Tigecycline hydrate

Empirical Formula (Hill Notation):	C29H39N5O8 · xH2O
CAS Number:	1229002-07-6
Molecular Weight:	585.65 (anhydrous basis)
PubChem Substance ID:	329823688
NACRES:	NA.77

Кат. номер

PZ0021-5MG

PZ0021-25MG

Tigecycline is used to treat complicated skin and skin structure infections (cSSSI) and complicated intraabdominal infections.
TIGECYCLINE HYDRATE has been used:

• for antibiotic susceptibility testing
• to study its effects on multiple nonsmall cell lung cancer (NSCLC) cell lines
• to evaluate its effects on the binding of fluoroquinolones to human serum albumin
• as a standard to investigate the penetration of tigecycline into cornea, aqueous humor and vitreous humor

Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
air sensitive
This compound was developed by Pfizer for Immunology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
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Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
optical activity	[]/D -175 to -205°, c = 0.15 in methanol
Торговая марка	Pfizer®
color	off-white to yellow-brown
solubility	DMSO: 3 mg/mL (warmed)
originator	Pfizer
storage temp.	2-8°C
SMILES string	O.CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(cc(NC(=O)CNC(C)(C)C)c(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)N(C)C
InChI	1S/C29H39N5O8.H2O/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36;/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35);1H2/t12-,14-,21-,29-;/m0./s1
InChI key	PMPLAEFBZIFHAR-KXLOKULZSA-N

pictograms	GHS07,GHS08
signalword	Danger
hcodes	H319 - H360
pcodes	P201 - P202 - P264 - P280 - P305 + P351 + P338 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable