Pharma & Biopharma Manufacturing
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Titriplex® III (ethylenedinitrilotetraacetic acid disodium salt dihydrate)
Empirical Formula (Hill Notation): C10H14N2Na2O8 · 2H2O CAS Number: 6381-92-6 Molecular Weight: 372.24 Beilstein/REAXYS Number: 3900609 EC Index Number: 205-358-3
Кат. номер 1084211000BWT CO1E1084219025 1084219028 1084212500 1084219336 1084211000 1.08421.1000DISC 1084219025 1084219500 1084210000 1084219025BWT CO1E1084211000 1.08421.9025.BWT 1.08421.1000.BWT 1.08421.9025 1.08421.1000 General descriptionFinding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.ApplicationTitriplex® III (EDTA, ethylene dinitrilo tetraacetic acid disodium salt dihydrate) is a commonly used chelating agent. As it is capable of forming complexes with divalent metal cations, it can inhibit diverse enzymes that require such cations for activity. It is broadly used as antioxidant in pharmaceutical formulations and cosmetics and can enhance the function of preservatives. The disodium salt provides improved solubility in water compared to standard EDTA.
Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.Other NotesElimination of water of crystallization: 110 °CLegal InformationEmprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
Titriplex is a registered trademark of Merck KGaA, Darmstadt, GermanyПараметрыstorage conditions no restrictions. Quality Level 500, Agency/Method BP, ChP, ISO 17025, JP, Ph. Eur., USP product line EMPROVE® ESSENTIAL form solid potency >2000 mg/kg LD50, oral (Rat) reaction suitability reaction type: Complexometric reactions application(s) titration: suitable pH 4-5 (20 °C, 50 g/L in H2O) mp 248 °C (dec.) (lit.) bulk density 700 kg/m3 storage temp. no temp limit SMILES string O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O InChI 1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2 InChI key OVBJJZOQPCKUOR-UHFFFAOYSA-L Узнать цену -
tri-Sodium citrate
Empirical Formula (Hill Notation): C6H5Na3O7 CAS Number: 68-04-2 Molecular Weight: 258.07 MDL number: MFCD00012462 E Number: E331 EC Index Number: 200-675-3
Кат. номер CO1E1110379026 1110371000 1110379026 1110379028 1110379026BWT CO1E1110371000 1110370000 1.11037.9026.BWT 1.11037.9026 1.11037.1000 General descriptionFinding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.Applicationtri-Sodium citrate anhydrous is typically used as a citrate buffer system component for biomolecule downstream chromatography steps or final liquid formulation.Legal InformationEmprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, GermanyПараметрыstorage conditions no restrictions. Quality Level 500, Agency/Method USP reg. compliance FCC product line EMPROVE® ESSENTIAL form fine powder potency >8000 mg/kg LD50, oral (Rat) pH 7.5-9.0 (20 °C, 10 g/L in H2O) mp 150 °C (decomposition) solubility 425 g/L density 1.76 g/cm3 at 18 °C bulk density 900 kg/m3 storage temp. 2-30°C InChI 1S/C6H8O7.3Na/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3 InChI key HRXKRNGNAMMEHJ-UHFFFAOYSA-K Узнать цену -
TRI-SODIUM CITRATE DIHYDRAT. CRYST.
Empirical Formula (Hill Notation): C6H5Na3O7 · 2H2O Linear Formula: HOC(COONa)(CH2COONa)2 · 2H2O CAS Number: 6132-04-3 Molecular Weight: 294.10 Beilstein/REAXYS Number: 6104939 MDL number: MFCD00150031 EC Index Number: 200-675-3
Кат. номер 1370429029 1370425000BWT 1370421000 1370429012 1370420001 1370420000 1370429999 1370425000 1.37042.5000 S1.37042.1000 1.37042.9012 1.37042.5000.BWT 1.37042.9029 US11370429028 General descriptionFinding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.Applicationtri-Sodium citrate dihydrate is typically used as a citrate buffer system component for biomolecule downstream chromatography steps or final liquid formulation.
Due to its low microbial and endotoxin limits, tri-Sodium citrate dihydrate cryst. Emprove® Expert is especially suitable for high-risk applications.Legal InformationEmprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, GermanyПараметрыstorage conditions Store at +5°C to +30°C. Quality Level 500, grade ACS reagent Agency/Method BP, JP, Ph. Eur., USP product line EMPROVE® EXPERT form crystalline powder potency >8000 mg/kg LD50, oral (Rat) pH 7.5-9.0 (25 °C, 50 g/L in H2O) mp 150 °C (anhydrous substance), >300 °C (lit.) bulk density 600 kg/m3 storage temp. 2-30°C SMILES string O.O.[Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O InChI 1S/C6H8O7.3Na.2H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;2*1H2/q;3*+1;;/p-3 InChI key NLJMYIDDQXHKNR-UHFFFAOYSA-K Узнать цену -
tri-Sodium citrate dihydrate
Empirical Formula (Hill Notation): C6H5Na3O7 · 2H2O Linear Formula: HOC(COONa)(CH2COONa)2 · 2H2O CAS Number: 6132-04-3 Molecular Weight: 294.10 Beilstein/REAXYS Number: 6104939 MDL number: MFCD00150031 E Number: E331 EC Index Number: 200-675-3
Кат. номер 1064469025 1064460000 1064469029BWT 1064461000 1064469029 1064469012 1064469999 1064469028 1.06446.9029 1.06446.1000 1.06446.9029.BWT General descriptionFinding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.Applicationtri-Sodium citrate dihydrate is typically used as a citrate buffer system component for biomolecule downstream chromatography steps or final liquid formulation.Legal InformationEmprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, GermanyПараметрыstorage conditions no restrictions. Quality Level 500, Agency/Method BP, JP, Ph. Eur., USP product line EMPROVE® ESSENTIAL form crystalline powder potency >8000 mg/kg LD50, oral (Rat) pH 7.5-9.0 (25 °C, 50 g/L in H2O) mp 150 °C (anhydrous substance), >300 °C (lit.) bulk density 600 kg/m3 storage temp. 2-30°C SMILES string O.O.[Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O InChI 1S/C6H8O7.3Na.2H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;2*1H2/q;3*+1;;/p-3 InChI key NLJMYIDDQXHKNR-UHFFFAOYSA-K Узнать цену -
TWEEN® 20
CAS Number: 9005-64-5 MDL number: MFCD00165986 NACRES: NA.25
Кат. номер T2700-100ML T2700-500ML T2700-1L General descriptionTWEEN® 20, also known as polysorbate 20, is a non-ionic detergent. It reduces the surface tension in solutions and thereby aids in uniform spreading of reagents. Tween 20 has a gentle action on cell lipids, preserves the integrity of cell surface antigens and aids in the staining of intracellular proteins.ApplicationTWEEN 20 has been used as a surfactant and has also been used for enzyme extraction.
