Pfizer® Compounds
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PF-04628935
Empirical Formula (Hill Notation): C24H26ClN7OS CAS Number: 1383719-97-8 Molecular Weight: 496.03
Кат. номер PZ0228-5MG PZ0228-25MG
Biochem/physiol Actions
PF-04628935 is a potent antagonist/inverse agonist of the ghrelin receptor, growth hormone secretagogue receptor 1a (GHS-R1a) with an IC50 of 4.6 nM. Ghrelin and GSHR are involved in regulation of food intake and long-term energy homeostasis; GSHR ligands are of interest for obesity and other metabolic disorders. PF-04628935 is orally bioavailable and brain penetrant.Other NotesThis compound was developed by Pfizer for Cytokines & Growth Factors research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear originator Pfizer storage temp. room temp
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04671536
Empirical Formula (Hill Notation): C14H18N8OS CAS Number: 1305116-69-1 Molecular Weight: 346.41 NACRES: NA.77
PackagingКат. номер PZ0314-5MG PZ0314-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04671536 is a highly potent and selective inhibitor of phosphodiesterase 8B (PDE8B) phosphodiesterase 8A (PDE8A). In primary human pancreatic islets, PF-04671536 increases insulin secretion in a glucose-dependent manner.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp
Safety Informationpictograms GHS07 signalword Warning hcodes H302 pcodes P301 + P312 + P330 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04691502
Empirical Formula (Hill Notation): C22H27N5O4 CAS Number: 1013101-36-4 Molecular Weight: 425.48 PubChem Substance ID: 329823786
Кат. номер PZ0235-5MG PZ0235-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04691502 is a potent dual mTOR/PI3K inhibitor with Ki values of 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ, α, β, γ, and mTOR, respectively, with no significant inhibitory activity at more than 80 other protein kinases, including PI 3-K downstream kinases, and MAPK family members. PF-04691502 showed antitumor activity in several non-small cell lung carcer (NSCLC) xenografts and ovarian cancer cell lines. PF-04691502 is currently in clinical trials.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color , white to yellow to light brown solubility DMSO: 2 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string CC1=C(C(N([C@H]2CC[C@H](OCCO)CC2)C3=O)=NC(N)=N1)C=C3C4=CN=C(OC)C=C4 InChI 1S/C22H27N5O4/c1-13-17-11-18(14-3-8-19(30-2)24-12-14)21(29)27(20(17)26-22(23)25-13)15-4-6-16(7-5-15)31-10-9-28/h3,8,11-12,15-16,28H,4-7,9-10H2,1-2H3,(H2,23,25,26)/t15-,16- InChI key XDLYKKIQACFMJG-WKILWMFISA-N Gene Information human ... MTOR(2475), PIK3CA(5290), PIK3CB(5291), PIK3CD(5293), PIK3CG(5294), PIK3R1(5295), PIK3R2(5296), PIK3R3(8503), PIK3R5(23533)
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04701475
Empirical Formula (Hill Notation): C17H24FN3O3S CAS Number: 1488407-52-8 Molecular Weight: 369.45 NACRES: NA.77
PackagingКат. номер PZ0215-5MG PZ0215-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04701475 is a potent and selective α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) positive allosteric potentiator.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear originator Pfizer storage temp. room temp
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04725379
Empirical Formula (Hill Notation): C19H27FN4O4S Molecular Weight: 426.51 NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0216-5MG PZ0216-25MG
PF-04725379 is a potent and selective α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) positive allosteric potentiator.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P261 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04753299
Empirical Formula (Hill Notation): C18H21NO4S CAS Number: 1289620-49-0 Molecular Weight: 347.43 MDL number: MFCD22683864 PubChem Substance ID: 329823811 NACRES: NA.77
PackagingКат. номер PZ0284-5MG PZ0284-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04753299 is a potent and selective inhibitor of LpxC (UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase) that is effective in a murine of gram-negative bacteria infection model.Other NotesThis compound was developed by Pfizer for Immunology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% form powder Торговая марка Pfizer® color white to light brown solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string O=C(NO)[C@@](S(=O)(C)=O)(C)CCC(C=C1)=CC=C1C2=CC=CC=C2 InChI 1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 InChI key GDYIQUFNICPYHF-GOSISDBHSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04802367
Empirical Formula (Hill Notation): C16H16ClN5O3 Molecular Weight: 361.78 PubChem Substance ID: 329823833
Кат. номер PZ0313-5MG PZ0313-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04802367 is also known as [N-(3-(1H-1,2,4-triazol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxamide) or PF-367. It regulates tau phosphorylation in the brain.
