseases |
shipped in | dry ice |
storage temp. | −196°C |
RIDADR | NONH for all modes of transport |
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