Non-ionic detergent
Packaging
1 L in poly bottle
100, 500 mL in poly bottleLegal InformationTWEEN is a registered trademark of Croda International PLCПараметрыAgency/Method meets EP testing specifications Quality Level 200, description non-ionic form liquid mol wt ~1228 composition lauric acid, 40% (balance primarily myristic, palmoyic, and stearic acids) refractive index n20/D 1.468 (lit.) CMC 0.059 mM transition temp cloud point 76 °C density 1.095 g/mL at 25 °C (lit.) HLB 16.7 InChI 1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3 InChI key HMFKFHLTUCJZJO-UHFFFAOYSA-N
Safety InformationPersonal Protective Equipment Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F 527.0 °F - Pensky-Martens closed cup Flash Point C 275 °C - Pensky-Martens closed cup Узнать цену -
TWEEN® 60 (Polysorbate)
CAS Number: 9005-67-8 MDL number: MFCD01780110 EC Index Number: 500-020-4
Кат. номер 8170769050 CO1E8170769050 CO1E8170762500 8170762500 8170769999 8170760000 8.17076.2500 General descriptionFinding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.ApplicationPolysorbate 60 is used as surfactant in a variety of liquid formulations and acts e.g. as emulsifying, solubilizing and wetting agent.Legal InformationEmprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
TWEEN is a registered trademark of Croda International PLCПараметрыstorage conditions Store at +15°C to +25°C. Agency/Method JPE, NF, Ph. Eur. Quality Level 500, vapor pressure <10 hPa ( 20 °C) product line EMPROVE® ESSENTIAL potency >38000 mg/kg LD50, oral (Rat) pH 5.5-7.7 (25 °C, 50 g/L in H2O) kinematic viscosity 170-320 cSt(40 °C) transition temp flash point >149 °C density 1.1 g/cm3 at 20 °C storage temp. 15-25°C InChI 1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3 InChI key HMFKFHLTUCJZJO-UHFFFAOYSA-N Узнать цену -
Urea
Empirical Formula (Hill Notation): CH4N2O Linear Formula: NH2CONH2 CAS Number: 57-13-6 Molecular Weight: 60.06 Beilstein/REAXYS Number: 635724 MDL number: MFCD00008022 EC Index Number: 200-315-5
Кат. номер 1370309800 1370309012BWT 1370309526 1370300000 1370309012 1370305000 1370309026 1370309029 1370309150 1370309999 1370309100 1.37030.9012 1.37030.9012.BWT 1.37030.9029 1.37030.5000 General descriptionFinding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.ApplicationUrea is typically used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. It is useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. Urea may be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.
Due to its low microbial and endotoxin limits, Urea cryst. Emprove® Expert is especially suitable for high-risk applications.
Used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. Useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. May be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.Legal InformationEmprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, GermanyПараметрыstorage conditions Store at +15°C to +30°C. Quality Level 500, grade ACS reagent Agency/Method BP, JP, Ph. Eur., USP vapor pressure <0.1 hPa ( 20 °C) product line EMPROVE® EXPERT assay 98.0-102.0% (HPLC) potency 8471 mg/kg LD50, oral (Rat), 8200 mg/kg LD50, skin (Rat) pH 9 (20 °C, 100 g/L in H2O) mp 132-135 °C (lit.) density 1.335 g/mL at 25 °C (lit.) bulk density 720760 kg/m3 storage temp. 2-30°C SMILES string NC(N)=O InChI 1S/CH4N2O/c2-1(3)4/h(H4,2,3,4) InChI key XSQUKJJJFZCRTK-UHFFFAOYSA-N Узнать цену -
1-Thioglycerol
Empirical Formula (Hill Notation): C3H8O2S Linear Formula: HSCH2CH(OH)CH2OH CAS Number: 96-27-5 Molecular Weight: 108.16 Beilstein/REAXYS Number: 1732046 EC Number: 202-495-0 MDL number: MFCD00004879
Кат. номер 1087040500 1087040050 LinkageEmprove® Documentation,Legal InformationEmprove is a registered trademark of Merck KGaA, Darmstadt, GermanyПараметрыQuality Level 500, biological source synthetic Agency/Method NF description EMPROVE® ESSENTIAL form liquid packaging pkg of 500g (1087040500), pkg of 50g (1087040050) refractive index n20/D 1.527 (lit.) bp 118 °C/5 mmHg (lit.) density 1.25 g/mL at 25 °C (lit.) suitability suitable for manufacturing use SMILES string OCC(O)CS InChI 1S/C3H8O2S/c4-1-3(5)2-6/h3-6H,1-2H2 InChI key PJUIMOJAAPLTRJ-UHFFFAOYSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H302 - H311 - H315 - H317 pcodes P261 - P264 - P270 - P280 - P301 + P312 - P302 + P352 + P312 RIDADR UN 2810 6.1 / PGIII WGK Germany WGK 3 Узнать цену -
2-Mercaptoethanol
Empirical Formula (Hill Notation): C2H6OS Linear Formula: HSCH2CH2OH CAS Number: 60-24-2 Molecular Weight: 78.13 Beilstein/REAXYS Number: 773648 EC Number: 200-464-6 MDL number: MFCD00004890 PubChem Substance ID: 329748489 NACRES: NA.21
Кат. номер 7604-INTR 7604-1L 7604-100ML ApplicationBME is suitable for reducing protein disulfide bonds prior to polyacrylamide gel electrophoresis and is usually included in a sample buffer for SDS-PAGE at a concentration of 5%. Cleaving intermolecular (between subunits) disulfide bonds allows the subunits of a protein to separate independently on SDS-PAGE. Cleaving intramolecular (within subunit) disulfide bonds allows the subunits to become completely denatured so that each peptide migrates according to its chain length with no influence due to secondary structure.ПараметрыQuality Level 400, biological source synthetic vapor density 2.69 (vs air) vapor pressure 1 mmHg ( 20 °C) assay 99.0% (GC), 99.0-101.0% (iodometric, RT) form liquid expl. lim. 18 % concentration 14.3 M (pure liquid) refractive index n20/D 1.500 (lit.) bp 157 °C (lit.) solubility H2O: 1 mL/mL, clear, colorless density 1.114 g/mL at 25 °C (lit.) cation traces Cu: 1 mg/kg, Fe: 1 mg/kg, Ni: 1 mg/kg, Pb: 5 mg/kg, Zn: 1 mg/kg storage temp. 2-8°C SMILES string OCCS InChI 1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2 InChI key DGVVWUTYPXICAM-UHFFFAOYSA-N
Safety Informationpictograms GHS05,GHS06,GHS08,GHS09 signalword Danger hcodes H301 + H331 - H310 - H315 - H317 - H318 - H361d - H373 - H410 pcodes P273 - P280 - P301 + P310 - P302 + P352 + P310 - P304 + P340 + P311 - P305 + P351 + P338 RIDADR UN 2966 6.1 / PGII WGK Germany WGK 3 Flash Point F 165.2 °F - closed cup Flash Point C 74 °C - closed cup Узнать цену -
2-Mercaptoethanol 1371510100
Empirical Formula (Hill Notation): C2H6OS Linear Formula: HSCH2CH2OH CAS Number: 60-24-2 Molecular Weight: 78.13 Beilstein/REAXYS Number: 773648 MDL number: MFCD00004890 ApplicationBME is suitable for reducing protein disulfide bonds prior to polyacrylamide gel electrophoresis and is usually included in a sample buffer for SDS-PAGE at a concentration of 5%. Cleaving intermolecular (between subunits) disulfide bonds allows the subunits of a protein to separate independently on SDS-PAGE. Cleaving intramolecular (within subunit) disulfide bonds allows the subunits to become completely denatured so that each peptide migrates according to its chain length with no influence due to secondary structure.
Analysis Note
purity (GC) ≥99.0%Legal InformationEmprove is a registered trademark of Merck KGaA, Darmstadt, GermanyПараметрыQuality Level 400, vapor density 2.69 (vs air) vapor pressure 1 mmHg ( 20 °C) assay 99.0-101.0% (w/w) expl. lim. 18 % concentration 14.3 M (pure liquid) impurities 1.0% related substances (GC) 2,2-Dithiodiethanol refractive index n20/D 1.500 (lit.) bp 157 °C (lit.) density 1.114 g/mL at 25 °C (lit.) suitability corresponds for identity (IR) storage temp. 2-8°C SMILES string OCCS InChI 1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2 InChI key DGVVWUTYPXICAM-UHFFFAOYSA-N
Safety Informationpictograms GHS05,GHS06,GHS08,GHS09 signalword Danger hcodes H301 + H331 - H310 - H315 - H317 - H318 - H361fd - H373 - H410 pcodes P201 - P260 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P305 + P351 + P338 + P310 WGK Germany WGK 3 Flash Point F 165.2 °F - closed cup Flash Point C 74 °C - closed cup Узнать цену -
Betaine
Empirical Formula (Hill Notation): C5H11NO2 Linear Formula: (CH3)3N+CH2COO- CAS Number: 107-43-7 Molecular Weight: 117.15 Beilstein/REAXYS Number: 3537113 EC Number: 203-490-6 MDL number: MFCD00012123 PubChem Substance ID: 57651874 NACRES: NA.25
Кат. номер 61962-50G 61962-250G ApplicationBetaine has been used in reverse transcription to increase the thermal stability of proteins and to destabilize the DNA helix.Biochem/physiol ActionsBetaine has been shown to increase S-adenosylmethionine (SAM) levels and hence, may have a role in diminishing hepatic steatosis. It is an osmolyte which protects cells against environmental stress.