PF-04802367 (PF-367) is a potent and specific ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK-3/) with an IC50 value of 2.3 nM and >450-fold selectivity for GSK-3 in a panel of >400 neuroreceptors, enzymes and kinases. GSK-3 dysregulation has been implicated in the pathogenesis of neurological diseases including Alzheimers disease.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer shipped in wet ice storage temp. 20°C SMILES string ClC1=CC(C2=C(C(NCCCN3N=CN=C3)=O)N=CO2)=CC=C1OC InChI 1S/C16H16ClN5O3/c1-24-13-4-3-11(7-12(13)17)15-14(20-10-25-15)16(23)19-5-2-6-22-9-18-8-21-22/h3-4,7-10H,2,5-6H2,1H3,(H,19,23) InChI key RQFYFNAGNBUGFC-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 pcodes P301 + P312 + P330 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04827736
Empirical Formula (Hill Notation): C17H21N5O2 Molecular Weight: 327.38 NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0379-5MG PZ0379-25MG
PF-04827736 is a non-brain penetrant potent and selective inhibitor of phosphodiesterase PDE1, thought to be involved in regulation of vascular smooth muscle.Legal InformationSold for research purposes under agreement from Pfizer Inc
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CC1=NNC(C[C@H](C)NC2=NC=NC3=C2C=CC(OC)=C3OC)=C1
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04859989 hydrochloride
Empirical Formula (Hill Notation): C9H10N2O2 · HCl CAS Number: 177943-33-8 Molecular Weight: 214.65 MDL number: MFCD22419400 PubChem Substance ID: 329823792
Кат. номер PZ0250-5MG PZ0250-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid, which has been implicated in several psychiatric and neurological disorders, including schizophrenia and bipolar disorder, and thought to impair cognitive function. PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 prevented ketamine-induced disruption of performance in memory tasks in both rodents and nonhuman primates.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here, to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility H2O: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string N[C@H]1CC2=CC=CC=C2N(O)C1=O.Cl InChI 1S/C9H10N2O2.ClH/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12;/h1-4,7,13H,5,10H2;1H/t7-;/m0./s1 InChI key WZOBDOKCHIUXAY-FJXQXJEOSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04880594
Empirical Formula (Hill Notation): C19H16F2N8 CAS Number: 1111636-35-1 Molecular Weight: 394.38 NACRES: NA.77
PackagingКат. номер PZ0294-5MG PZ0294-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04880594 is a potent and selective RAF inhibitor that inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 potently inhibits tumor growth in BRAF-mutant melanoma xenograft models.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string FC(F)CN(N=C1C2=CC(C=CN3)=C3N=C2)C=C1C4=NC(NCCC#N)=NC=C4
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P280 - P304 + P340 + P312 - P305 + P351 + P338 - P337 + P313 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04885614
Empirical Formula (Hill Notation): C13H14F3N3O Molecular Weight: 285.26 NACRES: NA.77
Кат. номер PZ0210-5MG PZ0210-25MG
Biochem/physiol Actions
PF-04885614 is a potent and selective Nav1.8 inhibitor.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesThis compound was developed by Pfizer for Ion Channel research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04937319
Empirical Formula (Hill Notation): C22H20N6O4 CAS Number: 1245603-92-2 Molecular Weight: 432.43 MDL number: MFCD26960571 PubChem Substance ID: 329823838 NACRES: NA.77
Кат. номер PZ0320-5MG PZ0320-25MG General descriptionPF-04937319 is a partial activator of glycokinase (GK) enzyme.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04937319 is a glucokinase activator with an EC50 value of 174 nM. PF-04937319 was found to improve glycemic control in adults with type 2 diabetes when used in conjunction with metformin.
PF-04937319, unlike other glucokinase activators, is capable of maintaining lower-glucose levels without it resulting in hypoglycemia. In type II diabetic patients where metformin treatment is inadequate, PF-04937319 is capable of maintaining glycemic control within the acceptable risk-benefit profile.Other NotesThis compound was developed by Pfizer for Cytokines & Growth Factors research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CC(O1)=CC2=C1C=C(C(NC3=NC=C(C)N=C3)=O)C=C2OC4=CN=C(C(N(C)C)=O)N=C4 InChI 1S/C22H20N6O4/c1-12-8-24-19(11-23-12)27-21(29)14-6-17-16(5-13(2)31-17)18(7-14)32-15-9-25-20(26-10-15)22(30)28(3)4/h5-11H,1-4H3,(H,24,27,29) InChI key MASKQITXHVYVFL-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04979064
Empirical Formula (Hill Notation): C24H26N6O3 CAS Number: 1220699-06-8 Molecular Weight: 446.50 MDL number: MFCD28155091
PackagingКат. номер PZ0247-5MG PZ0247-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04979064 is an orally available, potent and selective PI3K/mTOR dual kinase inhibitor that potently inhibits tumor growth in mouse xenografts.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string CN(C(N1C2CCN(C([C@@H](O)C)=O)CC2)=O)C3=C1C4=NC(C5=CN=C(C)C=C5)=CC=C4N=C3
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P301 + P310 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04991532
Empirical Formula (Hill Notation): C18H19F3N4O3 CAS Number: 1215197-37-7 Molecular Weight: 396.36 NACRES: NA.77
PackagingКат. номер PZ0223-5MG PZ0223-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04991532 is a potent and hepatoselective glucokinase activator that reduces mean daily glucose (MDG), fasting plasma glucose (FPG) and glucose excursion in humans.Other NotesThis compound was developed by Pfizer for Cytokines & Growth Factors research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-04995274
Empirical Formula (Hill Notation): C23H32N2O6 CAS Number: 1331782-27-4 Molecular Weight: 432.51 PubChem Substance ID: 329823830 NACRES: NA.77
Кат. номер PZ0310-5MG PZ0310-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-04995274 favors the production of cyclic adenosine monophosphate (cAMP).
