Pfizer® Compounds
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PF-06465469
Empirical Formula (Hill Notation): C30H33N7O2 CAS Number: 1407966-77-1 Molecular Weight: 523.63 NACRES: NA.77
Кат. номер PZ0209-5MG PZ0209-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06465469 is a potent, covalent inhibitor of the nonreceptor tyrosine kinase Itk (IL-2 inducible T-cell kinase), which is expressed primarily in immune cells, and is strongly upregulated following activation of T-cells. PF-06465469 inhibits Itk enzymatic activity with an IC50 of 2 nM. The compound blocks anti-CD3 induced phosphorylation of PLCg in Jurkat cells (IC50 = 31 nM) and IL-2 production in anti-CD3 stimulated human whole blood (IC50 = 48 nM).
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here, to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 97% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear originator Pfizer storage temp. 2-8°C
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06649283
Empirical Formula (Hill Notation): C18H19F2N3O2S CAS Number: 1621585-17-8 Molecular Weight: 379.42 MDL number: MFCD28580118 PubChem Substance ID: 329823797 NACRES: NA.77
PackagingКат. номер PZ0261-5MG PZ0261-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06649283 is a new β-Secretase (BACE) inhibitor.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear originator Pfizer storage temp. 2-8°C SMILES string C[C@@H]1[C@@]2([H])[C@@](CO[C@@H](C3=CC(C)=NO3)C2)(C4=CC=C(F)C=C4F)N=C(N)S1 InChI 1S/C18H19F2N3O2S/c1-9-5-16(25-23-9)15-7-13-10(2)26-17(21)22-18(13,8-24-15)12-4-3-11(19)6-14(12)20/h3-6,10,13,15H,7-8H2,1-2H3,(H2,21,22)/t10-,13+,15-,18-/m1/s1 InChI key HVEVDFRWOQHAPJ-CKMNQQOVSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P280 - P305 + P351 + P338 - P337 + P313 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06651385
Empirical Formula (Hill Notation): C16H11ClF3N3O4S2 Molecular Weight: 465.85 NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0381-5MG PZ0381-25MG
PF-06651385 is an Nav1.3 voltage-gated sodium channel modulator.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. room temp SMILES string ClC1=CC(COC2=CC=C(S(NC3=NC=NS3)(=O)=O)C=C2)=CC=C1OC(F)(F)F
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06651481-00
Empirical Formula (Hill Notation): C26H29Cl2N5O3 CAS Number: 1391063-17-4 Molecular Weight: 530.45 MDL number: MFCD22418831 PubChem Substance ID: 329823815
PackagingКат. номер PZ0289-5MG PZ0289-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06651481-00 is an isomer of orally available dual Src/Abl kinase inhibitor Bosutinib.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string CN(CC1)CCN1CCCOC2=C(OC)C=C3C(N=CC(C#N)=C3NC4=CC(Cl)=C(OC)C(Cl)=C4)=C2 InChI 1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-24-14-22-19(13-23(24)34-2)25(17(15-29)16-30-22)31-18-11-20(27)26(35-3)21(28)12-18/h11-14,16H,4-10H2,1-3H3,(H,30,31) InChI key YCLIWTLPTXAGPQ-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06651600
Empirical Formula (Hill Notation): C15H19N5O · C3H4O4 CAS Number: 1792180-81-4 Molecular Weight: 389.41 PubChem Substance ID: 329823834
PackagingКат. номер PZ0316-5MG PZ0316-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06651600 is a potent and selective JAK3 inhibitor.
PF-06651600 specifically targets the ATP (adenosine triphosphate)-binding domain of JAK3 (Janus kinase 3). Loss of function of JAK3 is associated with severe combined immunodeficiency syndrome.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility H2O: 5 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string C[C@@H]1N(C(C=C)=O)C[C@H](NC2=NC=NC3=C2C=CN3)CC1.OC(CC(O)=O)=O InChI 1S/C15H19N5O.C3H4O4/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15;4-2(5)1-3(6)7/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19);1H2,(H,4,5)(H,6,7)/t10-,11+;/m0./s1 InChI key QMPMPSGDPRHZCG-VZXYPILPSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06658607
Empirical Formula (Hill Notation): C27H24N6O2 CAS Number: 1621002-24-1 Molecular Weight: 464.52 NACRES: NA.77
Кат. номер PZ0242-5MG PZ0242-25MG ApplicationPF-06658607 has been used to evaluate the proteome-wide selectivity of covalent kinase inhibitors.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06658607 is an alkynylated irreversible Brutons tyrosine kinase (BTK) inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-06658607 has been used as a probe for proteomic analysis to identify off-target binding substrates. The alkyne moiety allows for addition of an azide-based detection probe via copper-catalyzed click chemistry methods.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06663181-00
Empirical Formula (Hill Notation): C26H29Cl2N5O3 Molecular Weight: 530.45 MDL number: MFCD29037207 PubChem Substance ID: 329823816
PackagingКат. номер PZ0290-25MG PZ0290-5MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06663181-00 is an isomer of orally available dual Src/Abl kinase inhibitor Bosutinib.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to light brown solubility DMSO: 10 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CN(CC1)CCN1CCCOC2=C(OC)C=C3C(N=CC(C#N)=C3NC4=C(Cl)C(OC)=CC=C4Cl)=C2 InChI 1S/C26H29Cl2N5O3/c1-32-8-10-33(11-9-32)7-4-12-36-23-14-20-18(13-22(23)35-3)25(17(15-29)16-30-20)31-26-19(27)5-6-21(34-2)24(26)28/h5-6,13-14,16H,4,7-12H2,1-3H3,(H,30,31) InChI key FQJJFZPWUDJHKM-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06663195
Empirical Formula (Hill Notation): C18H18F3N3O2S CAS Number: 1621585-22-5 Molecular Weight: 397.41 MDL number: MFCD28580119 PubChem Substance ID: 329823798 NACRES: NA.77