End-product of oxidative metabolism of choline, betaine is a general methyl donor, in particular in a minor pathway of methionine biosynthesis. It is used to treat homocystinuria, which is a defect in the major pathway of methionine biosynthesis.Параметрыproduct line BioUltra Quality Level 200 assay 99.0% (NT) impurities insoluble matters, passes filter test solubility methanol: 1 M at 20 °C, clear, colorless anion traces chloride (Cl-): 200 mg/kg, sulfate (SO42-): 200 mg/kg cation traces Ca: 10 mg/kg, Cd: 5 mg/kg, Co: 5 mg/kg, Cr: 5 mg/kg, Cu: 5 mg/kg, Fe: 5 mg/kg, K: 50 mg/kg, Mg: 5 mg/kg, Mn: 5 mg/kg, Na: 100 mg/kg, Ni: 5 mg/kg, Pb: 5 mg/kg, Zn: 5 mg/kg absorption 0.05 at 280 nm in methanol at 1 M, 0.08 at 260 nm in methanol at 1 M SMILES string C[N+](C)(C)CC([O-])=O InChI 1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 InChI key KWIUHFFTVRNATP-UHFFFAOYSA-N
Safety InformationPersonal Protective Equipment Eyeshields, Gloves, type N95 (US) RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
BIOTIN
Empirical Formula (Hill Notation): C10H16N2O3S CAS Number: 58-85-5 Molecular Weight: 244.31 Beilstein/REAXYS Number: 86838 EC Number: 200-399-3 MDL number: MFCD00005541 PubChem Substance ID: 329824251 NACRES: NA.21
Кат. номер RES1052B-B708X RES1052B-B707X RES1052B-B701X General descriptionTo request documentation for this product, please contact Customer Support, and select ‘Product Documentation. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.
Packaging
Product is available in the following package sizes:
RES1052B-B701X: 1 g container
RES1052B-B707X: 10 g container
RES1052B-B708X: 25 g containerПараметрыbiological source synthetic assay 97.5-100.5% form powder impurities Trace metals; tested color white mp 231-233 °C (lit.) suitability suitable for manufacturing use SMILES string [H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2 InChI 1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1 InChI key YBJHBAHKTGYVGT-ZKWXMUAHSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Cholesterol, Plant-Derived
Empirical Formula (Hill Notation): C27H46O CAS Number: 57-88-5 Molecular Weight: 386.65 Beilstein/REAXYS Number: 1915888 EC Number: 200-353-2 MDL number: MFCD00003646 PubChem Substance ID: 24892388
Кат. номер C1231-100G C1231-1G C1231-10G C1231-BR Biochem/physiol ActionsMajor component of all biological membranes; ~25% of total brain lipid is cholesterol.Preparation NoteSynthesized from material of non-animal originLegal InformationSyntheChol is a registered trademark of Sigma-Aldrich Co. LLCПараметрыQuality Level 500 biological source synthetic description SyntheChol® assay 98% bp 360 °C (lit.) mp 147-149 °C (lit.) density 1.067 g/mL at 25 °C (lit.) suitability suitable for manufacturing use shipped in dry ice storage temp. 20°C SMILES string CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C InChI 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 InChI key HVYWMOMLDIMFJA-DPAQBDIFSA-N Gene Information human ... POLA1(5422), TOP2A(7153)
rat ... Ar(24208), Polb(29240)
Safety InformationPersonal Protective Equipment Eyeshields, Gloves, type N95 (US) RIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Choline chloride
Empirical Formula (Hill Notation): C5H14ClNO Linear Formula: (CH3)3N(Cl)CH2CH2OH CAS Number: 67-48-1 Molecular Weight: 139.62 Beilstein/REAXYS Number: 3563126 EC Number: 200-655-4 MDL number: MFCD00011721 PubChem Substance ID: 329823030 NACRES: NA.21
Кат. номер PHG0021-10KG PHG0021-1KG PHG0021-100G PHG0021-5KG General descriptionTo request the documentation for this product, please contact Customer Support, and select ‘Product Documentation. Please note that access to documentation for this product requires a confidentiality disclosure agreement.
Packaging
100 g in poly bottle
1, 5, 10 kg in poly drum
Biochem/physiol Actions
The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .
Substrates
Choline acetyltransferase substrateПараметрыQuality Level 400, biological source synthetic form powder mol wt Mw 139.62 g/mol application(s) cell culture | mammalian: suitable impurities Endotoxin, microbial and lead, tested color white pH 5.0-6.5 (25 °C, 140 g/L) mp 302-305 °C (dec.) (lit.) solubility water: soluble 140 g/L suitability suitable for (manufacturing use) foreign activity foreign activity (Cytotoxicity; tested) SMILES string [Cl-].C[N+](C)(C)CCO InChI 1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1 InChI key SGMZJAMFUVOLNK-UHFFFAOYSA-M
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Cystamine dihydrochloride
Empirical Formula (Hill Notation): C4H12N2S2 · 2HCl Linear Formula: NH2CH2CH2SSCH2CH2NH2 · 2HCl CAS Number: 56-17-7 Molecular Weight: 225.20 Beilstein/REAXYS Number: 3616850 EC Number: 200-260-7 MDL number: MFCD00012905
Кат. номер 1083180750 1083180100 Legal InformationEmprove is a registered trademark of Merck KGaA, Darmstadt, GermanyПараметрыQuality Level 500, biological source synthetic Agency/Method non-compendial packaging pkg of Pkg of 100g (1083180100)
Pkg of 750g (1083180750)mp 217-220 °C (dec.) (lit.) SMILES string Cl[H].Cl[H].NCCSSCCN InChI 1S/C4H12N2S2.2ClH/c5-1-3-7-8-4-2-6;;/h1-6H2;2*1H InChI key YUFRRMZSSPQMOS-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 pcodes P264 - P270 - P301 + P312 - P501 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Dextran sulfate sodium salt
NACRES: NA.21
Кат. номер RES2029D-A707X RES2029D-A704X RES2029D-A702X RES2029D-A701X General descriptionTo request documentation for this product, please contact Customer Support, and select ‘Product Documentation. Please note that access to documentation for this product requires a confidentiality disclosure agreement.
Packaging
Product is available in the following package sizes:
RES2029D-A701X: 100 g container
RES2029D-A702X: 1 kg container
RES2029D-A707X: 10 g containerПараметрыQuality Level 400, biological source synthetic form powder optical activity []20/D 75 to 105 ° mol wt Mw 8000 g/mol application(s) cell culture | mammalian: suitable impurities Free Inorganic Sulfate; tested, Chloride; tested suitability suitable for manufacturing use
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 2 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Ferric ammonium citrate
Linear Formula: C6H8O7 ·xFe3+ · yNH3 CAS Number: 1185-57-5 EC Number: 214-686-6 NACRES: NA.21
Кат. номер RES20400-A703X RES20400-A702X General descriptionTo request documentation for this product, please contact Customer Support, and select ‘Product Documentation. Please note that access to documentation for this product requires a confidentiality disclosure agreement.