PF-04995274 is a potent partial agonist of serotonin 5HT4 receptor with Ki = 0.15 - 0.46 nM for 5-HT4 isoforms a, b, d and e. 5-HT4 agonists modulate cholinergic function are being studied as possible treatment for cognitive disorders associated with Alzheimer′s Disease. PF-04995274 is brain penetrant and was shown to increase brain acetylcholine levels and reversed scopolamine-induced learning deficits in the rat Morris water maze test.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string OC1(CCOCC1)CN(CC2)CCC2COC3=NOC4=C3C(O[C@@H]5CCOC5)=CC=C4 InChI 1S/C23H32N2O6/c26-23(7-12-27-13-8-23)16-25-9-4-17(5-10-25)14-29-22-21-19(30-18-6-11-28-15-18)2-1-3-20(21)31-24-22/h1-3,17-18,26H,4-16H2/t18-/m1/s1 InChI key WLLOFQROROXOMO-GOSISDBHSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-05020182
Empirical Formula (Hill Notation): C18H30N4O4 CAS Number: 1354712-92-7 Molecular Weight: 366.46 PubChem Substance ID: 329823807
PackagingКат. номер PZ0278-25MG PZ0278-5MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-05020182 is a Kv7.2/4 potassium channel opener.Other NotesThis compound was developed by Pfizer for Ion Channel research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string O=C(CC(C)(C)C)NC1=C(OC)N=C(N2CCC(OC)CC2)N=C1OC InChI 1S/C18H30N4O4/c1-18(2,3)11-13(23)19-14-15(25-5)20-17(21-16(14)26-6)22-9-7-12(24-4)8-10-22/h12H,7-11H2,1-6H3,(H,19,23) InChI key XHJMCIALHJMEBB-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-05085727
Empirical Formula (Hill Notation): C20H18F3N7 CAS Number: 1415637-72-7 Molecular Weight: 413.40 NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0355-5MG PZ0355-25MG
PF-05085727 is a potent inhibitor against cGMP-dependent phosphodiesterase PDE2 (PDE2A; IC50 = 2.3 nM) with >500-fold selectivity over other PDEs. Its 3-[(18)F]fluoroazetidinyl derivative ([(18)F]PF-05270430) has been successfully applied via i.v. injection as a brain-permeant probe for imaging brain PDE2 in live cynomolgus monkeys by positron emission tomography (PET).Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CN(N=C1)C(C2=CC=C(C(F)(F)F)C=C2)=C1C3=NN(C)C4=C3C(N5CCC5)=NC=N4
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-05089771
Empirical Formula (Hill Notation): C18H12Cl2FN5O3S2 · C7H8O3S CAS Number: 1430806-04-4 Molecular Weight: 672.56 PubChem Substance ID: 329823831
Кат. номер PZ0311-25MG PZ0311-5MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-05089771 is a selective and potent inhibitor of the human voltage-gated sodium ion channel Nav1.7 with an IC50 value of 11 nM. PF-05089771 targets the voltage-sensing domain, preferentially interacting with, and stabilizing, inactivated channel conformations by interaction with the voltage-sensor domain (VSD) of Domain 4. Nav1.7 is expressed in sensory neurons and is critical for pain processing. PF-05089771 is being investigated for the treatment of chronic neuropathic pain.Other NotesThis compound was developed by Pfizer for Ion Channel research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 30 mg/mL, clear originator Pfizer storage temp. room temp SMILES string ClC1=CC(C2=C(N)NN=C2)=C(OC3=C(Cl)C=C(S(NC4=CSC=N4)(=O)=O)C(F)=C3)C=C1.CC5=CC=C(S(=O)(O)=O)C=C5 InChI 1S/C18H12Cl2FN5O3S2.C7H8O3S/c19-9-1-2-14(10(3-9)11-6-24-25-18(11)22)29-15-5-13(21)16(4-12(15)20)31(27,28)26-17-7-30-8-23-17;1-6-2-4-7(5-3-6)11(8,9)10/h1-8,26H,(H3,22,24,25);2-5H,1H3,(H,8,9,10) InChI key NVKBPDYKPNYMDR-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-05105679
Empirical Formula (Hill Notation): C26H21FN2O3 CAS Number: 1398583-31-7 Molecular Weight: 428.45 NACRES: NA.77
Кат. номер PZ0245-5MG PZ0245-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-05105679 is an antagonist of the TRP (transient receptor potential) channel, also known as the cold and menthol receptor 1 (CMR1), with an IC50 value of 103 nM. PF-05105679 is in clinical trials for neuropathic pain. Participants taking PF-05105679 could hold their hands in a bucket of ice water for a long time before feeling pain, and pain-alleviating effects matched those of oxycodone for about one hour after administration.
PF-05105679 is an antagonist of the TRP (transient receptor potential) channel, also known as the cold and menthol receptor 1 (CMR1), with an IC50 value of 103 nM. PF-05105679 is in clinical trials for neuropathic pain. Participants taking PF-05105679 could hold their hands in a bucket of ice water for a long time before feeling pain, and pain-alleviating effects matched those of oxycodone for about one hour after administration.
