Pfizer® Compounds
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UK-383,367
Empirical Formula (Hill Notation): C15H24N4O4 CAS Number: 348622-88-8 Molecular Weight: 324.38 MDL number: MFCD19690945 PubChem Substance ID: 329823739 NACRES: NA.77
Кат. номер PZ0156-5MG PZ0156-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
UK-383,367 is a procollagen C-proteinase (PCP) inhibitor.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Cytoskeleton & Extracellular Matrix research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder optical activity []/D 15°, c = 0.5 in methanol Торговая марка Pfizer® color white to off-white solubility DMSO: >30 mg/mL originator Pfizer storage temp. room temp SMILES string NC(=O)c1noc(n1)[C@H](CCCC2CCCCC2)CC(=O)NO InChI 1S/C15H24N4O4/c16-13(21)14-17-15(23-19-14)11(9-12(20)18-22)8-4-7-10-5-2-1-3-6-10/h10-11,22H,1-9H2,(H2,16,21)(H,18,20)/t11-/m1/s1 InChI key ARJCBSRIPGJMAD-LLVKDONJSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P301 + P310 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
UK-5099
Empirical Formula (Hill Notation): C18H12N2O2 CAS Number: 56396-35-1 Molecular Weight: 288.30 MDL number: MFCD19443867 PubChem Substance ID: 329823742 NACRES: NA.77
Кат. номер PZ0160-5MG PZ0160-25MG ApplicationUK-5099 has been used:- as a mitochondrial pyruvate blocker to reduce pyruvate transportation into mitochondria in Roswell park memorial institute (RPMI) 1640 medium for prostatic cancer cell line culture
- in dimethyl sulfoxide (DMSO) stock, to study the effect of inhibiting pyruvate transport into mitochondria on pro-inflammatory responses in lipopolysaccharide activated macrophages
- in topical treatment in order to study its effect on hair cycle induction in experimental mice
Packaging5, 25 mg in glass bottleBiochem/physiol ActionsUK-5099 induces lactate generation.
UK-5099 is a potent inhibitor of the mitochondrial pyruvate transporter. In rat heart mitochondria, UK-5099 inhibits pyruvate-dependent O2 consumption with an IC50 of 50 nM.Features and BenefitsThis compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.Other NotesThis compound was developed by Pfizer for Apoptosis & Cell Cycle research. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100 assay 98% (HPLC) form powder Торговая марка Pfizer® color yellow to tan solubility DMSO: >20 mg/mL originator Pfizer storage temp. 2-8°C SMILES string OC(=O)\C(=C\c1cn(-c2ccccc2)c3ccccc13)C#N InChI 1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+ InChI key BIZNHCWFGNKBBZ-JLHYYAGUSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
UK-59811 hydrochloride
Empirical Formula (Hill Notation): C22H29BrN2O5 · HCl Molecular Weight: 517.84 NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0353-25MG PZ0353-5MG
UK-59811 is a 1,4-dihydropyridine calcium channel blocker. It has been used in a crystallographic and functional analysis of drug binding to the bacterial homotetrameric model voltage-gated calcium channel CaVAb, comparing 1,4-dihydropyridine binding to phenylalkylamine binding. UK-59811 inhibited CaVAb with an IC50 value of 194 nM, binding at the outer, lipid-facing surface of the pore at the interface between two CaVAb subunits, while at concentrations above 1 μM, it also bound in the pore. It was contrasted with phenylalkylamine Br-verapamil which binds on the intracellular side of the selectivity filter in the central cavity of the pore, physically blocking the pore.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. 2-8°C SMILES string CCOC(C1=C(COCCN(C)C)NC(C)=C(C(OC)=O)C1C2=C(Br)C=CC=C2)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Узнать цену -
UK-78282 monohydrochloride
Empirical Formula (Hill Notation): C29H35NO2HCl CAS Number: 136647-02-4 Molecular Weight: 466.05 MDL number: MFCD16875438 PubChem Substance ID: 329827628 NACRES: NA.77
Кат. номер U3885-5MG U3885-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desired, as there are few if any currently available. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function.
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.