Packaging
Product is available in the following package sizes:
RES20400-A702X: 1 kg container
RES20400-A703X: 5 kg containerПараметрыbiological source synthetic form powder impurities Trace metals; tested suitability suitable for manufacturing use SMILES string N.OC12CC(=O)O[Fe](OC(=O)C1)OC(=O)C2 InChI 1S/C6H8O7.Fe.H3N/c7-3(8)1-6(13,5(11)12)2-4(9)10;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;1H3/q;+3;/p-3 InChI key FRHBOQMZUOWXQL-UHFFFAOYSA-K
Safety InformationRIDADR UN 3077 9 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Ferric citrate
Empirical Formula (Hill Notation): C6H5FeO7 · H2O CAS Number: 2338-05-8 Molecular Weight: 262.96 Beilstein/REAXYS Number: 4052503 EC Number: 219-045-4 MDL number: MFCD00013098 PubChem Substance ID: 329824271 NACRES: NA.21
Кат. номер RES4055F-A703X RES4055F-A702X General descriptionTo request documentation for this product, please contact Customer Support, and select ‘Product Documentation. Please note that access to documentation for this product requires a confidentiality disclosure agreement.
Packaging
Product is available in the following package sizes:
RES4055F-A702X: 1 kg container
RES4055F-A703X: 5 kg containerПараметрыbiological source synthetic form powder impurities Trace metals; tested suitability suitable for manufacturing use SMILES string OC12CC(=O)O[Fe](OC(=O)C1)OC2=O InChI 1S/C6H8O7.Fe/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3 InChI key NPFOYSMITVOQOS-UHFFFAOYSA-K
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Galactose, plant-derived
Empirical Formula (Hill Notation): C6H12O6 CAS Number: 59-23-4 Molecular Weight: 180.16 Beilstein/REAXYS Number: 1724619 MDL number: MFCD00151230
Кат. номер 1371290100 1371299010 1371291000 1371290000 1371299025 LinkageEmprove® Documentation,Legal InformationEmprove is a registered trademark of Merck KGaA, Darmstadt, GermanyПараметрыQuality Level 500, biological source plant Agency/Method NF, Ph. Eur. form powder packaging pkg of 100g (1371290100), pkg of 10kg (1371299010), pkg of 1kg (1371291000), pkg of 25kg (1371299025) mp 168-170 °C (lit.) SMILES string OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C=O InChI 1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h1,3-6,8-12H,2H2/t3-,4+,5+,6-/m0/s1 InChI key GZCGUPFRVQAUEE-KCDKBNATSA-N
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Glycine
Empirical Formula (Hill Notation): C2H5NO2 Linear Formula: NH2CH2COOH CAS Number: 56-40-6 Molecular Weight: 75.07 Beilstein/REAXYS Number: 635782 EC Number: 200-272-2 MDL number: MFCD00008131 eCl@ss: 32160406 PubChem Substance ID: 24895210 NACRES: NA.25
Кат. номер G5417-25KG G5417-1KG G5417-10KG G5417-100G General descriptionTo request the documentation for this product, please contact Customer Support and select ‘Product Documentation. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.ApplicationGlycine is a non-essential amino acid. It is the simplest of the amino acids and plays various roles in biology. It is structurally unique among the biological amino acids in that it does not have an asymmetric center, and thus is not chiral. It is commonly used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.Biochem/physiol ActionsInhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.Параметрыbiological source non-animal source assay 98.5% form crystalline powder Торговая марка Ajinomoto application(s) cell culture | mammalian: suitable impurities endotoxin, heavy metals, trace metals, residual solvents, tested pH 5.9-6.4 pKa (25 °C) (1) 2.35, (2) 9.60, 2.35 mp 240 °C (dec.) (lit.) solubility H2O: 100 mg/mL UV absorption : 260 nm Amax: 0.04, : 260 nm Amax: -0.006, : 280 nm Amax: 0.04, : 280 nm Amax: -0.003 suitability suitable for manufacturing use Featured Industry Pharmaceutical (small molecule) foreign activity cytotoxicity, tested SMILES string NCC(O)=O InChI 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) InChI key DHMQDGOQFOQNFH-UHFFFAOYSA-N Gene Information rat ... Grin2a(24409)
Safety InformationPersonal Protective Equipment Eyeshields, Gloves, type N95 (US) RIDADR NONH for all modes of transport WGK Germany WGK 1 Узнать цену -
GlycylGlycine G0674-100G
Empirical Formula (Hill Notation): C4H8N2O3 Linear Formula: NH2CH2CONHCH2COOH CAS Number: 556-50-3 Molecular Weight: 132.12 Beilstein/REAXYS Number: 1765223 EC Number: 209-127-8 MDL number: MFCD00008130 PubChem Substance ID: 329799819 NACRES: NA.21 ApplicationGlycylglycine is the dipeptide of glycine and one of the simplest peptides. It also works as a buffering agent.
Packaging
100 g in poly bottleПараметрыQuality Level 500, biological source synthetic form powder impurities heavy metals, tested useful pH range 7.5 - 8.9 pKa (25 °C) 8.2 suitability suitable for manufacturing use SMILES string NCC(=O)NCC(O)=O InChI 1S/C4H8N2O3/c5-1-3(7)6-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9) InChI key YMAWOPBAYDPSLA-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Hypoxanthine, monosodium salt
Empirical Formula (Hill Notation): C5H3N4O · Na Molecular Weight: 158.09 NACRES: NA.21
PackagingКат. номер RES6104H-A701X RES6104H-A702X
Product is available in the following package sizes:
RES6104H-A701X: 100g container
RES6104H-A702X: 1kg containerПараметрыQuality Level 400, biological source synthetic form powder application(s) cell culture | mammalian: suitable impurities Endotoxin and microbial, tested suitability suitable for manufacturing use foreign activity Cytotoxicity, DNase, NICKase, RNase, and Protease; tested
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Iodoacetamide
Empirical Formula (Hill Notation): C2H4INO Linear Formula: ICH2CONH2 CAS Number: 144-48-9 Molecular Weight: 184.96 Beilstein/REAXYS Number: 1739080 EC Number: 205-630-1 MDL number: MFCD00008028 PubChem Substance ID: 329815381 NACRES: NA.21
PackagingКат. номер I5161-25G I5161-100G
25, 100 g in glass bottleApplicationAlkylating reagent for cysteine residues in peptide sequencing. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibition of ribonuclease.ПараметрыQuality Level 400, biological source synthetic assay 99% (NMR) form powder mp 92-95 °C (lit.) solubility H2O: 0.5 M, clear, colorless suitability suitable for manufacturing use storage temp. 2-8°C SMILES string NC(=O)CI InChI 1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5) InChI key PGLTVOMIXTUURA-UHFFFAOYSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 - H315 - H317 - H319 - H335 pcodes P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Узнать цену -
Isopropyl -D-1-thiogalactopyranoside
Empirical Formula (Hill Notation): C9H18O5S CAS Number: 367-93-1 Molecular Weight: 238.30 Beilstein/REAXYS Number: 4631 EC Number: 206-703-0 MDL number: MFCD00063273 PubChem Substance ID: 329823027
Кат. номер PHG0010-1000G-PW PHG0010-100G-PW PHG0010-25G-PW PHG0010-5G PHG0010-1000G PHG0010-100G PHG0010-25G PHG0010-5G-PW ApplicationIPTG is commonly used in cloning procedures that require induction of -galactosidase activity. It is used in conjunction with X-Gal or Bluo-Gal in blue-white selection of recombinant bacterial colonies that induce expression of the lac operon in Escherichia coli. IPTG functions by binding to the lacI repressor and altering its conformation, which prevents the repression of the -galactosidase coding gene lacZ.Other NotesNon-metabolizable galactose analog.ПараметрыQuality Level 300 biological source synthetic storage temp. 2-8°C SMILES string CC(C)S[C@@H]1OC(CO)[C@H](O)C(O)[C@H]1O InChI 1S/C9H18O5S/c1-4(2)15-9-8(13)7(12)6(11)5(3-10)14-9/h4-13H,3H2,1-2H3/t5-,6+,7+,8-,9+/m1/s1 InChI key BPHPUYQFMNQIOC-NXRLNHOXSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
L-Arginine
Empirical Formula (Hill Notation): C6H14N4O2 Linear Formula: H2NC(=NH)NH(CH2)3CH(NH2)CO2H CAS Number: 74-79-3 Molecular Weight: 174.20 Beilstein/REAXYS Number: 1725413 EC Number: 200-811-1 MDL number: MFCD00002635 eCl@ss: 32160406 PubChem Substance ID: 57653850 NACRES: NA.26