PackagingКат. номер PZ0262-5MG PZ0262-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06663195 is a potent inhibitor of β-site amyloid precursor protein (APP) Cleaving Enzyme 1 (BACE1, β-Secretase 1).Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string [H][C@@]12[C@@](CO[C@@H](C3=CC(C)=NO3)C2)(C4=CC=C(F)C=C4F)N=C(N)S[C@@H]1CF InChI 1S/C18H18F3N3O2S/c1-9-4-15(26-24-9)14-6-12-16(7-19)27-17(22)23-18(12,8-25-14)11-3-2-10(20)5-13(11)21/h2-5,12,14,16H,6-8H2,1H3,(H2,22,23)/t12-,14+,16+,18+/m0/s1 InChI key JIAYOIBUKDISBO-IYPIGGPWSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P280 - P305 + P351 + P338 - P337 + P313 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06663829-00
Empirical Formula (Hill Notation): C26H29Cl2N5O3 Molecular Weight: 530.45 PubChem Substance ID: 329823814 NACRES: NA.77
PackagingКат. номер PZ0288-5MG PZ0288-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06663829-00 is an analog of orally available dual Src/Abl kinase inhibitor Bosutinib.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to light brown solubility DMSO: 5 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string N#CC1=C(NC2=CC(Cl)=C(Cl)C(OC)=C2)C3=CC(OC)=C(OCCCN4CCN(C)CC4)C=C3N=C1 InChI 1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-23-14-21-19(13-22(23)34-2)26(17(15-29)16-30-21)31-18-11-20(27)25(28)24(12-18)35-3/h11-14,16H,4-10H2,1-3H3,(H,30,31) InChI key PQVSLWANEOVWPO-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06672131
Empirical Formula (Hill Notation): C23H21ClFN5O2 CAS Number: 1621002-27-4 Molecular Weight: 453.90 MDL number: MFCD28386021 PubChem Substance ID: 329823789
Кат. номер PZ0243-5MG PZ0243-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06672131 is a selective EGFR kinase inhibitor thought to covalently react with active-site cysteine residues in the ATP binding pocket. PF-06672131 has been used as a probe for proteomic analysis to identify off-target binding substrates. The dimethylaminomethyl (DMAM) group appears to increase compound stability in cancer cells with a resultant increase in protein reactivity from selective EGFR binding to widespread proteome-wide reactivity after treatment.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 95% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OCC#C)=C(NC(/C=C/CN(C)C)=O)C=C32
Safety Informationpictograms GHS07 signalword Warning hcodes H302 - H315 - H319 - H335 pcodes P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06700841 tosylate salt PZ0345-5MG
Empirical Formula (Hill Notation): C18H21F2N7O · C7H8O3S CAS Number: 1883299-62-4 Molecular Weight: 561.60 PubChem Substance ID: 329823853 ApplicationPF-06700841 tosylate salt has been used as an inhibitor of Janus kinase1 (JAK1) to study its therapeutic effect on the adjuvant induced arthritis (AIA) rat model. It has also been used as an inhibitor of interferon-α/β receptor alpha chain (IFNAR1) signaling adaptor tyrosine kinase (2TYK2) in mice.
Packaging
5 mg in glass bottle
Biochem/physiol Actions
PF-06700841 prevents IL-23 (interleukin 23) signaling through TYK2 (Tyrosine-protein kinase 2)/JAK1 (Janus kinase 1) inhibition.
PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus.Legal InformationPfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string FC1(F)C[C@H]1C(N2[C@H]3CN(C4=CC=NC(NC5=CN(C)N=C5)=N4)C[C@@H]2CC3)=O.CC6=CC=C(S(=O)(O)=O)C=C6
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06726304 acetate PZ0346-5MG
PackagingEmpirical Formula (Hill Notation): C22H21Cl2N3O3 · C2H4O2 CAS Number: 1616287-82-1 Molecular Weight: 506.38 PubChem Substance ID: 329823854
5 mg in glass bottle
Biochem/physiol Actions
PF-06726304 is a selective inhibitor of Histone-lysine N-methyltransferase EZH2 (enhancer of Zeste homolog 2), which catalyzes trimethylation of histone H3 lysine 27 (H3K27) and is amplified and/or overexpressed in several human cancers including breast, prostate and lymphoma. PF-06726304 is a novel structural class of EZH2 inhibitor.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CC(O)=O.CC(ON=C1C)=C1C2=CC(Cl)=C(CCN(CC3=C(C)C=C(C)NC3=O)C4=O)C4=C2Cl
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06745013
Empirical Formula (Hill Notation): C21H19ClN2O3 Molecular Weight: 382.84 PubChem Substance ID: 329823810 NACRES: NA.77
PackagingКат. номер PZ0283-5MG PZ0283-25MG
25 mg in glass bottle
Biochem/physiol Actions
PF-06745013 is a potent and selective inhibitor of MAP4K4.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string NC1=C(C2=CC=C(Cl)C=C2)C=C(C3=CC=C(OC(C)(C)C(O)=O)C=C3)C=N1
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06745268
Empirical Formula (Hill Notation): C26H25F3N4O3 CAS Number: 1812190-38-7 Molecular Weight: 498.50 NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0391-5MG PZ0391-25MG
PF-06745268 is an orally available, brain penetrant, potent and selective γ-secretase modulator. PF-06745268 induces robust and sustained reduction of brain amyloid-β42 (Aβ42) in rats.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder optical activity []/D -13 to -17°, c = 1.0 in methanol Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. 2-8°C SMILES string O=C1C(N2C=C(N=C2)C)=CC=C3N1CCN(C[C@@]4(C5)[C@@]5([H])C(C)(C)OC6=C4C=C(C(F)(F)F)C=C6)C3=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06747711
Empirical Formula (Hill Notation): C26H26F3N5O2 CAS Number: 1892576-58-7 Molecular Weight: 497.51 NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0390-5MG PZ0390-25MG
PF-06747711 is a mono-imine compound. It regulates gene expression in signaling pathways by targeting a nuclear hormone receptor. It is also used to treat psoriasis.