This compound is featured on the Potassium Channels, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
Preparation Note
UK-78282 monohydrochloride dissolves in DMSO at a concentration >10 mg/ml.ПараметрыQuality Level 100, assay ≥98% (HPLC) form solid storage condition desiccated color white to off-white solubility DMSO: >10 mg/mL originator Pfizer shipped in wet ice storage temp. −20°C SMILES string Cl.COc1ccc(CCCN2CCC(CC2)COC(c3ccccc3)c4ccccc4)cc1 InChI 1S/C29H35NO2.ClH/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27;/h2-7,10-17,25,29H,8-9,18-23H2,1H3;1H InChI key ZZSQARULZYQMIG-UHFFFAOYSA-N
Safety Informationpictograms GHS07,GHS09 signalword Warning hcodes H319 - H400 pcodes P273 - P305 + P351 + P338 RIDADR UN 3077 9 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Valdecoxib
Empirical Formula (Hill Notation): C16H14N2O3S CAS Number: 181695-72-7 Molecular Weight: 314.36 MDL number: MFCD00950568 PubChem Substance ID: 329823753 NACRES: NA.77
Кат. номер PZ0179-25MG PZ0179-5MG General descriptionValdecoxib (VCX) is a diaryl substituted isoxazole compound. It comprises of sulfonyl propanamide and is a metabolite of parecoxib.ApplicationValdecoxib may be used: as cyclooxygenase-2 (COX-2) inhibitor in fibroblast cells, as an analyte for mass spectrometry analysis, as an standard in ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for quantification of valdecoxib in plasma samples
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Valdecoxib is reported to elicit anti-inflammatory, analgesic and antipyretic functionality. It acts as a substrate for the liver enzyme cytochrome P450 2C9(CYP2C9) and cytochrome P450 3A4 (CYP3A4).
Valdecoxib is a non-steroidal anti-inflammatory drug (NSAID), a cyclooxygenase-2 (COX-2) selective inhibitor.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Lipid Signaling research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to off-white solubility DMSO: >25 mg/mL originator Pfizer storage temp. room temp SMILES string Cc1onc(-c2ccccc2)c1-c3ccc(cc3)S(N)(=O)=O InChI 1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20) InChI key LNPDTQAFDNKSHK-UHFFFAOYSA-N Gene Information human ... PTGS2(5743)
Safety Informationpictograms GHS08,GHS09 signalword Warning hcodes H361d - H373 - H410 pcodes P201 - P202 - P260 - P273 - P280 - P308 + P313 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Varenicline tartrate
Empirical Formula (Hill Notation): C13H13N3 · C4H6O6 CAS Number: 375815-87-5 Molecular Weight: 361.35 MDL number: MFCD08460603 PubChem Substance ID: 329823673 NACRES: NA.77
Кат. номер PZ0004-5MG PZ0004-25MG ApplicationVarenicline tartrate has been used to investigate its effect on sensorimotor gating in rats under prepulse inhibition (PPI). It is suitable for use as a reference standard in capillary isotachophoresis (ITP) coupled on-line with capillary zone electrophoresis (CZE) for the quantification of varenicline metabolite in urine samples. It is also suitable for use for testing its effect on locomotor and nonlocomotor behavioral deficits in rats.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Varenicline tartrate is a partial α4β2 nicotinic receptor agonist and α7 full agonist. Varenicline competitively binds to α4β2 receptors and partially stimulates without creating a full nicotine effect, while simultaneoudly blocking the ability of nicotine to bind to the receptors. Varenicline thus blocks the ability of nicotine to activate α4β2 receptors and stimulate the central nervous mesolimbic dopamine system, believed to be the neuronal mechanism underlying reinforcement and reward experienced upon smoking.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is a featured product for ADME Tox research. Click here, to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.
This compound is featured on the Acetylcholine Receptors (Nicotinic), page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: >5 mg/mL originator Pfizer storage temp. room temp SMILES string O[C@H]([C@@H](O)C(O)=O)C(O)=O.C1NC[C@H]2C[C@@H]1c3cc4nccnc4cc23 InChI 1S/C13H13N3.C4H6O6/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1;5-1(3(7)8)2(6)4(9)10/h1-2,4-5,8-9,14H,3,6-7H2;1-2,5-6H,(H,7,8)(H,9,10)/t8-,9+;1-,2-/m.1/s1 InChI key TWYFGYXQSYOKLK-CYUSMAIQSA-N
Safety Informationpictograms GHS07,GHS09 signalword Warning hcodes H302 - H400 pcodes P264 - P270 - P273 - P301 + P312 - P391 - P501 RIDADR UN 3077 9 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Voriconazole
Empirical Formula (Hill Notation): C16H14F3N5O CAS Number: 137234-62-9 Molecular Weight: 349.31 MDL number: MFCD00905717 PubChem Substance ID: 329823674 NACRES: NA.77
Кат. номер PZ0005-5MG PZ0005-25MG General descriptionVoriconazole is a triazole and a synthetic derivative of fluconazole.ApplicationVoriconazole has been used:- as a control and Erg11 inhibitor in YPD medium
- as a reference drug to test the activity of essential oils against clinical strains of Candida sp.