Кат. номер A4474-100G A4474-25KG A4474-1KG A4474-10KG General descriptionTo request documentation for this product, please contact Customer Support and select ‘Product Documentation. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.ApplicationL-Arginine is a non-essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.Biochem/physiol ActionsSubstrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.Параметрыbiological source non-animal source assay >98.5% form crystalline powder Торговая марка Ajinomoto application(s) cell culture | mammalian: suitable impurities endotoxin, heavy metals, trace metals, residual solvents, tested mp 222 °C (dec.) (lit.) solubility H2O: 100 mg/mL suitability suitable for manufacturing use Featured Industry Pharmaceutical (small molecule) SMILES string N[C@@H](CCCNC(N)=N)C(O)=O InChI 1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1 InChI key ODKSFYDXXFIFQN-BYPYZUCNSA-N Gene Information human ... NOS1(4842), NOS2(4843)
rat ... Ppm1a(24666)
Safety InformationPersonal Protective Equipment Eyeshields, Gloves, type N95 (US) RIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
L-Arginine monohydrochloride
Empirical Formula (Hill Notation): C6H14N4O2 · HCl CAS Number: 1119-34-2 Molecular Weight: 210.66 Beilstein/REAXYS Number: 3631658 EC Number: 214-275-1 MDL number: MFCD00064550 PubChem Substance ID: 57653852 NACRES: NA.26
Кат. номер A4599-100G A4599-10KG A4599-A150XCONF A4599-25KG A4599-A150X A4599-1KG General descriptionTo request documentation for this product, please contact Customer Support and select ‘Product Documentation. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.ApplicationL-Arginine is a non-essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. L-Arginine monohydrochloride is a modified version of L-Arginine with improved solubility.Biochem/physiol ActionsSubstrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.Параметрыbiological source non-animal source assay 98.5% form crystalline powder Торговая марка Ajinomoto application(s) cell culture | mammalian: suitable impurities endotoxin, heavy metals, residual solvents, tested solubility H2O: 100 mg/mL density 1.42 g/cm3 at 20 °C anion traces chloride (Cl-): 16.58-17.00%, sulfate (SO42-): 0.020% cation traces As: 1.0 ppm, NH4+: 0.02%, heavy metals: 10 ppm Featured Industry Pharmaceutical (small molecule) foreign activity cytotoxicity, tested SMILES string Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O InChI 1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1 InChI key KWTQSFXGGICVPE-WCCKRBBISA-N
Safety InformationPersonal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves RIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
L-Asparagine monohydrate
Empirical Formula (Hill Notation): C4H8N2O3 · H2O Linear Formula: NH2COCH2CH(NH2)COOH · H2O CAS Number: 5794-13-8 Molecular Weight: 150.13 Beilstein/REAXYS Number: 1723527 EC Number: 200-735-9 MDL number: MFCD00151038 PubChem Substance ID: 329824249 NACRES: NA.21
Кат. номер RES10070-A702X RES10070-A704X RES10070-A701X ApplicationL-Asparagine is an essential amino acid. It is used as a cell culture media component and raw material for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.
Packaging
Product is available in the following package sizes:
RES10070-A701X: 100g container
RES10070-A702X: 1kg container
RES10070-A704X: 10kg containerПараметрыQuality Level 400, biological source synthetic assay 98.5-101.0% dry basis form powder application(s) cell culture | mammalian: suitable impurities endotoxin and microbial, tested mp 233-235 °C (lit.) suitability suitable for manufacturing use foreign activity Cytotoxicity, DNase, NICKase, RNase, and Protease; tested SMILES string [H]O[H].N[C@@H](CC(N)=O)C(O)=O InChI 1S/C4H8N2O3.H2O/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H2,6,7)(H,8,9);1H2/t2-;/m0./s1 InChI key RBMGJIZCEWRQES-DKWTVANSSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
L-Cysteine
Empirical Formula (Hill Notation): C3H7NO2S Linear Formula: HSCH2CH(NH2)CO2H CAS Number: 52-90-4 Molecular Weight: 121.16 Beilstein/REAXYS Number: 1721408 EC Number: 200-158-2 MDL number: MFCD00064306 eCl@ss: 32160406 PubChem Substance ID: 24892777 NACRES: NA.26
Кат. номер C5360-100G C5360-25KG C5360-1KG C5360-10KG General descriptionTo request documentation for this product, please contact Customer Support and select ‘Product Documentation. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.ApplicationL-Cysteine is a non-essential amino acid. It is commonly used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.Biochem/physiol ActionsNMDA glutamatergic receptor agonist.Параметрыbiological source non-animal source form crystalline powder Торговая марка Ajinomoto application(s) cell culture | mammalian: suitable impurities endotoxin, heavy metals, trace metals, tested mp 240 °C (dec.) (lit.) solubility H2O: 25 mg/mL suitability suitable for manufacturing use foreign activity cytotoxicity, tested SMILES string N[C@@H](CS)C(O)=O InChI 1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 InChI key XUJNEKJLAYXESH-REOHCLBHSA-N
Safety InformationPersonal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves RIDADR NONH for all modes of transport WGK Germany WGK 1 Узнать цену -
L-Cysteine S-sulfate sodium salt sesquihydrate
Empirical Formula (Hill Notation): C3H6NNaO5S2 · 1.5H2O CAS Number: 150465-29-5 Molecular Weight: 250.23
Кат. номер 1371160100 1371165000 1371161000 137116-INTR 1371160001 General descriptionModified amino acids are inhouse manufactured amino acid derivatives with specific properties enabling the intensification of cell culture processes.
Together with the companion product Phospho-L-Tyrosine disodium Salt disodium salt, the new modified amino acid S-Sulfocysteine sodium salt can be used as replacement for cysteine to generate highly concentrated, neutral pH feeds. Both modified amino acids eliminate the need for alkaline feeds, which are normally applied to ensure solubility and stability of the unmodified amino acids tyrosine and cysteine.
Features and Benefits- Reduced complexity in fed-batch process
- High concentrations of modified cysteine in main feeds at neutral pH
- Prevention of caustic shocks in the bioreactor due to high pH feeds
- More convenient preparation process with less contamination risks
- Reduction of recombinant protein fragmentation and decrease in trisulfide bond content
- Higher feed stability at room temperature
LinkageWebinar
Title: Simplification of Fed-Batch Processes Using Modified Amino Acids,Legal InformationEmprove is a registered trademark of Merck KGaA, Darmstadt, GermanyПараметрыstorage conditions Store at +15°C to +25°C. Quality Level 500, biological source synthetic product line EMPROVE® EXPERT form powder or crystals packaging pkg of 1 kg (1371161000), pkg of 100 g (1371160100), pkg of 5 kg (1371165000) solubility water: soluble (Up to 1.3M (room temp)) suitability suitable for manufacturing use (cell culture media) storage temp. room temp
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
L-Cystine
Empirical Formula (Hill Notation): C6H12N2O4S2 Linear Formula: [-SCH2CH(NH2)CO2H]2 CAS Number: 56-89-3 Molecular Weight: 240.30 Beilstein/REAXYS Number: 1728094 EC Number: 200-296-3 MDL number: MFCD00064228 PubChem Substance ID: 24892581 NACRES: NA.26
Кат. номер C5735-100G C5735-25KG C5735-10KG C5735-1KG Параметрыbiological source non-animal source assay 98.5% Торговая марка Ajinomoto application(s) cell culture | mammalian: suitable impurities endotoxin, tested mp >240 °C (dec.) (lit.) solubility 1 M HCl: 100 mg/mL suitability suitable for manufacturing use Featured Industry Pharmaceutical (small molecule) SMILES string N[C@@H](CSSC[C@H](N)C(O)=O)C(O)=O InChI 1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1 InChI key LEVWYRKDKASIDU-IMJSIDKUSA-N
Safety InformationPersonal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
L-Cystine dihydrochloride, non-animal derived
Empirical Formula (Hill Notation): C6H12N2O4S2 · 2HCl CAS Number: 30925-07-6 Molecular Weight: 313.22 EC Number: 250-391-9 MDL number: MFCD00070399 PubChem Substance ID: 329824260 NACRES: NA.21
Кат. номер RES1513C-A701X RES1513C-A702X RES1513C-A704X ApplicationL-Cystine is a sulfur containing non-essential amino acid. It is used as a cell culture media component and raw material in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. L-Cystine dihydrochloride is a modified version of L-Cystine with improved solubility.