Transient receptor potential cation channel subfamily M member 8 (TRPM8) antagonist, PF-05105679 [(R)-3-[(1-(4-fluorophenyl)ethyl)(quinolin-3-ylcarbonyl)amino]methylbenzoic acid] acts as a clinical tool to assess the function of TRPM8 in modulating the body temperature. It also helps to determine its role in the treatment of pain in humans.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear originator Pfizer storage temp. room temp
Safety Informationpictograms GHS07 signalword Warning hcodes H302 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-05175157
Empirical Formula (Hill Notation): C23H27N5O2 CAS Number: 1301214-47-0 Molecular Weight: 405.49 NACRES: NA.77
Кат. номер PZ0299-5MG PZ0299-25MG ApplicationPF-05175157 has been used as an acetyl-Coenzyme A carboxylase (ACC) inhibitor to study its effects on the infection of flavivirus.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-05175157 is a potent and selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 located primarily in liver and adipose tissue and isoform ACC2 dominant in skeletal and heart muscle, with IC50 values of 27 nM and 33 nM, respectively. Acetyl CoA carboxylase (ACC) generates malonyl CoA, which is a substrate for de novo lipogenesis and is also an inhibitor of mitochondrial fatty acid -oxidation through inihbition of carnitine-palmitoyl transferase I (CPT-1), responsible for the transport of long-chain fatty acyl-CoAs across the mitochondrial membrane. ACC inihibitors are hoped to inhibit de novo lipogenesis and increase -oxidation of long-chain fatty acids with potential for treatment of type 2 diabetes, hepatic steatosis, and cancer. In Phase I clinical studies for diabetes treatment, PF-05175157 inhibited de novo lipogenesis and increased net whole-body fatty acid utilization.Other NotesThis compound was developed by Pfizer for Lipid Signaling research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string CC(C)N(N=C1)C2=C1CC3(CCN(C(C4=CC(NC(C)=N5)=C5C=C4)=O)CC3)CC2=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-05180999
Empirical Formula (Hill Notation): C19H17F3N8 CAS Number: 1394033-54-5 Molecular Weight: 414.39 NACRES: NA.77
PackagingКат. номер PZ0251-5MG PZ0251-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-05180999 is an inhibitor of cyclic nucleotide phosphodiesterase-2 (PDE2).Other NotesThis compound was developed by Pfizer for Cyclic Nucleotides research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear originator Pfizer storage temp. room temp
Safety Informationpictograms GHS06 signalword Danger hcodes H301 - H315 - H319 - H335 pcodes P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-05190457
Empirical Formula (Hill Notation): C29H32N6OS CAS Number: 1334782-79-4 Molecular Weight: 512.67 MDL number: MFCD28411390 PubChem Substance ID: 329823804
PackagingКат. номер PZ0270-25MG PZ0270-5MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-05190457 is an orally available, potent and selective ghrelin receptor inverse agonist. PF-05190457 potently increases insulin secretion in glucose-stimulated human islets.Other NotesThis compound was developed by Pfizer for Cytokines & Growth Factors research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 95% (HPLC) form powder optical activity []/D +45 to +55°, c = 0.5 in methanol Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CC1=CN2C(S1)=NC(CC(N3CCC4(CN([C@H](CCC5=C6)C5=CC=C6C7=NC=NC(C)=C7)C4)CC3)=O)=C2 InChI 1S/C29H32N6OS/c1-19-11-25(31-18-30-19)22-3-5-24-21(12-22)4-6-26(24)35-16-29(17-35)7-9-33(10-8-29)27(36)13-23-15-34-14-20(2)37-28(34)32-23/h3,5,11-12,14-15,18,26H,4,6-10,13,16-17H2,1-2H3/t26-/m1/s1 InChI key ZIUDADZJCKGWKR-AREMUKBSSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-05212377 succinate
Empirical Formula (Hill Notation): C18H20N4O2S · xC4H6O4 Molecular Weight: 356.44 (free base basis)
Biochem/physiol ActionsКат. номер PZ0394-5MG PZ0394-25MG
PF-05212377 (SAM-760; WYE-103760) is an orally available, high-affinity, selective 5-hydroxytryptamine (5-HT; serotonin) receptor 5-HT6 antagonist (Ki/IC50 = 0.53/1.06 nM against 3 nM [3H]-LSD for binding human 5-HT6). PF-05212377 modulates glutamate and acetylcholine release in the cerebral cortex and hippocampus in rodents with in vivo pro-cognitive efficacy.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. room temp
Safety InformationWGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-05212384
Empirical Formula (Hill Notation): C32H41N9O4 CAS Number: 1197160-78-3 Molecular Weight: 615.73
Кат. номер PZ0281-5MG PZ0281-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-05212384, also known as PKI-587 and Gedatolisib, is a dual phosphatidylinositol-3-kinase (PI3K) / mammalian target of rapamycin (mTOR) inhibitor. PKI-587 potently inhibited class I PI3Ks (IC50 vs PI3K- = 0.4 nM), PI3K- mutants, and mTOR. PF-05212384 inhibited growth of 50 diverse human tumor cell lines at IC50s <100 nM and has been in clinical trials in patients with advanced solid tumors. PF-05212384 has also been found to sensitize cells to radiation.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 0.5 mg/mL, clear (warmed) originator Pfizer storage temp. room temp
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-05883083-00
Empirical Formula (Hill Notation): C26H30ClN5O3 Molecular Weight: 496.00 PubChem Substance ID: 329823813 NACRES: NA.77
