Varenicline tartrate

Empirical Formula (Hill Notation):	C13H13N3 · C4H6O6
CAS Number:	375815-87-5
Molecular Weight:	361.35
MDL number:	MFCD08460603
PubChem Substance ID:	329823673
NACRES:	NA.77

Кат. номер

PZ0004-5MG

PZ0004-25MG

Varenicline tartrate has been used to investigate its effect on sensorimotor gating in rats under prepulse inhibition (PPI). It is suitable for use as a reference standard in capillary isotachophoresis (ITP) coupled on-line with capillary zone electrophoresis (CZE) for the quantification of varenicline metabolite in urine samples. It is also suitable for use for testing its effect on locomotor and nonlocomotor behavioral deficits in rats.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Varenicline tartrate is a partial α4β2 nicotinic receptor agonist and α7 full agonist. Varenicline competitively binds to α4β2 receptors and partially stimulates without creating a full nicotine effect, while simultaneoudly blocking the ability of nicotine to bind to the receptors. Varenicline thus blocks the ability of nicotine to activate α4β2 receptors and stimulate the central nervous mesolimbic dopamine system, believed to be the neuronal mechanism underlying reinforcement and reward experienced upon smoking.
Features and Benefits
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This compound is featured on the Acetylcholine Receptors (Nicotinic), page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
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Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer®
color	white to beige
solubility	DMSO: >5 mg/mL
originator	Pfizer
storage temp.	room temp
SMILES string	O[C@H]([C@@H](O)C(O)=O)C(O)=O.C1NC[C@H]2C[C@@H]1c3cc4nccnc4cc23
InChI	1S/C13H13N3.C4H6O6/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1;5-1(3(7)8)2(6)4(9)10/h1-2,4-5,8-9,14H,3,6-7H2;1-2,5-6H,(H,7,8)(H,9,10)/t8-,9+;1-,2-/m.1/s1
InChI key	TWYFGYXQSYOKLK-CYUSMAIQSA-N

pictograms	GHS07,GHS09
signalword	Warning
hcodes	H302 - H400
pcodes	P264 - P270 - P273 - P301 + P312 - P391 - P501
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable