N,N,N,N-Tetrakis(2-pyridylmethyl)ethylenediamine
Empirical Formula (Hill Notation): | C26H28N6 |
CAS Number: | 16858-02-9 |
Molecular Weight: | 424.54 |
Beilstein/REAXYS Number: | 4211982 |
MDL number: | MFCD00036918 |
PubChem Substance ID: | 24898538 |
NACRES: | NA.77 |
Кат. номер |
P4413-50MG |
P4413-100MG |
N,
N,
N,
N-Tetrakis(2-pyridylmethyl)ethylenediamine has been used:
- in the treatment of human embryonic kidney (HEK293T) cells for assessing its effect on the Jembrana disease virus (JDV) viral infectivity factor (Vif) functionality
- in P19 embryonic carcinoma cells for chelation of zinc ions released during apoptosis
- to evaluate its effect on lentiviral Vpx infection on human monocytic THP-1 cells
50, 100 mg in poly bottle
N,
N,
N,
N-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) elicits pro-apoptotic effect in human acute promyelocytic NB4 cells by inhibiting nitric oxide signalling and Zn2+ signaling. In microglia pretreated with zinc, TPEN inhibits the interleukin 6 secretion and nitric oxide synthase (iNOS) mRNA expression. It induces damage on DNA structure by activating ATM (ataxia telangiectasia mutated) and ATR (ATM-Rad3-related) signaling in human colon cancer cells.
TPEN is a membrane-permeable zinc chelator; decreased the intracellular level of zinc and induced apoptosis (i.e., cell shrinkage and formation of apoptotic bodies with DNA fragmentation and formation of a typical DNA ladder pattern).
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Quality Level | 100, |
SMILES string | C(CN(Cc1ccccn1)Cc2ccccn2)N(Cc3ccccn3)Cc4ccccn4 |
InChI | 1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2 |
Inchi Key | CVRXLMUYFMERMJ-UHFFFAOYSA-N |
Personal Protective Equipment | dust mask type N95 (US),, Eyeshields,, Gloves, |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point F | Not applicable |
Flash Point C | Not applicable |