PackagingКат. номер PZ0286-5MG PZ0286-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-05883083-00 is an analog of orally available dual Src/Abl kinase inhibitor Bosutinib.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string N#CC1=C(NC2=CC(OC)=CC=C2Cl)C3=CC(OC)=C(OCCCN4CCN(C)CC4)C=C3N=C1 InChI 1S/C26H30ClN5O3/c1-31-8-10-32(11-9-31)7-4-12-35-25-15-22-20(14-24(25)34-3)26(18(16-28)17-29-22)30-23-13-19(33-2)5-6-21(23)27/h5-6,13-15,17H,4,7-12H2,1-3H3,(H,29,30) InChI key AMBOYLXXROQMET-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06250112
Empirical Formula (Hill Notation): C22H20F2N6O2 Molecular Weight: 438.43 NACRES: NA.77
Кат. номер PZ0220-5MG PZ0220-25MG
Biochem/physiol Actions
PF-06250112 is a potent inhibitor of Bruton′s tyrosine kinase (BTK). PF-06250112 blocks both B-cell receptor and FcR-mediated signaling, and prevents FcR-dependent, Antibody-mediated proteinuria in a mouse glomerulonephritis model.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here, to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear (warmed) originator Pfizer storage temp. 20°C
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06260414
Empirical Formula (Hill Notation): C14H14N4O2S CAS Number: 1612755-71-1 Molecular Weight: 302.35 PubChem Substance ID: 329823852
PackagingКат. номер PZ0343-5MG PZ0343-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06260414 is a nonsteriodal selective androgen receptor modulator (SARM). PF-06260414 is being investigated as a treatment for muscle weakening such as that associated with muscular dystrophy and the sarcopenia associated with natural aging. PF-06260414 has anabolic activity without unwanted androgenic activity on reproductive organs, liver or kidneys.Other NotesThis compound was developed by Pfizer for Cytokines & Growth Factors research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color light orange to dark orange solubility DMSO: 5 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string C[C@H](CNS1(=O)=O)CN1C2=CC3=CC=NC(C#N)=C3C=C2 InChI 1S/C14H14N4O2S/c1-10-8-17-21(19,20)18(9-10)12-2-3-13-11(6-12)4-5-16-14(13)7-15/h2-6,10,17H,8-9H2,1H3/t10-/m1/s1 InChI key ZKAVFOXYJCREBQ-SNVBAGLBSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06260933 dihydrochloride
Empirical Formula (Hill Notation): C16H13ClN4 · 2HCl Molecular Weight: 369.68 PubChem Substance ID: 329823806 NACRES: NA.77
PackagingКат. номер PZ0272-5MG PZ0272-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06260933 dihydrochloride is a MAP4K4 inhibitor.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility H2O: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string NC1=C(C2=CC=C(Cl)C=C2)C=C(C3=CN=C(N)C=C3)C=N1.[H]Cl InChI 1S/C16H13ClN4.ClH/c17-13-4-1-10(2-5-13)14-7-12(9-21-16(14)19)11-3-6-15(18)20-8-11;/h1-9H,(H2,18,20)(H2,19,21);1H InChI key ZKIFOIROEWYGKV-UHFFFAOYSA-N
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P301 + P310 + P330 RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06263276
Empirical Formula (Hill Notation): C31H31FN8O2 CAS Number: 1421502-62-6 Molecular Weight: 566.63 NACRES: NA.77
PackagingКат. номер PZ0324-5MG PZ0324-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06263276 is an inhibitor of the Janus kinase (JAK) enzymes 1, 2, 3 and tyrosine kinase 2 (TYK2). PF-06263276 has been investigated for the treatment of psoriasis.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear originator Pfizer storage temp. room temp SMILES string FC1=C(O)C=C(CC)C(C2=CC(NN=C3C4=NC5=C(CCN(C(C6=CN=C(N7CCCCC7)C=N6)=O)C5)N4)=C3C=C2)=C1
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Узнать цену -
PF-06273340
Empirical Formula (Hill Notation): C23H22ClN7O3 CAS Number: 1402438-74-7 Molecular Weight: 479.92 PubChem Substance ID: 329823793 NACRES: NA.77
PackagingКат. номер PZ0254-5MG PZ0254-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06273340 is a brain penetrant, orally available and potent tropomyosin-related kinase (Trk) inhibitor. PF-06273340 is under development as a remedy acute and chronic pain.Other NotesThis compound was developed by Pfizer for Cytokines & Growth Factors research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color , white to yellow to brown solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CC(CO)(C)N1C2=NC(N)=NC=C2C(C(C3=CN=CC(NC(CC4=CC=C(Cl)C=N4)=O)=C3)=O)=C1 InChI 1S/C23H22ClN7O3/c1-23(2,12-32)31-11-18(17-10-28-22(25)30-21(17)31)20(34)13-5-16(9-26-7-13)29-19(33)6-15-4-3-14(24)8-27-15/h3-5,7-11,32H,6,12H2,1-2H3,(H,29,33)(H2,25,28,30) InChI key BPIWZDNVMQQBQX-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 pcodes P301 + P312 + P330 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06281355
Empirical Formula (Hill Notation): C14H15N3O4S CAS Number: 1435467-38-1 Molecular Weight: 321.35 NACRES: NA.77
PackagingКат. номер PZ0277-5MG PZ0277-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06281355 (PF-1355) is an orally available, selective and potent mechanism based inhibitor of the myeloperoxidase (MPO) that reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevated circulating cytokines. PF-06281355 suppresses albuminuria and chronic renal dysfunction in model of anti-Glomerular Basement Membrane (GBM) disease.Other NotesThis compound was developed by Pfizer for Nitric Oxide & Cell Stress research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear (warmed) originator Pfizer storage temp. room temp
Safety Informationpictograms GHS07 signalword Warning hcodes H302 pcodes P301 + P312 + P330 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06282999 PZ0375-5MG
Biochem/physiol ActionsEmpirical Formula (Hill Notation): C13H12ClN3O3S CAS Number: 1435467-37-0 Molecular Weight: 325.77 MDL number: MFCD30533689 NACRES: NA.77