PF-06747711 is a potent and selective RORC2 modulator.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. 2-8°C SMILES string N#CC1=CC(C(NC2=CN=C(N(C)C=C3C4CCN(C(C(C)C)=O)CC4)C3=C2C(F)(F)F)=O)=CC=C1
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06747775 PZ0302-5MG
Empirical Formula (Hill Notation): C18H22FN9O2 CAS Number: 1776112-90-3 Molecular Weight: 415.42 PubChem Substance ID: 329823824
Packaging
5 mg in glass bottle
Biochem/physiol Actions
PF-06747775 is an orally available, potent and selective inhibitor of the epidermal growth factor receptor) mutant form T790M (EGFR T790M inhibitor). PF-06747775 exhibits minimal activity against wild type EGFR.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CN1C2=NC(N3C[C@@H](NC(C=C)=O)[C@H](F)C3)=NC(NC(C(OC)=N4)=CN4C)=C2N=C1 InChI 1S/C18H22FN9O2/c1-5-13(29)21-11-8-28(6-10(11)19)18-23-15(14-16(24-18)26(2)9-20-14)22-12-7-27(3)25-17(12)30-4/h5,7,9-11H,1,6,8H2,2-4H3,(H,21,29)(H,22,23,24)/t10-,11-/m1/s1 InChI key JYIUNVOCEFIUIU-GHMZBOCLSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06748962
Empirical Formula (Hill Notation): C21H21N3O2 CAS Number: 1952261-87-8 Molecular Weight: 347.41 NACRES: NA.77
PackagingКат. номер PZ0350-5MG PZ0350-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06748962 is a potent and selective lactam-based prostaglandin EP3 receptor antagonist.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder optical activity []/D -880 to -920°, c = 0.5 in chloroform-d Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CC1=CC=CC2=NC=C(C3=CC=C([C@]4(C)C(NCCC4)=O)C(N3)=O)C=C21
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06761281
Empirical Formula (Hill Notation): C13H17NO6 CAS Number: 1854061-19-0 Molecular Weight: 283.28 MDL number: MFCD30187578 PubChem Substance ID: 329823836 NACRES: NA.77
Кат. номер PZ0318-5MG PZ0318-25MG General descriptionPF-06761281 is a small, polar dicarboxylate compound. Its structure is similar to citrate, which is the endogenous substrate of Na+-citrate cotransporter (NaCT). It is a novel, potent inhibitor of SLC13a2/3/5 (solute channel) family, along with selectivity for NaCT.ApplicationPF-06761281 has been used as a SLC13A family inhibitor, in rats to determine its unbound partition coefficient (Kpuu), to estimate its potency as a drug.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06761281 is an inhibitor of the sodium-coupled citrate transporter (NaCT or SLC13A5), which may be a target for tretment and prevention of metabolic disorders. The SLC13 transporters SLC13A2 (NaDC1), SLC13A3 (NaDC3), and SLC13A5 (NaCT) co-transport di- and tricarboxylates with multiple sodium ions into cells. PF-06761281 inhibits citrate uptake with an IC50 of 740 nM for NaCT in human hepatocytes. PF-06761281 has >25-fold in vitro selectivity for NaCT over NaDC1 and NaDC3 and was inactive in a selectivity panel of 65 targets.Other NotesThis compound was developed by Pfizer for Ion Channel research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 97% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility H2O: 20 mg/mL, clear originator Pfizer shipped in dry ice storage temp. 20°C SMILES string CC1=CC(CC[C@](CC(O)=O)(O)C(O)=O)=C(OC)N=C1 InChI 1S/C13H17NO6/c1-8-5-9(11(20-2)14-7-8)3-4-13(19,12(17)18)6-10(15)16/h5,7,19H,3-4,6H2,1-2H3,(H,15,16)(H,17,18)/t13-/m1/s1 InChI key FGYMJXFSHBLHLW-CYBMUJFWSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P301 + P330 + P331 + P310 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06764427
Empirical Formula (Hill Notation): C24H25N5O3 Molecular Weight: 431.49 MDL number: MFCD29037210 PubChem Substance ID: 329823822 NACRES: NA.77
PackagingКат. номер PZ0300-5MG PZ0300-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06764427 is a selective azaindole muscarinic receptor M1 positive allosteric modulator.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CN1C=CC(C(C=C2)=CC=C2CN3C4=CC=CN=C4C(C(N[C@@H]5[C@@H](O)COCC5)=O)=C3)=N1 InChI 1S/C24H25N5O3/c1-28-11-8-19(27-28)17-6-4-16(5-7-17)13-29-14-18(23-21(29)3-2-10-25-23)24(31)26-20-9-12-32-15-22(20)30/h2-8,10-11,14,20,22,30H,9,12-13,15H2,1H3,(H,26,31)/t20-,22-/m0/s1 InChI key FQGJDGJXEZTKDW-UNMCSNQZSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P301 + P310 + P330 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06767832
Empirical Formula (Hill Notation): C22H23N3O3S CAS Number: 1859081-58-5 Molecular Weight: 409.50 PubChem Substance ID: 329823840 NACRES: NA.77
Кат. номер PZ0323-5MG PZ0323-25MG ApplicationPF-06767832 has been studied as a M1 muscarinic acetylcholine receptor agonist.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06767832 is a cell permeable, potent and selective M1 muscarinic acetylcholine receptor Positive Allosteric Modulator (PAM). Studies have shown that PF-06767832 potentiates the activity of acetylcholine (Ach) in vitro.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 30 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CC1=CN=C(C(N[C@@H]2[C@@H](O)COCC2)=O)C=C1CC3=CC=C(C4=CSC=N4)C=C3 InChI 1S/C22H23N3O3S/c1-14-10-23-19(22(27)25-18-6-7-28-11-21(18)26)9-17(14)8-15-2-4-16(5-3-15)20-12-29-13-24-20/h2-5,9-10,12-13,18,21,26H,6-8,11H2,1H3,(H,25,27)/t18-,21-/m0/s1 InChI key VVZZHFMLRHJXTO-RXVVDRJESA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 pcodes P301 + P312 + P330 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06827443
Empirical Formula (Hill Notation): C24H24N2O4 Molecular Weight: 404.46 NACRES: NA.77
PackagingКат. номер PZ0359-5MG PZ0359-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06827443 is a otent, low clearance, orally bioavailable, and CNS penetrant muscarinic M1-selectivepositive allosteric modulator (PAM) with minimal agonist activity.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CC1=CC(CN([C@@H]2[C@@H](O)COCC2)C3=O)=C3C=C1CC4=CC=C(C5=COC=N5)C=C4
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06855800 variable hydrate
Empirical Formula (Hill Notation): C17H16ClFN4O4 · xH2O Molecular Weight: 394.78 (anhydrous basis)
Biochem/physiol ActionsКат. номер PZ0401-5MG PZ0401-25MG
PF-06855800 is a cell penetrant, potent and selective S-adenosylmethionine (SAM) competitive inhibitor of the protein arginine methyltransferase 5 (PRMT5) that exhibits anticancer activity in both in vitro and in vivo models.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. 2-8°C
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06869206
Empirical Formula (Hill Notation): C15H14ClF3N4O2 Molecular Weight: 374.75 NACRES: NA.77
Кат. номер PZ0389-5MG PZ0389-25MG ApplicationPF-06869206 has been used to selectively inhibit the activity of sodium-phosphate cotransporter 2a (NaPi2a).