- as an antifungal agent to test its interactions with valproic acid (VPA)
- to compare its in vitro antifungal activity with essential oils and its components against Cryptococcus neoformans azole-susceptible and not-susceptible clinical isolates
Packaging5 mg in glass bottle
25 mg in poly bottleBiochem/physiol ActionsVoriconazole is used to treat invasive aspergillosis (IA). It is vigorous against Candida species, including the strains of Candida albicans, which shows resistance to fluconazole.
Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.Features and BenefitsThis compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.Other NotesThis compound was developed by Pfizer for Immunology research. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100 assay 98% (HPLC) form white powder Торговая марка Pfizer® solubility DMSO: >20 mg/mL originator Pfizer storage temp. room temp SMILES string C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F InChI 1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1 InChI key BCEHBSKCWLPMDN-MGPLVRAMSA-N
Safety Informationpictograms GHS06,GHS08 signalword Danger hcodes H301 - H341 - H351 - H361 - H371 - H372 - H373 - H412 pcodes P201 - P202 - P260 - P264 - P273 - P301 + P310 Target Organs Eyes RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
WAY 170523
Empirical Formula (Hill Notation): C33H31N3O7S CAS Number: 307002-73-9 Molecular Weight: 613.68 MDL number: MFCD09753279 PubChem Substance ID: 329823839 NACRES: NA.77
Кат. номер PZ0322-5MG PZ0322-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
WAY 170523 is a potent and selective inhibitor of matrix metalloprotease MMP-13 (Collagenase-3), expressed in the skeleton during embryonic development, and sometimes highly overexpressed in human carcinomas and in chondrocytes and synovial cells in rheumatoid arthritis and osteoarthritis. Mutations in the MMP-13 gene has been shown to cause metaphyseal anadysplasia (MANDP). WAY 170523 has an IC50 of 17 nM for MMP-13 and showed >5800-, 56-, and >500-fold selectivity against MMP-1, MMP-9, and TACE (TNF converting enzyme), respectively.Other NotesThis compound was developed by Pfizer for Cytoskeleton & Extracellular Matrix research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 25 mg/mL, clear originator Pfizer storage temp. room temp SMILES string O=S(N(CC1=CC=CC=C1)C2=C(C(NO)=O)C=C(C)C=C2C)(C3=CC=C(OCCNC(C4=CC5=C(C=CC=C5)O4)=O)C=C3)=O InChI 1S/C33H31N3O7S/c1-22-18-23(2)31(28(19-22)32(37)35-39)36(21-24-8-4-3-5-9-24)44(40,41)27-14-12-26(13-15-27)42-17-16-34-33(38)30-20-25-10-6-7-11-29(25)43-30/h3-15,18-20,39H,16-17,21H2,1-2H3,(H,34,38)(H,35,37) InChI key FARMEEAGJWMFSZ-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Узнать цену -
WAY-208466 dihydrochloride
Empirical Formula (Hill Notation): C17H18FN3O2S · 2HCl CAS Number: 1207064-61-6 Molecular Weight: 420.33 MDL number: MFCD28384460 PubChem Substance ID: 329823827 NACRES: NA.77
Кат. номер PZ0305-5MG PZ0305-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
WAY-208466 is a high affinity (Ki = 4.8 nM) 5-HT6 receptor agonist. In HeLa cells expressing cloned human 5-HT6, the compound induced cAMP production (EC50 = 7.3 nM; Emax = 100%). WAY-208466 increases cortical GABA levels and exhibits anxiolytic activity in rat studies.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility H2O: 5 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string CN(C)CCN1C=C(S(C2=CC=CC(F)=C2)(=O)=O)C3=CC=CN=C31 InChI 1S/C17H18FN3O2S/c1-20(2)9-10-21-12-16(15-7-4-8-19-17(15)21)24(22,23)14-6-3-5-13(18)11-14/h3-8,11-12H,9-10H2,1-2H3 InChI key SFSFIDVAEMDPIP-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
WAY-252623
Empirical Formula (Hill Notation): C21H12ClF5N2 CAS Number: 875787-07-8 Molecular Weight: 422.78
Кат. номер PZ0257-5MG PZ0257-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
WAY-252623 (LXR623) is an orally available, potent and highly selective Liver X receptors (LXRs) agonist that significantly reduced total and LDL-cholesterol. WAY-252623 reduces lesion progression in the murine LDLR(-/-) atherosclerosis model.Other NotesThis compound was developed by Pfizer for Lipid Signaling research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P301 + P310 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
WAY-362450
Empirical Formula (Hill Notation): C25H24F2N2O3 CAS Number: 629664-81-9 Molecular Weight: 438.47 MDL number: MFCD13181507 PubChem Substance ID: 329823801