PF-06282999 is an orally active thiouracil class myeloperoxidase (MPO) suicide substrate (kinact/KI = 11600 M-1s-1) that targets MPO heme group for mechanism-based irreversible inactivation wtih high selectivity over thyroid peroxidase (TPO kinact/KI <3 M-1s-1) and heme-containing cytochrome P450 (CYP) isoforms (IC50 >100 µM). PF-06282999 effectively inhibits MPO activity in human blood stimulated by LPS ex vivo (IC50 = 1.9 µM) and in blood of LPS-treated cynomolgus monkeys in vivo (5-80 mg/kg p.o. 1hr post LPS i.v.) with good pharmacokinetics and oral availability (100%/86%/75%/76% in mice/rats/dogs/monkeys). PF-06282999 also exhibits weak PXR activating activity (EC50/Emax = 279 µM/9.36-fold vs.0.8 µM/19.6-fold with rifampin).Legal InformationSold for research purposes under agreement from Pfizer Inc
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 2 mg/mL, clear originator Pfizer storage temp. room temp SMILES string O=C(N)CN(C(N1)=S)C(C2=CC(Cl)=CC=C2OC)=CC1=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06284674
Empirical Formula (Hill Notation): C17H14N4O CAS Number: 1434288-24-0 Molecular Weight: 290.32 MDL number: MFCD29037211 PubChem Substance ID: 329823823 NACRES: NA.77
PackagingКат. номер PZ0301-5MG PZ0301-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06284674 is a cell permeable, potent and selective M2 isoform of pyruvate kinase (PKM2) activator.Other NotesThis compound was developed by Pfizer for Nitric Oxide & Cell Stress research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to brown solubility DMSO: 10 mg/mL, clear originator Pfizer storage temp. room temp SMILES string O=C1N2C(C=CC=C2C)=NC(CN(C=N3)C4=C3C=CC=C4)=C1 InChI 1S/C17H14N4O/c1-12-5-4-8-16-19-13(9-17(22)21(12)16)10-20-11-18-14-6-2-3-7-15(14)20/h2-9,11H,10H2,1H3 InChI key ICTBPKWPCGSFPZ-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P280 - P304 + P340 + P312 - P305 + P351 + P338 - P337 + P313 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06291874
Empirical Formula (Hill Notation): C26H28F3N3O4 CAS Number: 1393124-08-7 Molecular Weight: 503.51 MDL number: MFCD30343861
PackagingКат. номер PZ0356-5MG PZ0356-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06291874 is an orally active, potent and selective glucagon receptor antagonist. PF-06291874 exhibits a robust glucose reductions in subjects with type 2 diabetes mellitus.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear originator Pfizer storage temp. room temp
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06297470
Empirical Formula (Hill Notation): C18H16N6O CAS Number: 1539296-45-1 Molecular Weight: 332.36 MDL number: MFCD28100803 PubChem Substance ID: 329823777
Кат. номер PZ0219-5MG PZ0219-25MG
Biochem/physiol Actions
PF-06297470 is a potent negative allosteric modulator of the Metabotropic Glutamate Receptor 5 (mGluR5). PF-06297470 binds to mGluR5 with a Ki of 0.9 nM. The compound PF-06297470 displays slight antagonism of mGluR1 (IC50 = 30.5 mM), with no agonist or antagonist activities against any other mGlu receptor subtype at concentrations up to 50 mM. PF-06297470 reduces dyskinesia in a rodent (MPTP)-rendered Parkinsonian model of L-DOPA-induced dyskinesia (PD-LID).
Features and Benefits
This compound is a featured product for Neuroscience research. Click here, to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear (warmed) originator Pfizer storage temp. 2-8°C SMILES string CN(N=C1C2=C(C)C=CN=C2)C3=C1N=CC(OCC4=NC=CC=C4)=N3 InChI 1S/C18H16N6O/c1-12-6-8-19-9-14(12)16-17-18(24(2)23-16)22-15(10-21-17)25-11-13-5-3-4-7-20-13/h3-10H,11H2,1-2H3 InChI key RDLSKDOSNKLEAQ-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06305591 dihydrate
Empirical Formula (Hill Notation): C15H22N4O · 2H2O CAS Number: 1449473-97-5 Molecular Weight: 310.39 PubChem Substance ID: 329823820 NACRES: NA.77
Кат. номер PZ0297-5MG PZ0297-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06305591 is a potent and highly selective sodium channel Nav1.8 inhibitor.
PF-06305591 is safe and has acceptable absorption, distribution, metabolism, and elimination (ADME) properties.Other NotesThis compound was developed by Pfizer for Ion Channel research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer shipped in wet ice storage temp. 20°C SMILES string C[C@@H](C(N)=O)[C@H](N)C1=NC2=CC(C(C)(C)C)=CC=C2N1 InChI 1S/C15H22N4O/c1-8(13(17)20)12(16)14-18-10-6-5-9(15(2,3)4)7-11(10)19-14/h5-8,12H,16H2,1-4H3,(H2,17,20)(H,18,19)/t8-,12+/m1/s1 InChI key APWZIFIAVVFPNT-PELKAZGASA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 pcodes P301 + P312 + P330 RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06409577
Empirical Formula (Hill Notation): C19H16ClNO3 CAS Number: 1467057-23-3 Molecular Weight: 341.79 PubChem Substance ID: 329823837 NACRES: NA.77
Кат. номер PZ0319-5MG PZ0319-25MG General descriptionPF-06409577 is a 6-chloro-indole derivative obtained from 5-bromo-6-chloro-indole.ApplicationPF-06409577 has been used to determine its potential as a therapeutic agent for diabetic nephropathy.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06409577 preserves retinal pigment epithelium cells from UV radiation by activating AMPK (AMP-activated protein kinase) signaling. This orally bioavailable and possesses pharmacokinetic properties. PF-06409577 blocks de novo lipid and cholesterol synthesis pathways that shows a decrease in hepatic lipids and mRNA expression of markers of hepatic fibrosis.
PF-06409577 is a potent and selective activator of 5′ adenosine monophosphate-activated protein kinase (AMPK).