Biochem/physiol Actions
PF-06869206 is a selective inhibitor against sodium-phosphate cotransporter 2A (NaPi-2a, NaPi-Iia, Na+/Pi cotransporter 2A, Na+-dependent phosphate cotransporter 2A).
PF-06869206 may be used to treat patients with mineral and hormonal derangements linked with increased cardiovascular risk in chronic kidney disease. This drug might also improve urinary phosphate excretion. PF-06869206 has an ability to decrease phosphate uptake in human embryonic kidney (HEK) cells transfected with mouse or rat renal sodium-dependent phosphate transporter genes (Npt2a).Legal InformationSold for research purposes under agreement from Pfizer Inc
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. room temp SMILES string ClC1=C(C)NC2=C1N=C(C(F)(F)F)C(C#N)=C2N3C[C@@H](CO)OCC3
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06928215
Empirical Formula (Hill Notation): C20H20N4O4 Molecular Weight: 380.40 NACRES: NA.77
Кат. номер PZ038-5MG PZ038-25MG ApplicationPF-06928215 has been used to study its inhibitory effects on cyclic GMP-AMP synthase (cGAS).
Biochem/physiol Actions
PF-06928215 is a high affinity (KD = 200 nM) active site-targeting, substrate-competitive cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 4.9 μM; in the presence of 1 mM ATP, 0.3 mM GTP, 100 nM 45-bp interferon-stimulatory dsDNA (ISD)). PF-06928215 displays no inhibitory potency against dsDNA-induced IFN-β expression in cellular cGAS assays, most likely due to limited cell-permeability and/or high levels of cellular ATP and GTP in the reporter cells employed.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. room temp
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-2545920 hydrochloride
Empirical Formula (Hill Notation): C25H20N4O · HCl CAS Number: 898562-94-2 Molecular Weight: 428.91 MDL number: MFCD30489759 NACRES: NA.77
PackagingКат. номер PZ0351-5MG PZ0351-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-2545920 hydrochloride (MP-10) is a potent and selective cyclic nucleotide phosphodiesterase (PDE) 10A competitive inhibitor with a reported IC50 value of 1.26 nM. PDE10A hydrolyzes both cAMP and cGMP, and is highly expressed in medium spiny neurons of the mammalian striatum and in basal ganglia areas where D1 and D2 dopamine receptors are expressed. PF-2545920 has been studied for treatment of schizophrenia and Huntingtons disease.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 97% (HPLC) form powder Торговая марка Pfizer® color white to brown solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CN1C=C(C2=CC=NC=C2)C(C(C=C3)=CC=C3OCC4=NC5=CC=CC=C5C=C4)=N1.[H]Cl
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-3644022 hydrate
Empirical Formula (Hill Notation): C21H18N4OS · xH2O Molecular Weight: 374.46 (anhydrous basis) MDL number: MFCD21363374 PubChem Substance ID: 329823762 NACRES: NA.77
Кат. номер PZ0188-5MG PZ0188-25MG ApplicationPF-3644022 hydrate has been used for the inhibition of mitogen-activated protein kinase 2 (MK2) in human osteosarcoma cells (U2OS) and in colorectal carcinoma cells (CT26).
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-3644022 is a potent inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MK2; Ki = 3 nM). PF-3644022 inhibits TNFa and IL-6 production in LPS-stimulated human whole blood (IC50 = 1.6 and 10.3 µM, respectively) and blocks TNF production and paw swelling in a streptococcal cell wall-induced arthritis in rats.
