Empirical Formula (Hill Notation): | C15H17N3O2 |
CAS Number: | 478149-53-0 |
Molecular Weight: | 271.31 |
PubChem Substance ID: | 329823720 |
NACRES: | NA.77 |
Кат. номер |
PZ0135-5MG |
PZ0135-25MG |
PHA-543613 has been used to study its effect on recognition memory and neurovascular coupling (NVC) response in β-amyloid (Aβ) 25-35-treated mice. It has also been used to study its effect on Aβ25-35-induced receptor alteration and cognitive impairment in mice.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PHA-543613 exhibits rapid brain penetration property.
PHA-543613 is a potent selective 7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression in brain. The homomeric subtype 7 is a potential therapeutic target for cognitive deficits in schizophrenia and Alzheimers disease. PHA-543613 is active in both
in vitro (binding, calcium flux, patch-clamp) and
in vivo (auditory gating, novel object recognition) assays.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the Acetylcholine Receptors (Nicotinic), page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
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This compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
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Quality Level | 100, |
assay | 98% (HPLC) |
form | powder |
Торговая марка | Pfizer® |
color | white to off-white |
solubility | DMSO: 20 mg/mL |
originator | Pfizer |
storage temp. | room temp |
SMILES string | O=C(N[C@H]1CN2CC[C@H]1CC2)c3cc4ccoc4cn3 |
InChI | 1S/C15H17N3O2/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19)/t13-/m0/s1 |
InChI key | IPKZCLGGYKRDES-ZDUSSCGKSA-N |
Gene Information | human ... CHRNA7(1139) |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 1 |
Flash Point F | Not applicable |
Flash Point C | Not applicable |