Кат. номер PZ0267-5MG PZ0267-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
WAY-362450 is a potent and selective Farnesoid X receptor (FXR) agonist that lowers total plasma cholesterol (all lipoprotein species). WAY-362450 reduced the levels of high-density lipoprotein cholesterol (HDLc) in Cynomolgus monkeys, mice and hamsters. Apparently HDL lowering is achieved through increased transhepatic cholesterol efflux.Other NotesThis compound was developed by Pfizer for Gene Regulation research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string FC1=C(F)C=C(C(N2CC(C)(C)C(C(C=CC=C3)=C3N4)=C4C(C(OC(C)C)=O)=C2)=O)C=C1 InChI 1S/C25H24F2N2O3/c1-14(2)32-24(31)17-12-29(23(30)15-9-10-18(26)19(27)11-15)13-25(3,4)21-16-7-5-6-8-20(16)28-22(17)21/h5-12,14,28H,13H2,1-4H3 InChI key INASOKQDNHHMRE-UHFFFAOYSA-N Gene Information human ... NR1H4(9971)
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
WYE-125132
Empirical Formula (Hill Notation): C27H33N7O4 CAS Number: 1144068-46-1 Molecular Weight: 519.60
Кат. номер PZ0321-5MG PZ0321-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
WYE-125132 (WYE-132) is a highly potent, ATP-competitive, and specific inhibitor of mTOR with an IC50 value of 0.19 nM. Unlike rapamycin, which ihibits mTOR through allosteric binding to mTOR complex 1 (mTORC1) only, WYE-132 inhibits both mTORC1 and mTORC2. WYE-125132 is >5000-fold selective for mTOR vs. phosphoinositide 3-kinase (PI3K). WYE-132 induced apoptosis in a variety of cancer lines including LNCap prostate cells and H1975 lung cancer cells. WYE-132 also inhibited ovarian cancer cell growth.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 97% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. 20°C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Узнать цену -
Zoniporide hydrochloride hydrate
Empirical Formula (Hill Notation): C17H16N6O · xHCl · yH2O CAS Number: 241800-98-6 Molecular Weight: 320.35 (anhydrous free base basis) MDL number: MFCD04113213 PubChem Substance ID: 329825138 NACRES: NA.77
Кат. номер SML0076-IP SML0076-50MG SML0076-10MG ApplicationZoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models. It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication.
Zoniporide hydrochloride hydrate may be used in Na+/H+-mediated cell signaling studies.
Packaging
10, 50 mg in glass bottle
Biochem/physiol Actions
Zoniporide is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1). IC50 = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na+ update with IC50 of 14 nM.
Zoniporide, a selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE-1) has cardioprotective effects against myocardial injuries and ischemic insults. It inhibits the swelling human platelets and attenuates cardiac contractile dysfunction in rats. Zoniporide might have neurotoxic effects as it causes peripheral sensory axonopathy.
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.ПараметрыQuality Level 100, assay 98% (HPLC) form powder color white to tan solubility H2O: 2 mg/mL, clear (warmed) originator Pfizer storage temp. 2-8°C SMILES string O.Cl.NC(=N)NC(=O)c1cnn(-c2cccc3ncccc23)c1C4CC4 InChI 1S/C17H16N6O.ClH.H2O/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H;1H2 InChI key UCIJUEGJEFJRMP-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Zopolrestat
Empirical Formula (Hill Notation): C19H12F3N3O3S CAS Number: 110703-94-1 Molecular Weight: 419.38 MDL number: MFCD00865476 PubChem Substance ID: 329831615 NACRES: NA.77
Кат. номер Z4527-50MG Z4527-10MG
Packaging
10, 50 mg in glass bottle
Biochem/physiol Actions
Zopolrestat is an inhibitor of Aldose Reductase. AR family members AKR1B1 and AKR1B10 have additionally been shown to play roles in inflammation and cancer.
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.
This compound is featured on the Dopamine and Norepinephrine Metabolism, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.Legal InformationPfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color off-white to light brown solubility DMSO: 20 mg/mL originator Pfizer storage temp. 2-8°C SMILES string OC(=O)CC1=NN(Cc2nc3cc(ccc3s2)C(F)(F)F)C(=O)c4ccccc14 InChI 1S/C19H12F3N3O3S/c20-19(21,22)10-5-6-15-14(7-10)23-16(29-15)9-25-18(28)12-4-2-1-3-11(12)13(24-25)8-17(26)27/h1-7H,8-9H2,(H,26,27) InChI key BCSVCWVQNOXFGL-UHFFFAOYSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 - H413 pcodes P273 - P301 + P310 + P330 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену
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