Features and Benefits
This compound is featured on the MAPKAPs, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.Other NotesPF3644022 has been expertly reviewed and recommended by the Chemical Probes Portal. This compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationPfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color yellow to orange solubility DMSO: 15 mg/mL originator Pfizer storage temp. 2-8°C SMILES string O.C[C@@H]1CNc2c(sc3ccc4nc(ccc4c23)-c5ccc(C)nc5)C(=O)N1 InChI 1S/C21H18N4OS.H2O/c1-11-3-4-13(10-22-11)15-6-5-14-16(25-15)7-8-17-18(14)19-20(27-17)21(26)24-12(2)9-23-19;/h3-8,10,12,23H,9H2,1-2H3,(H,24,26);1H2/t12-;/m1./s1 InChI key WHVUIWUUCVXAGR-UTONKHPSSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 - H319 pcodes P301 + P312 + P330 - P305 + P351 + P338 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-3774076
Empirical Formula (Hill Notation): C14H15ClN2O CAS Number: 1171824-96-6 Molecular Weight: 262.73 PubChem Substance ID: 329823799 NACRES: NA.77
PackagingКат. номер PZ0263-5MG PZ0263-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-3774076 is a CNS penetrant, potent, selective, partial agonist at the human α1A adrenoceptor. PF-3774076 is selective over α1B and α1D adrenoceptors.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear originator Pfizer storage temp. room temp SMILES string ClC1=CC=C2C(CC[C@H]2C3=NC=CN3)=C1COC InChI 1S/C14H15ClN2O/c1-18-8-12-10-2-3-11(14-16-6-7-17-14)9(10)4-5-13(12)15/h4-7,11H,2-3,8H2,1H3,(H,16,17)/t11-/m1/s1 InChI key CMNAOKMSNCWOHS-LLVKDONJSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P301 + P310 + P330 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-4191834
Empirical Formula (Hill Notation): C22H23N3O2S CAS Number: 1029317-21-2 Molecular Weight: 393.50 MDL number: MFCD18382581 NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0360-5MG PZ0360-25MG
PF-4191834 a selective, non-redox, non-iron chelating competitive inhibitor of 5-lipoxygenase effective in inflammation and pain.
PF-4191834 is known to reduce the indications of arthritis.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. room temp SMILES string NC(C1(CCOCC1)C2=CC=CC(SC3=CC=C(C4=CC=NN4C)C=C3)=C2)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-431396 hydrate
Empirical Formula (Hill Notation): C22H21F3N6O3S · xH2O CAS Number: 717906-29-1 Molecular Weight: 506.50 (anhydrous basis) MDL number: MFCD21608515 PubChem Substance ID: 329823759 NACRES: NA.77
Кат. номер PZ0185-5MG PZ0185-25MG ApplicationPF-431396 hydrate has been used as a dual inhibitor of proline-rich tyrosine kinase 2 (PYK2) / focal adhesion kinase (FAK) inhibitor to study its effects on phosphorylation of Yes-associated protein (YAP) at Ser127 and steady state of transcriptional coactivator with PDZ-binding motif (TAZ) . It has also been used as a PYK2/FAK inhibitor to study its effects on protein kinase A activation in human sperm samples .
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-431396 is a potent inhibitor of PYK2 and FAK kinases (IC50 = 11 and 1.5 nM, respectively). PF-431396 increases bone formation and protects against bone loss in ovariectomized rats.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is a featured product for Kinase Phosphatase Biology research. Click here, to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color off-white to blue-gray solubility DMSO: 10 mg/mL originator Pfizer storage temp. 2-8°C SMILES string O.CN(c1ccccc1CNc2nc(Nc3ccc4NC(=O)Cc4c3)ncc2C(F)(F)F)S(C)(=O)=O InChI 1S/C22H21F3N6O3S.H2O/c1-31(35(2,33)34)18-6-4-3-5-13(18)11-26-20-16(22(23,24)25)12-27-21(30-20)28-15-7-8-17-14(9-15)10-19(32)29-17;/h3-9,12H,10-11H2,1-2H3,(H,29,32)(H2,26,27,28,30);1H2 InChI key XSXCARUUZVMRGX-UHFFFAOYSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 - H319 pcodes P301 + P310 + P330 - P305 + P351 + P338 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-4708671
Empirical Formula (Hill Notation): C19H21F3N6 CAS Number: 1255517-76-0 Molecular Weight: 390.41 MDL number: MFCD18086922 PubChem Substance ID: 329823728 NACRES: NA.77
Кат. номер PZ0143-5MG PZ0143-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor. PF-4708671 inhibits S6K1 with a Ki of 20 nM and IC50 of 160 nM, while having no effect on the closely related RSK and MSK kinases.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the PKB/Akt, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color off-white solubility DMSO: 20 mg/mL originator Pfizer storage temp. room temp SMILES string CCc1cncnc1N2CCN(CC2)Cc3nc4cc(ccc4[nH]3)C(F)(F)F InChI 1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26) InChI key FBLPQCAQRNSVHB-UHFFFAOYSA-N Gene Information human ... RPS6KB1(6198)
mouse ... Rps6kb1(72508)
rat ... Rps6kb1(83840)
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-477736
Empirical Formula (Hill Notation): C22H25N7O2 CAS Number: 952021-60-2 Molecular Weight: 419.48 MDL number: MFCD16038847 PubChem Substance ID: 329823760 NACRES: NA.77
Кат. номер PZ0186-5MG PZ0186-25MG ApplicationPF-477736 has been used as a checkpoint protein 1 (CHK1) inhibitor to study the effect of CHK1 in cell cycle regulation in primary breast and lung primary epithelial cells.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-477736 may be effectively used to resensitize platinum resistant ovarian cancer cells. PF-477736 alone or in combination with other chemotherapeutic agents may be used to treat triple-negative breast cancer.
PF-00477736 is a potent, selective ATP-competitive small-molecule inhibitor that inhibits Chk1 with a Ki of 0.49 nM. The compound abrogates cell cycle arrest induced by DNA damage and enhances cytotoxicity of clinically important chemotherapeutic agents, including gemcitabine and carboplatin.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.Other NotesPF-477736 has been expertly reviewed and recommended by the Chemical Probes Portal. This compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color yellow solubility DMSO: 20 mg/mL originator Pfizer storage temp. 2-8°C SMILES string Cn1cc(cn1)-c2[nH]c3cc(NC(=O)[C@H](N)C4CCCCC4)cc5C(=O)NN=Cc2c35 InChI 1S/C22H25N7O2/c1-29-11-13(9-25-29)20-16-10-24-28-21(30)15-7-14(8-17(27-20)18(15)16)26-22(31)19(23)12-5-3-2-4-6-12/h7-12,19,27H,2-6,23H2,1H3,(H,26,31)(H,28,30)/t19-/m1/s1 InChI key NDEXUOWTGYUVGA-LJQANCHMSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-4778574
Empirical Formula (Hill Notation): C19H22N2O3S2 CAS Number: 1219633-99-4 Molecular Weight: 390.52 NACRES: NA.77
Кат. номер PZ0211-5MG PZ0211-25MG ApplicationPF-4778574 may be used as a potentiator of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) in rat cortical neurons.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-4778574 is a potent AMPA receptor positive allosteric modulator (PAM) that has been shown to enhance cognition in animal models.