Packaging
This product is available in the following package sizes:
RES1513C-A701X: 100g container
RES1513C-A704X: 10kg containerПараметрыQuality Level 400, biological source synthetic description Non-Animal Derived form powder application(s) cell culture | mammalian: suitable impurities endotoxin, microbial, and trace metals, tested suitability suitable for manufacturing use foreign activity Cytotoxicity, DNase, NICKase, RNase, and Protease; tested SMILES string Cl.Cl.N[C@@H](CSSC[C@H](N)C(O)=O)C(O)=O InChI 1S/C6H12N2O4S2.2ClH/c7-3(5(9)10)1-13-14-2-4(8)6(11)12;;/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12);2*1H/t3-,4-;;/m0../s1 InChI key HHGZUQPEIHGQST-RGVONZFCSA-N
Safety Informationpictograms GHS05 signalword Danger hcodes H314 pcodes P260 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 RIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
L-Glutamic acid, monosodium salt, Low Endotoxin
Empirical Formula (Hill Notation): C5H8NNaO4 Linear Formula: NaOOCCH2CH2CH(NH2)COOH CAS Number: 142-47-2 Molecular Weight: 169.11 EC Number: 205-538-1 PubChem Substance ID: 329824272 NACRES: NA.21
Кат. номер RES5063G-A701X RES5063G-A702X RES5063G-A705X RES5063G-A704X ApplicationL-Glutamic acid is a non-essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.
Packaging
Product is available in the following package sizes:
RES5063G-A701X: 100g container
RES5063G-A702X: 1kg container
RES5063G-A704X: 10kg container
RES5063G-A705X: 25kg containerПараметрыQuality Level 400, biological source synthetic form powder application(s) cell culture | mammalian: suitable impurities endotoxin and microbial, tested suitability suitable for manufacturing use foreign activity Cytotoxicity, DNase, NICKase, RNase, and Protease; tested
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 2 Узнать цену -
L-Glutamine
Empirical Formula (Hill Notation): C5H10N2O3 Linear Formula: H2NCOCH2CH2CH(NH2)CO2H CAS Number: 56-85-9 Molecular Weight: 146.14 Beilstein/REAXYS Number: 1723797 EC Number: 200-292-1 MDL number: MFCD00008044 eCl@ss: 32160406 PubChem Substance ID: 24895232 NACRES: NA.26
Кат. номер G5792-100G G5792-25KG G5792-1KG G5792-10KG General descriptionTo request documentation for this product, please contact Customer Support and select ‘Product Documentation. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.ApplicationL-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-Glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-Glutamine prior to use.Biochem/physiol ActionsL-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.Параметрыbiological source non-animal source assay 99% form powder Торговая марка Ajinomoto application(s) cell culture | mammalian: suitable impurities endotoxin, heavy metals, residual solvents, tested mp 185 °C (dec.) (lit.) solubility H2O: 25 mg/mL Featured Industry Pharmaceutical (small molecule) foreign activity cytotoxicity, tested SMILES string N[C@@H](CCC(N)=O)C(O)=O InChI 1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 InChI key ZDXPYRJPNDTMRX-VKHMYHEASA-N Gene Information rat ... Ggt1(116568)
Safety InformationPersonal Protective Equipment Eyeshields, Gloves, type N95 (US) RIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
L-Histidine
Empirical Formula (Hill Notation): C6H9N3O2 CAS Number: 71-00-1 Molecular Weight: 155.15 Beilstein/REAXYS Number: 84088 EC Number: 200-745-3 MDL number: MFCD00064315 eCl@ss: 32160406 PubChem Substance ID: 57654248 NACRES: NA.26
Кат. номер H3911-100G H3911-10KG H3911-A150XCONF H3911-25KG H3911-A150X H3911-1KG General descriptionTo request documentation for this product, please contact Customer Support and select ‘Product Documentation. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.ApplicationL-Histitidine is an essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.Biochem/physiol ActionsPrecursor of histamine by action of histidine decarboxylase.Параметрыbiological source non-animal source assay 98.5% form crystalline powder Торговая марка Ajinomoto application(s) cell culture | mammalian: suitable impurities endotoxin, heavy metals, trace metals, residual solvents, tested mp 282 °C (dec.) (lit.) solubility H2O: 50 mg/mL suitability suitable for manufacturing use Featured Industry Pharmaceutical (small molecule) foreign activity cytotoxicity, tested SMILES string N[C@@H](Cc1c[nH]cn1)C(O)=O InChI 1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 InChI key HNDVDQJCIGZPNO-YFKPBYRVSA-N Gene Information human ... CA1(759), CA2(760)
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L-Histidine monohydrochloride monohydrate
Empirical Formula (Hill Notation): C6H9N3O2 · HCl · H2O CAS Number: 5934-29-2 Molecular Weight: 209.63 Beilstein/REAXYS Number: 4168261 MDL number: MFCD00151027 eCl@ss: 32160406 PubChem Substance ID: 57654249 NACRES: NA.26
Кат. номер H4036-100G H4036-10KG H4036-A150XCONF H4036-25KG H4036-A150X H4036-1KG General descriptionTo request documentation for this product, please contact Customer Support and select ‘Product Documentation. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.ApplicationL-Histidine, an essential amino acid. It is used as a cell culture media component in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. L-Histidine monohydrochloride monohydrate is a modified version of L-Histidine with improved solubility.Параметрыbiological source non-animal source assay 98.5% form powder Торговая марка Ajinomoto application(s) cell culture | mammalian: suitable impurities endotoxin, heavy metals, residual solvents, tested mp 254 °C (dec.) (lit.) solubility H2O: 50 mg/mL Featured Industry Pharmaceutical (small molecule) foreign activity cytotoxicity, tested SMILES string O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O InChI 1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1 InChI key CMXXUDSWGMGYLZ-XRIGFGBMSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H319 pcodes P264 - P280 - P305 + P351 + P338 - P337 + P313 Personal Protective Equipment Eyeshields, Gloves, type N95 (US) RIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
L-Isoleucine
Empirical Formula (Hill Notation): C6H13NO2 Linear Formula: C2H5CH(CH3)CH(NH2)CO2H CAS Number: 73-32-5 Molecular Weight: 131.17 Beilstein/REAXYS Number: 1721792 EC Number: 200-798-2 MDL number: MFCD00064222 eCl@ss: 32160406 PubChem Substance ID: 57654304 NACRES: NA.26
Кат. номер I5281-100G I5281-25KG I5281-1KG I5281-10KG General descriptionTo request documentation for this product, please contact Customer Support, and select ‘Product Documentation. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.ApplicationL-Isoleucine is an essential amino acid. It can be biosynthesized from threonine or through fermentation of carbohydrates. The amino acid L-isoleucine is an isomer of L-Leucine, differing in the position of the side chain. It is also considered to be a branched chain amino acid, along with L-Leucine and L-Valine, which are sources of fuel and/or transport during cell development. It is used as a cell culture media component in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.Параметрыbiological source non-animal source assay 98.5% form crystalline powder Торговая марка Ajinomoto application(s) cell culture | mammalian: suitable impurities endotoxin, heavy metals, residual solvents, tested mp 288 °C (dec.) (lit.) solubility 1 M HCl: 50 mg/mL Featured Industry Pharmaceutical (small molecule) foreign activity cytotoxicity, tested SMILES string CC[C@H](C)[C@H](N)C(O)=O InChI 1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 InChI key AGPKZVBTJJNPAG-WHFBIAKZSA-N
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L-Methionine
Empirical Formula (Hill Notation): C5H11NO2S Linear Formula: CH3SCH2CH2CH(NH2)CO2H CAS Number: 63-68-3 Molecular Weight: 149.21 Beilstein/REAXYS Number: 1722294 EC Number: 200-562-9 MDL number: MFCD00063097 eCl@ss: 32160406 PubChem Substance ID: 57654418 NACRES: NA.26