PF-06409577 potently activates a1β1γ1 AMPK (5′ adenosine monophosphate-activated protein kinase) isoform, and prevents its dephosphorylation. It is similarly potent for β1 containing isoforms, but shows significantly lower potency for β2-containing isoforms of AMPK. Patch-clamp assays show that this compound does not inhibit hERG (human ether-a-go-go gene). It interacts with the allosteric drug and metabolite site (ADaM) of AMPK.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string ClC1=C(C2=CC=C(C3(O)CCC3)C=C2)C=C4C(NC=C4C(O)=O)=C1 InChI 1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)18(22)23)8-13(16)11-2-4-12(5-3-11)19(24)6-1-7-19/h2-5,8-10,21,24H,1,6-7H2,(H,22,23) InChI key FHQXLWCFSUSXBF-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06412154 hydrochloride
Empirical Formula (Hill Notation): C24H27N3O3 · HCl CAS Number: 1421349-19-0 Molecular Weight: 441.95 PubChem Substance ID: 329823844
PackagingКат. номер PZ0333-5MG PZ0333-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06412154 hydrochloride is a glucagon receptor antagonist.Other NotesThis compound was developed by Pfizer for Cytokines & Growth Factors research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp SMILES string [H]Cl.OC(CCNC(C1=CC=C([C@H](NC2=C(C)C=C(C=CC=C3)C3=N2)CCC)C=C1)=O)=O InChI 1S/C24H27N3O3.ClH/c1-3-6-20(26-23-16(2)15-19-7-4-5-8-21(19)27-23)17-9-11-18(12-10-17)24(30)25-14-13-22(28)29;/h4-5,7-12,15,20H,3,6,13-14H2,1-2H3,(H,25,30)(H,26,27)(H,28,29);1H/t20-;/m1./s1 InChI key BTOHFLWOXYLUQK-VEIFNGETSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06412562
Empirical Formula (Hill Notation): C19H17N5O CAS Number: 1609258-91-4 Molecular Weight: 331.37
Biochem/physiol ActionsКат. номер PZ0357-5MG PZ0357-25MG
PF-06412562 is a dopamine receptor D1 (DRD1) agonist ligand.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 30 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CC1=C(C2=C(C)N=CN=C2C)C=CC(OC3=NC=CC4=C3C=NN4)=C1
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06422913
Empirical Formula (Hill Notation): C18H13F3N6O CAS Number: 1539296-46-2 Molecular Weight: 386.33 PubChem Substance ID: 329823845
PackagingКат. номер PZ0334-5MG PZ0334-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06422913 is an orally active, potent and selective metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CN1N=C(C2=C(C(F)(F)F)C=CN=C2)C3=NC=C(OCC4=CC=CC=N4)N=C31 InChI 1S/C18H13F3N6O/c1-27-17-16(15(26-27)12-8-22-7-5-13(12)18(19,20)21)24-9-14(25-17)28-10-11-4-2-3-6-23-11/h2-9H,10H2,1H3 InChI key UHUFBNVEMLJTKS-UHFFFAOYSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06424439
Empirical Formula (Hill Notation): C22H26ClN7O · CH3SO3H CAS Number: 1469284-79-4 Molecular Weight: 536.05 PubChem Substance ID: 329823784
Кат. номер PZ0233-5MG PZ0233-25MG ApplicationPF-06424439 has been used as a diacylglycerol acyltransferase 2 (DGAT2) inhibitor:- to study its effects on cell mortality and lipid synthesis in epithelial colon cells and colorectal cancer stem cells
- to study its effects on HeLa cells
- to study its inhibitory effects on neutral lipid synthesis in HT-1080 cells
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06424439 is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).
PF-06424439 functions in reducing the hepatic lipid levels in dyslipidemic rats.Other NotesThis compound was developed by Pfizer for Lipid Signaling research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to light brown solubility H2O: 10 mg/mL, clear originator Pfizer storage temp. room temp SMILES string O=C([C@@H]1CCCN(C2=NC(NC(C3(CC3)N4N=CC(Cl)=C4)=N5)=C5C=C2)C1)N6CCCC6.CS(=O)(O)=O InChI 1S/C22H26ClN7O.CH4O3S/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28;1-5(2,3)4/h5-6,12,14-15H,1-4,7-11,13H2,(H,25,26,27);1H3,(H,2,3,4)/t15-;/m1./s1 InChI key ZSTFDNQQOJUJFL-XFULWGLBSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06439015 methanesulfonate salt
Empirical Formula (Hill Notation): C22H23FN6O3S · CH3SO3H Molecular Weight: 566.63 MDL number: MFCD27978372 PubChem Substance ID: 329823778 NACRES: NA.77
Кат. номер PZ0221-5MG PZ0221-25MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06439015 is a potent and selective inihibitor that overcomes clinical ALK (receptor tyrosine kinase anaplastic lymphoma kinase) mutations resistant to Crizotinib. PF-06439015 is potent across a broad panel of ALK mutant cell lines with an IC50 of 6.6 nM for tumor growth inhibition in a crizotinib-resistant cell line (H3122-L1196M).