Features and Benefits
This compound is featured on the Glutamate Receptors (Ion Channel Family), page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-4800567 hydrochloride
Empirical Formula (Hill Notation): C17H18ClN5O2 · HCl CAS Number: 1391052-28-0 Molecular Weight: 396.27
Кат. номер PZ0328-5MG PZ0328-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-4800567 is also known as (3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride). It can block the epidermal growth factor receptor (EGFR) at micromolar concentrations. PF-4800567 helps to improve the locomotor stimulant reaction to methamphetamine (MA) and fentanyl.
PF-4800567 is a casein kinase 1e (CK1e) selective inhibitor (IC50 = 32 nM) that is 20 fold selective for the CK1e isoform over CK1d. PF-4800567 blockes CK1e-mediated PER3 nuclear translocation, but does not effect the circadian clock in animal studies.Other NotesPF-4800567 has been expertly reviewed and recommended by the Chemical Probes Portal. This compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear (warmed) originator Pfizer shipped in dry ice storage temp. 20°C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-5006739
Empirical Formula (Hill Notation): C22H22FN7O CAS Number: 1293395-67-1 Molecular Weight: 419.45 MDL number: MFCD28386023 NACRES: NA.77
Кат. номер PZ0246-5MG PZ0246-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-5006739 is a potent inhibitor of casein kinases 1 delta (CK1) and 1 epsilon (CK1), key regulators of the suprachiasmatic nucleus (SCN) central clock and also linked to the development of drug addiction through PERIOD proteins (PER1–3) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) modulation. PF-5006739 has low nM in vitro potency for CK1/ (IC50 values of 3.9 nM for CK1 and 17.0 nM for CK1) and high kinome selectivity. PF-5006739 induced profound phase delays in circadian periodicity in both nocturnal and diurnal animal models and attenuated opioid drug-seeking behavior in a rodent operant reinstatement model.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear originator Pfizer storage temp. room temp SMILES string FC(C=C1)=CC=C1C2=C(C3=CC=NC(N)=N3)N(C4CCN(CC5=NOC=C5)CC4)C=N2
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P301 + P310 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-5274857 hydrochloride
Empirical Formula (Hill Notation): C20H25ClN4O3S · HCl CAS Number: 1373615-35-0 Molecular Weight: 473.42 MDL number: MFCD24387542 PubChem Substance ID: 329823776 NACRES: NA.77
Кат. номер PZ0217-5MG PZ0217-25MG
Biochem/physiol Actions
PF-5274857 is a hedgehog (Hh) signaling pathway inhibitor acting as a potent and selective Smoothened (Smo) antagonist with an IC50 of 5.8 nM and a Ki of 4.6 nM. PF-5274857 completely blocked downstream gene Gli1 transcriptional activity in Gli-Luc mouse embryonic fibroblast (MEF) cells with an IC50 of 2.7 nM. PF-5274857 is brain penetrant. The compound PF-5274857 showed anti-tumor activity in a mouse medulloblastoma model with an in vivo IC50 of 8.9 nM.Other NotesThis compound was developed by Pfizer for Cytokines & Growth Factors research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility H2O: 3 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string O=C(CCS(C)(=O)=O)N(CC1)CCN1C2=NC=C(Cl)C(C3=NC=C(C)C=C3C)=C2.Cl InChI 1S/C20H25ClN4O3S.ClH/c1-14-10-15(2)20(23-12-14)16-11-18(22-13-17(16)21)24-5-7-25(8-6-24)19(26)4-9-29(3,27)28;/h10-13H,4-9H2,1-3H3;1H InChI key GULNFUQAVPTTQV-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-543 hydrochloride
Empirical Formula (Hill Notation): C27H31NO4S · HCl CAS Number: 1415562-82-1 Molecular Weight: 502.07 MDL number: MFCD28411614 PubChem Substance ID: 329823785 NACRES: NA.77
Кат. номер PZ0234-5MG PZ0234-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-543 hydrochloride is a novel, cell-permeable, potent and selective inhibitor of sphingosine kinase-1 (SphK1). PF-543 inhibits SphK1 with a Ki of 3.6 nM, is sphingosine competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 decreased the level of endogenous S1P by 10-fold with proportional increase of the level of sphingosine.
PF-543 stimulates granular accumulation of microtubule-associated protein light chain 3 (LC3). It also induces LC3-I to LC3-II conversion, inhibited by autophagy inhibitors, wortmannin, 3-methyladenine (3-MA) and bafilomycin A1. In human head and neck squamous cell carcinoma (SCC) cells, PF-543 hydrochloride promotes necrosis,apoptosis and autophagy.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® storage condition desiccated color white to light brown solubility H2O: 20 mg/mL, clear originator Pfizer storage temp. 20°C SMILES string [H]Cl.CC1=CC(OCC2=CC=C(CN3[C@@H](CO)CCC3)C=C2)=CC(CS(C4=CC=CC=C4)(=O)=O)=C1 InChI 1S/C27H31NO4S.ClH/c1-21-14-24(20-33(30,31)27-7-3-2-4-8-27)16-26(15-21)32-19-23-11-9-22(10-12-23)17-28-13-5-6-25(28)18-29;/h2-4,7-12,14-16,25,29H,5-6,13,17-20H2,1H3;1H/t25-;/m1./s1 InChI key WNKWAZFYPZMDGJ-VQIWEWKSSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-562,271
Empirical Formula (Hill Notation): C21H20F3N7O3S · C6H6O3S CAS Number: 939791-38-5 Molecular Weight: 665.66 MDL number: MFCD14105612 NACRES: NA.77
Кат. номер PZ0387-5MG PZ0387-25MG ApplicationPF-562,271 has been used as a focal adhesion kinase (FAK) inhibitor to study its effects on the S100A9-induced tumor cell invasion in prostate cancer cell lines. It has also been used to study its effects on syndecan-1 (SDC-1) knockdown-induced upregulation of early growth regulator 1 (EGR1) in colon cancer cells.