Кат. номер M8439-100G M8439-25KG M8439-1KG M8439-10KG General descriptionTo request documentation for this product, please contact Customer Support and select ‘Product Documentation. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.ApplicationL-Methionine is an essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.Параметрыbiological source non-animal source assay 99% form powder Торговая марка Ajinomoto application(s) cell culture | mammalian: suitable impurities endotoxin, heavy metals, trace metals, residual solvents, tested mp 284 °C (dec.) (lit.) solubility H2O: 50 mg/mL suitability suitable for manufacturing use Featured Industry Pharmaceutical (small molecule) foreign activity cytotoxicity, tested SMILES string CSCC[C@H](N)C(O)=O InChI 1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 InChI key FFEARJCKVFRZRR-BYPYZUCNSA-N Gene Information rat ... Ggt1(116568)
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L-Methionine sulfoximine
Empirical Formula (Hill Notation): C5H12N2O3S Linear Formula: CH3S(O)(=NH)CH2CH2CH(NH2)CO2H CAS Number: 15985-39-4 Molecular Weight: 180.23 Beilstein/REAXYS Number: 6175446 MDL number: MFCD00002621
Кат. номер 1043090001 1043090010 1043090005 LinkageEmprove® DocumentationLegal InformationEmprove is a registered trademark of Merck KGaA, Darmstadt, GermanyПараметрыQuality Level 500 product line EMPROVE® ESSENTIAL form solid packaging pkg of 10g (1043090010), pkg of 1g (1043090001), pkg of 5g (1043090005), pkg of mp >210 °C (dec.) (lit.) suitability suitable for manufacturing use SMILES string CS(=N)(=O)CC[C@H](N)C(O)=O InChI 1S/C5H12N2O3S/c1-11(7,10)3-2-4(6)5(8)9/h4,7H,2-3,6H2,1H3,(H,8,9)/t4-,11?/m0/s1 InChI key SXTAYKAGBXMACB-DPVSGNNYSA-N
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L-Proline
Empirical Formula (Hill Notation): C5H9NO2 CAS Number: 147-85-3 Molecular Weight: 115.13 Beilstein/REAXYS Number: 80810 EC Number: 205-702-2 MDL number: MFCD00064318 PubChem Substance ID: 57654568 NACRES: NA.26
Кат. номер P8865-100G P8865-25KG P8865-1KG P8865-10KG General descriptionTo request documentation for this product, please contact Customer Support and select ‘Product Documentation. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.ApplicationL-Proline is a non-essential amino acid. Peptides bond to Proline, making it a useful building block for proteins. It can be used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.Параметрыbiological source non-animal source assay 98.5% form crystalline powder Торговая марка Ajinomoto application(s) cell culture | mammalian: suitable impurities endotoxin, heavy metals, residual solvents, tested mp 228 °C (dec.) (lit.) solubility H2O: 50 mg/mL Featured Industry Pharmaceutical (small molecule) foreign activity cytotoxicity, tested SMILES string OC(=O)[C@@H]1CCCN1 InChI 1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 InChI key ONIBWKKTOPOVIA-BYPYZUCNSA-N
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L-Serine
CAS Number: 56-45-1 Molecular Weight: 105.09 MDL number: MFCD00064224 EC Index Number: 200-274-3
Кат. номер 1076479010 1076470000 1076471000 1.07647.1000 General descriptionFinding the right chemical that matches your pharma and biopharma manufacturing needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for pharma and biopharma manufacturing withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
Analysis Note
Assay (perchloric acid titration, calculated on dried substance)98.5 - 101.0 %Identity (IR-spectrum)passes testIdentity (specific rotation)passes testAppearancewhite to almost white or colorless, needle-shaped crystalsAppearance of solution (50 g/l; water)clear and not more intense in color than reference solution BYSpec. rotation ( 20/D, 100g/l, hydrochloric acid 2mol/l, calc. on dried substance)+14.0 to +16.0Spec. rotation ( 25/D, 100g/l, hydrochloric acid 2mol/l, calc. on dried substance)+14.0 to +15.6Chloride (Cl) 200 ppmSulfate (SO) 300 ppmCo (Cobalt) 0.5 ppmCu(Copper) 25 ppmFe (Iron) 10 ppmMn (Manganese) 25 ppmMo (Molybdenum) 2.5 ppmZn (Zinc) 130 ppmRelated Compounds, total (TLC) 0.5 %Ninhydrin-positive substances (LC)(any ninhydrin-positive impurity) 0.2 %Ninhydrin-positive substances (LC) (ammonium (570 nm)) 0.02 %Ninhydrin-positive substances (LC)(total impurities) 0.5 %Methanol (HS-GC) 3000 ppmOther residual solvents (ICH Q3C)excluded by manufacturing processSulfated ash (600°C) 0.1 %Loss on drying (105 °C; 3h) 0.2 %Bacterial endotoxins 2.0 I.U./gTotal aerobic microbial count (TAMC) 100 CFU/gTotal combined yeasts/moulds count (TYMC) 100 CFU/gElemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).Corresponds to Ph.Eur., USP.Other NotesDue to its low microbial and endotoxin limits, L-Serine Emprove® Expert is suitable for biopharma manufacturing needs.Legal InformationEmprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, GermanyПараметрыstorage conditions Store at +5°C to +30°C. Quality Level 500, Agency/Method JP, Ph. Eur., USP product line EMPROVE® EXPERT form crystalline powder pH 5-6 (20 °C, 100 g/L in H2O) mp 215-225 °C (decomposes) solubility 360 g/L bulk density 570 kg/m3 storage temp. 2-30°C InChI 1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7) InChI key MTCFGRXMJLQNBG-UHFFFAOYSA-N Узнать цену -
L-Threonine
Empirical Formula (Hill Notation): C4H9NO3 Linear Formula: CH3CH(OH)CH(NH2)CO2H CAS Number: 72-19-5 Molecular Weight: 119.12 Beilstein/REAXYS Number: 1721646 EC Number: 200-774-1 MDL number: MFCD00064270 PubChem Substance ID: 57654668 NACRES: NA.26
Кат. номер T4071-10KG T4071-25KG T4071-1KG T4071-100G General descriptionTo request documentation for this product, please contact Customer Support, and select ‘Product Documentation. Please note that access to documentation for this product requires a confidentiality disclosure agreement.ApplicationL-Threonine is a β-hydroxy-α-amino acid. It is an essential amino acid and can be used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.Параметрыbiological source non-animal source assay 98.5% form crystalline powder Торговая марка Ajinomoto application(s) cell culture | mammalian: suitable impurities endotoxin, heavy metals, trace metals, residual solvents, tested mp 256 °C (dec.) (lit.) solubility H2O: 50 mg/mL suitability suitable for manufacturing use foreign activity cytotoxicity, tested SMILES string C[C@@H](O)[C@H](N)C(O)=O InChI 1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 InChI key AYFVYJQAPQTCCC-GBXIJSLDSA-N
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L-Tyrosine
Empirical Formula (Hill Notation): C9H11NO3 Linear Formula: 4-(HO)C6H4CH2CH(NH2)CO2H CAS Number: 60-18-4 Molecular Weight: 181.19 Beilstein/REAXYS Number: 392441 EC Number: 200-460-4 MDL number: MFCD00002606 eCl@ss: 32160406 PubChem Substance ID: 57654670
Кат. номер T4321-10KG T4321-25KG T4321-1KG T4321-100G General descriptionTo request documentation for this product, please contact Customer Support, and select ‘Product Documentation. Please note that access to documentation for this product requires a confidentiality disclosure agreement.ApplicationL-Tyrosine is a non-essential amino acid with a polar side group. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.Other NotesAmino acid precursor of dopamine and other catecholaminesПараметрыbiological source non-animal source assay 99% form crystalline powder Торговая марка Ajinomoto application(s) cell culture | mammalian: suitable impurities endotoxin, heavy metals, trace metals, residual solvents, tested mp >300 °C (dec.) (lit.) solubility 1 M HCl: 25 mg/mL Featured Industry Pharmaceutical (small molecule) foreign activity cytotoxicity, tested SMILES string N[C@@H](Cc1ccc(O)cc1)C(O)=O InChI 1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 InChI key OUYCCCASQSFEME-QMMMGPOBSA-N
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L-Tyrosine disodium salt dihydrate
CAS Number: 122666-87-9 NACRES: NA.21
Кат. номер RES3156T-A702X RES3156T-A703X RES3156T-A704X RES3156T-A701X ApplicationTyrosine is a polar, naturally occurring, non-essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.