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here, to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility H2O: 15 mg/mL, clear originator Pfizer storage temp. room temp SMILES string OC[C@](O)(C)C(S1)=NC(C)=C1C2=CN=C(N)C(O[C@H](C)C3=C(N4N=CC=N4)C=CC(F)=C3)=C2.CS(O)(=O)=O InChI 1S/C22H23FN6O3S.CH4O3S/c1-12-19(33-21(28-12)22(3,31)11-30)14-8-18(20(24)25-10-14)32-13(2)16-9-15(23)4-5-17(16)29-26-6-7-27-29;1-5(2,3)4/h4-10,13,30-31H,11H2,1-3H3,(H2,24,25);1H3,(H,2,3,4)/t13-,22-;/m1./s1 InChI key CVPQOLHPYNCJHK-RSUIGRPMSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P261 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06442609
Empirical Formula (Hill Notation): C24H24F4N4O3 CAS Number: 1402002-76-9 Molecular Weight: 492.47 NACRES: NA.77
PackagingКат. номер PZ0258-5MG PZ0258-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06442609 is a potent γ secretase inhibitor that produces a robust reduction of brain Aβ42 and Aβ40 in in a guinea pig model. Apparently, PF-06442609 is suitable for rodent model of AD.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 20 mg/mL, clear originator Pfizer storage temp. room temp
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P261 - P305 + P351 + P338 Target Organs Respiratory system RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06446846 hydrochloride
Empirical Formula (Hill Notation): C22H20ClN7O · xHCl CAS Number: 1632250-50-0 Molecular Weight: 433.89 (free base basis) NACRES: NA.77
Biochem/physiol ActionsКат. номер PZ0374-5MG PZ0374-25MG
PF-06446846 is a selective orally active PCSK9 inhibitor that appears to act by causing the ribosome to stall when synthesizing PCSK9. PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. PF-06446846 was found to reduce plasma PCSK9 and total cholesterol levels in rats.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder optical activity []/D -60 to -50°, c = 1 in methanol Торговая марка Pfizer® color white to beige solubility H2O: 2 mg/mL, clear originator Pfizer storage temp. room temp SMILES string O=C(C1=CC=C(N2C(N=CC=C3)=C3N=N2)C=C1)N([C@H]4CNCCC4)C5=C(Cl)C=CC=N5
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Узнать цену -
PF-06456384 trihydrochloride
Empirical Formula (Hill Notation): C35H32F3N7O3S2 · 3HCl CAS Number: 1834610-75-1 Molecular Weight: 829.18
Biochem/physiol ActionsКат. номер PZ0386-5MG PZ0386-25MG
PF-06456384 is a highly potent and selective inhibitor against voltage-gated sodium channel NaV1.7 (SCN9A; IC50 = 0.01, <0.1, 75 nM against human, mouse, rat Nav1.7, respectively, by conventional patch clamp; human Nav1.7 IC50 = 0.58 nM by PatchExpress electrophysiology) with >300-fold selectivity over other human NaVs (IC50 = 3 nM/NaV1.2, 5.8 nM/NaV1.6, 75 nM/NaV1.7, 314 nM/NaV1.1, 1.45 μM/NaV1.4, 2.59 μM/NaV1.5, 6.44 μM/NaV1.3, 26 μM/NaV1.8).Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.Параметрыassay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility H2O: 2 mg/mL, clear originator Pfizer storage temp. room temp SMILES string O=S(C(C=C1)=CC(C#N)=C1OC2=C(C3=CC(CNCCC4CCNCC4)=NC=C3)C=C(C5=CC=CC(C(F)(F)F)=C5)C=C2)(NC6=NC=NS6)=O
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06459988
Empirical Formula (Hill Notation): C19H22ClN7O3 CAS Number: 1428774-45-1 Molecular Weight: 431.88 MDL number: MFCD28987462 PubChem Substance ID: 329823819 NACRES: NA.77
Кат. номер PZ0296-ZFRT PZ0296-25MG PZ0296-5MG
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06459988 is an orally available irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant (EGFRm) forms including the secondary acquired resistance mutation T790M. PF-06459988 has minimal activity against wild-type EGFR (WT EGFR).Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear originator Pfizer storage temp. room temp SMILES string ClC1=CNC2=C1C(OC[C@@H]3[C@@H](OC)CN(C(C=C([H])[H])=O)C3)=NC(NC4=CN(C)N=C4)=N2 InChI 1S/C19H22ClN7O3/c1-4-15(28)27-7-11(14(9-27)29-3)10-30-18-16-13(20)6-21-17(16)24-19(25-18)23-12-5-22-26(2)8-12/h4-6,8,11,14H,1,7,9-10H2,2-3H3,(H2,21,23,24,25)/t11-,14+/m1/s1 InChI key ODMXWZROLKITMS-RISCZKNCSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06462894
Empirical Formula (Hill Notation): C18H23N3O3 Molecular Weight: 329.39 MDL number: MFCD28137683 PubChem Substance ID: 329823782 NACRES: NA.77
PackagingКат. номер PZ0231-5MG PZ0231-25MG
5, 25 mg in glass bottle
Biochem/physiol Actions
PF-06462894 is a muscarinic metabotropic receptor mGluR5 ligand.Other NotesThis compound was developed by Pfizer for Neuroscience research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 5 mg/mL, clear (warmed) originator Pfizer storage temp. room temp SMILES string O=C1C=C(OCC2=NC=CC=C2)N=C3COC[C@@H](CC(C)(C)C)N31 InChI 1S/C18H23N3O3/c1-18(2,3)9-14-11-23-12-15-20-16(8-17(22)21(14)15)24-10-13-6-4-5-7-19-13/h4-8,14H,9-12H2,1-3H3/t14-/m1/s1 InChI key QDIYOEYPJWXMRN-CQSZACIVSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
PF-06463922 acetate PZ0271-5MG
Empirical Formula (Hill Notation): C21H19FN6O2 · CH3COOH CAS Number: 1924207-18-0 Molecular Weight: 466.46 PubChem Substance ID: 329823805 NACRES: NA.77 ApplicationPF-06463922 acetate has been used as an inhibitor of anaplastic lymphoma kinase (ALK) to analyze the expression of adrenomedullin using qPCR.
Packaging
5 mg in glass bottle
Biochem/physiol Actions
PF-06463922 is a potent, selective brain-penetrable inhibitor of both anaplastic lymphoma kinase (ALK) and c-ros Oncogene 1 (ROS1) with strong activity against all known ALK and ROS1 mutants identified in patients with crizotinib-resistant disease. PF-06463922 is in clinical trials for the treatment of non–small cell lung cancer (NSCLC).Other NotesThis compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.Legal InformationSold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.ПараметрыQuality Level 100, assay 98% (HPLC) form powder Торговая марка Pfizer® color white to beige solubility DMSO: 10 mg/mL, clear originator Pfizer storage temp. room temp SMILES string CC(O)=O.NC1=C(O[C@@H](C2=C3C=CC(F)=C2)C)C=C(C4=C(C#N)N(C)N=C4CN(C)C3=O)C=N1 InChI 1S/C21H19FN6O2.C2H4O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12;1-2(3)4/h4-7,9,11H,10H2,1-3H3,(H2,24,25);1H3,(H,3,4)/t11-;/m1./s1 InChI key BLNAIBLTPYGILH-RFVHGSKJSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену
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