Biochem/physiol Actions
PF-562,271 is a potent, ATP-competitive, reversible and selective inhibitor of FAK and Pyk2. PF-562,271 inhibits FAK phosphorylation in vivo.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder Торговая марка Pfizer® color white to brown solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. 2-8°C SMILES string CN(S(=O)(C)=O)C1=NC=CC=C1CNC2=C(C(F)(F)F)C=NC(NC3=CC4=C(C=C3)NC(C4)=O)=N2.O=S(C5=CC=CC=C5)(O)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-573228
Empirical Formula (Hill Notation): C22H20F3N5O3S CAS Number: 869288-64-2 Molecular Weight: 491.49 MDL number: MFCD11519967 PubChem Substance ID: 329823709 NACRES: NA.77
Кат. номер PZ0117-5MG PZ0117-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-573228 is a focal adhesion kinase (FAK) inhibitor; Non-receptor tyrosine kinase inhibitor.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the Fak, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound is a featured product for Kinase Phosphatase Biology research. Click here, to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 95% (HPLC) form powder Торговая марка Pfizer® color white to off-white solubility DMSO: 20 mg/mL originator Pfizer storage temp. 2-8°C SMILES string CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)c1 InChI 1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30) InChI key HESLKTSGTIBHJU-UHFFFAOYSA-N
Safety InformationRIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Узнать цену -
PF-6274484
Empirical Formula (Hill Notation): C18H14ClFN4O2 CAS Number: 1035638-91-5 Molecular Weight: 372.78 MDL number: MFCD30182370 PubChem Substance ID: 329823851
PackagingКат. номер PZ0342-5MG PZ0342-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to light brown solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OC)=C(NC(C=C)=O)C=C32 InChI 1S/C19H16ClFN4O/c1-4-11(2)24-17-8-13-16(9-18(17)26-3)22-10-23-19(13)25-12-5-6-15(21)14(20)7-12/h4-10,24H,1-2H2,3H3,(H,22,23,25) InChI key DTMQCGFVWWBONL-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-6422899
Empirical Formula (Hill Notation): C20H14ClFN4O2 CAS Number: 1621002-23-0 Molecular Weight: 396.80 MDL number: MFCD28386019 PubChem Substance ID: 329823788 NACRES: NA.77
PackagingКат. номер PZ0241-5MG PZ0241-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-6422899 is an alkynylated derivative of PF-6274484; irreversible inhibitor of EGFR kinase activity. PF-6422899 binds covalently to active-site cysteine residues in the ATP binding pocket of EGFR.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OCC#C)=C(NC(C=C)=O)C=C32 InChI 1S/C20H14ClFN4O2/c1-3-7-28-18-10-16-13(9-17(18)26-19(27)4-2)20(24-11-23-16)25-12-5-6-15(22)14(21)8-12/h1,4-6,8-11H,2,7H2,(H,26,27)(H,23,24,25) InChI key AZLXGJFHSLQCPV-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P261 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-6808472
Empirical Formula (Hill Notation): C25H27FN8O3S Molecular Weight: 538.60 NACRES: NA.77
PackagingКат. номер PZ0306-5MG PZ0306-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-6808472 is a cell permeable covalent probe suitable for click chemistry designated to measure kinase selectivity in intact cells. PF-6808472 contains sulfonyl fluoride group, which react with conserved lysine residue within kinase ATP binding site.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear (warmed) originator Pfizer storage temp. 20°C
Safety Informationpictograms GHS05 signalword Danger hcodes H314 pcodes P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 RIDADR UN 3265 8 / PGII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-956980 hydrate
Empirical Formula (Hill Notation): C18H26N6O · xH2O Molecular Weight: 342.44 (anhydrous basis) MDL number: MFCD18452852 PubChem Substance ID: 329823736 NACRES: NA.77
Кат. номер PZ0151-5MG PZ0151-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-956980 is a FGF1 receptor antagonist; PDGF receptor modulator; Flt3 tyrosine kinase modulator; and VEGF antagonist.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the PDGFR, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder optical activity []/D +33 to +40°, c = 0.5 in methanol Торговая марка Pfizer® color white to off-white solubility DMSO: 50 mg/mL originator Pfizer storage temp. 2-8°C SMILES string O.C[C@@H]1CCN(C[C@@H]1N(C)c2ncnc3[nH]ccc23)C(=O)N4CCCC4 InChI 1S/C18H26N6O.H2O/c1-13-6-10-24(18(25)23-8-3-4-9-23)11-15(13)22(2)17-14-5-7-19-16(14)20-12-21-17;/h5,7,12-13,15H,3-4,6,8-11H2,1-2H3,(H,19,20,21);1H2/t13-,15+;/m1./s1 InChI key VZUKSTKLTSSYKP-PBCQUBLHSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 + H311 + H331 pcodes P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-998425
Empirical Formula (Hill Notation): C14H14F3NO CAS Number: 1076225-27-8 Molecular Weight: 269.26 MDL number: MFCD17215970 PubChem Substance ID: 329823718 NACRES: NA.77
Кат. номер PZ0131-5MG PZ0131-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-998425 is a novel, nonsteroidal androgen receptor antagonist.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Cytokines & Growth Factors research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to off-white solubility DMSO: 10 mg/mL originator Pfizer storage temp. room temp SMILES string O[C@@H]1CCCC[C@@H]1c2ccc(C#N)c(c2)C(F)(F)F InChI 1S/C14H14F3NO/c15-14(16,17)12-7-9(5-6-10(12)8-18)11-3-1-2-4-13(11)19/h5-7,11,13,19H,1-4H2/t11-,13-/m1/s1 InChI key MENRRRXHFQYXDW-DGCLKSJQSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 - H319 pcodes P305 + P351 + P338 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-CBP1
Empirical Formula (Hill Notation): C29H36N4O3 Molecular Weight: 488.62 NACRES: NA.77
Кат. номер PZ0325-5MG PZ0325-25MG General descriptionThe gene CBP (CREB binding protein) is mapped to human chromosome 16p13.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
CBP is a transcriptional coactivator. The protein is a link between the DNA-associated transcription factors and the RNA polymerase 2 complex. It also exhibits histone acetyltransferase activity.