Packaging
Product is available in the following package sizes:
RES3156T-A701X: 100g container
RES3156T-A702X 1kg container
RES3156T-A704X: 10kg containerПараметрыQuality Level 400, biological source synthetic form powder application(s) cell culture | mammalian: suitable impurities endotoxin, microbial, and heavy metals, tested suitability suitable for manufacturing use foreign activity Cytotoxicity, DNase, NICKase, RNase, and Protease; tested
Safety Informationpictograms GHS05 signalword Danger hcodes H318 pcodes P280 - P305 + P351 + P338 + P310 RIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
L-Valine
Empirical Formula (Hill Notation): C5H11NO2 Linear Formula: (CH3)2CHCH(NH2)CO2H CAS Number: 72-18-4 Molecular Weight: 117.15 Beilstein/REAXYS Number: 1721136 EC Number: 200-773-6 MDL number: MFCD00064220 PubChem Substance ID: 57654728 NACRES: NA.26
Кат. номер V4638-10KG V4638-25KG V4638-1KG V4638-100G General descriptionTo request documentation for this product, please contact Customer Support, and select ‘Product Documentation. Please note that access to documentation for this product requires a confidentiality disclosure agreement.ApplicationL-Valine is a branched-chain essential amino acid. It can be used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.Параметрыbiological source non-animal source assay 98.5% form powder Торговая марка Ajinomoto application(s) cell culture | mammalian: suitable impurities endotoxin, heavy metals, trace metals, residual solvents, tested mp 295-300 °C (subl.) (lit.) solubility H2O: 25 mg/mL suitability suitable for manufacturing use Featured Industry Pharmaceutical (small molecule) foreign activity cytotoxicity, tested storage temp. 20-25°C SMILES string CC(C)[C@H](N)C(O)=O InChI 1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 InChI key KZSNJWFQEVHDMF-BYPYZUCNSA-N
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Linoleic acid
Empirical Formula (Hill Notation): C18H32O2 Linear Formula: CH3(CH2)4CH=CHCH2CH=CH(CH2)7CO2H CAS Number: 60-33-3 Molecular Weight: 280.45 Beilstein/REAXYS Number: 1727101 EC Number: 200-470-9 MDL number: MFCD00064241 PubChem Substance ID: 329755832
Кат. номер 39269-INTR 39269-VAR 39269-1KG 39269-10G 39269-100G General descriptionTo request documentation for this product, please contact Customer Support, and select ‘Product Documentation. Please note that access to documentation for this product requires a confidentiality disclosure agreement.
Biochem/physiol Actions
Linoleic acid increases cell proliferation and gene expression of PPARα and its target genes such as acyl-CoA oxidase in primary duck hepatocytes .
Analysis Note
microbiol contamination 1000 CFU/g
residual solvents (GLC-HS) conforms ICHQ3ПараметрыQuality Level 400, assay 98.0% (GC) form liquid application(s) cell culture | mammalian: suitable impurities heavy metals, tested refractive index n20/D 1.466 (lit.) bp 229-230 °C/16 mmHg (lit.) mp 5 °C (lit.) density 0.902 g/mL at 25 °C (lit.) storage temp. 2-8°C SMILES string OC(CCCCCCC/C=C\C/C=C\CCCCC)=O InChI 1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9- InChI key OYHQOLUKZRVURQ-HZJYTTRNSA-N
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Methotrexate
Empirical Formula (Hill Notation): C20H22N8O5 CAS Number: 59-05-2 Molecular Weight: 454.44 Beilstein/REAXYS Number: 70669 EC Number: 200-413-8 MDL number: MFCD00064370 PubChem Substance ID: 329817917 NACRES: NA.21
Кат. номер M7824-5G M7824-1G Параметрыbiological source synthetic Quality Level 400 form powder suitability suitable for manufacturing use storage temp. −20°C SMILES string CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O InChI 1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1 InChI key FBOZXECLQNJBKD-ZDUSSCGKSA-N Gene Information human ... DHFR(1719)
Safety Informationpictograms GHS06,GHS08 signalword Danger hcodes H301 - H315 - H319 - H341 - H360D pcodes P201 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 RIDADR UN 1544PSN1 6.1 / PGIII WGK Germany WGK 3 Узнать цену -
N-Acetyl-D-mannosamine
Empirical Formula (Hill Notation): C8H15NO6 CAS Number: 7772-94-3 Molecular Weight: 221.21
Кат. номер PHG0017-100G PHG0017-1KG PHG0017-10G Параметрыapplication(s) cell culture | mammalian: suitable Quality Level 400 shipped in wet ice storage temp. 20°C SMILES string CC(=O)N[C@@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O InChI 1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5+,6-,7-,8+/m1/s1 InChI key OVRNDRQMDRJTHS-UOLFYFMNSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Oleic acid
Empirical Formula (Hill Notation): C18H34O2 Linear Formula: CH3(CH2)7CH=CH(CH2)7COOH CAS Number: 112-80-1 Molecular Weight: 282.46 Beilstein/REAXYS Number: 1726542 EC Number: 204-007-1 MDL number: MFCD00064242
Кат. номер 91541-INTR 91541-100G 91541-10G 91541-VAR General descriptionTo request documentation for this product, please contact Customer Support, and select ‘Product Documentation. Please note that access to documentation for this product requires a confidentiality disclosure agreement.
Biochem/physiol Actions
Uncouples oxidative phosphorylation. Inhibits 2,4-dinitrophenol−stimulated ATPase. Action reversed by adding serum albumin.
Activates protein kinase C in hepatocytes.
Analysis Note
remarks on GC: content of fatty acid pass
pharmacopoea tests: mineral acid pass
microbiol contamination 1000 CFU/g
residual solvents (GLC-HS) conforms to ICH Q3ПараметрыQuality Level 400, vapor pressure 1 mmHg ( 176 °C) assay 98.0% (w/w) (GC), 99.0% (GC) application(s) cell culture | mammalian: suitable impurities 0.4% water ign. residue 0.01% refractive index n20/D 1.459 (lit.) bp 194-195 °C/1.2 mmHg (lit.) mp 13-14 °C (lit.) acid value 190205 KOH/g iodine value 85105 peroxide value 10.0 transition temp freezing point 10-16 °C density 0.889-0.895 g/mL at 20 °C, 0.89 g/mL at 25 °C (lit.) cation traces As: 2 mg/kg, heavy metals: 20 mg/kg storage temp. 2-8°C SMILES string CCCCCCCC\C=C/CCCCCCCC(O)=O InChI 1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9- InChI key ZQPPMHVWECSIRJ-KTKRTIGZSA-N
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