PF-CBP1 is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates targets of CBP in macrophages primary neurons. Also, PF-CBP1 significantly reduces levels of RGS4 mRNA levels in neurons.Other NotesThis compound was developed by Pfizer for Gene Regulation research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF06650833 PZ0327-5MG
Empirical Formula (Hill Notation): C18H20FN3O4 CAS Number: 1817626-54-2 Molecular Weight: 361.37 PubChem Substance ID: 329823841 NACRES: NA.77
Packaging
5 mg in glass bottle
Biochem/physiol Actions
PF06650833 has been studied for its use in the treatment of Waldenstrom macroglobulinemia, indicated by overproduction of IgM (immunoglobulin M)-producing lymphoplasmacytic cells.
PF06650833 is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4). IRAK4 kinase is important in innate immunity, involved in initiating signaling from Toll-like receptors and members of th einterleukin-1 receptor family. IRAK4 kinase is an attractive target for the treatment of various diseases associated with deregulated inflammation, such as rheumatoid arthritis, osteoarthritis, inflammatory bowel disease, and systemic lupus erythematosus. PF06650833 has been investigated for treatment of lupus.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string NC(C1=C(OC)C=C2C(C=CN=C2OC[C@@H]3[C@H](CC)[C@H](F)C(N3)=O)=C1)=O InChI 1S/C18H20FN3O4/c1-3-10-13(22-17(24)15(10)19)8-26-18-11-7-14(25-2)12(16(20)23)6-9(11)4-5-21-18/h4-7,10,13,15H,3,8H2,1-2H3,(H2,20,23)(H,22,24)/t10-,13+,15-/m0/s1 InChI key JKDGKIBAOAFRPJ-ZBINZKHDSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF06691283
Empirical Formula (Hill Notation): C18H18F3N3O2S Molecular Weight: 397.41 MDL number: MFCD28580117 PubChem Substance ID: 329823796
PackagingКат. номер PZ0260-5MG PZ0260-25MG
25 mg in glass bottle
Biochem/physiol Actions
PF06691283 is a new β-Secretase (BACE) inhibitor.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. 2-8°C SMILES string FC[C@@H]1[C@@]2([H])[C@@](CO[C@@H](C3=NC(C)=CO3)C2)(C4=CC=C(F)C=C4F)N=C(N)S1 InChI 1S/C18H18F3N3O2S/c1-9-7-25-16(23-9)14-5-12-15(6-19)27-17(22)24-18(12,8-26-14)11-3-2-10(20)4-13(11)21/h2-4,7,12,14-15H,5-6,8H2,1H3,(H2,22,24)/t12-,14+,15+,18+/m0/s1 InChI key LKLYLZSFUBTUBW-KDQZPGIASA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P280 - P305 + P351 + P338 - P337 + P313 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PFI-4
Empirical Formula (Hill Notation): C21H24N4O3 CAS Number: 900305-37-5 Molecular Weight: 380.44 PubChem Substance ID: 329823828 NACRES: NA.77
Кат. номер PZ0307-5MG PZ0307-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PFI-4 is an SGC chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) scaffolding protein BRPF1B. The BRPF proteins (BRPF1/2/3) assemble histone acetyltransferase (HAT) complexes of the MYST transcriptional coactivator family members MOZ and MORF. The BRPF1 protein is the scaffold subunit of the MYST acetyltransferase complex, which plays a crucial roles in DNA repair, recombination and replication as well as transcription activation. Mutations in MOZ, MORF, and BRPF1 have all been associated with cancer. BRPF1 exists in 2 different isoforms: BRPF1A and BRPF1B. PFI-4 specifically binds to BRPF1B with a Kd =13 nM as determined by ITC. It reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250nM, while showing no effect on BRPF1A. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc,
Features and Benefits
PFI-4 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC,.
This compound is a featured product for Gene Regulation research. Click here, to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.Other NotesThis compound was developed by Pfizer for Gene Regulation research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string CN(C1=CC(NC(C2=C(OC)C=CC=C2)=O)=C(N3CCCC3)C=C1N4C)C4=O InChI 1S/C21H24N4O3/c1-23-17-12-15(22-20(26)14-8-4-5-9-19(14)28-3)16(25-10-6-7-11-25)13-18(17)24(2)21(23)27/h4-5,8-9,12-13H,6-7,10-11H2,1-3H3,(H,22,26) InChI key QCIJLRJBZDBVDB-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PH-797804
Empirical Formula (Hill Notation): C22H19BrF2N2O3 CAS Number: 586379-66-0 Molecular Weight: 477.30 MDL number: MFCD18251426 PubChem Substance ID: 329823795
PackagingКат. номер PZ0259-5MG PZ0259-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PH-797804 is an orally active, potent and readily reversible ATP competitive inhibitor of the alpha isoform of human p38 MAP kinase. PH-797804 blocks inflammation-induced production of cytokines and proinflammatory mediators.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear originator Pfizer storage temp. 20-25°C SMILES string CC1=CC(OCC2=C(F)C=C(F)C=C2)=C(Br)C(N1C3=CC(C(NC)=O)=CC=C3C)=O
Safety Informationpictograms GHS07 signalword Warning hcodes H302 - H315 - H319 - H335 pcodes P280 - P301 + P312 + P330 - P304 + P340 + P312 - P305 + P351 + P338 - P337 + P313 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену
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