Pyrvinium pamoate salt hydrate

Empirical Formula (Hill Notation):	C26H28N3 · 0.5 C23H14O6 · xH2O
CAS Number:	3546-41-6
Molecular Weight:	575.70 (anhydrous basis)
PubChem Substance ID:	329819982

Кат. номер

P0027-10MG

P0027-50MG

Pyrvinium pamoate salt hydrate has been used as an activator of casein kinase 1α (CK1α) in terminal blast phase of chronic myeloid leukemia (BP-CML) and human embryonic kidney (HEK293) cells. It has also been used as an inhibitor of β-catenin in Wilms tumor
Packaging
10, 50 mg in glass bottle
Biochem/physiol Actions
Pyrvinium pamoate is a potent androgen receptor inhibitor. Androgen receptors (ARs) are nuclear hormone receptors/transcription factors that reside in the cytoplasm and activated by testosterone and dihydrotestosterone. AR inhibitors have potential therapeutic benefit in prostate cancer; competitive inhibitors and chemical castration methods have been discovered, but both therapies have undesirable side effects and/or resistance potential. A screen for non-competitive inhibitors was performed, resulting in the discovery of pyrvinium as an AR inhibitor. In comparison to competitive inhibitors, this compound does not bind to the ligand-binding domain of AR or block DNA occupancy by AR, but it inhibits AR-dependent gene expression via a distinct signaling mechanism. It is more potent than classical competitive AR antagonists and exhibits synergy with other AR inhibitors.
Features and Benefits
This compound was developed by Pfizer,. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here,.
This compound is featured on the Nuclear Receptors (Steroids), page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.

Quality Level	100,
assay	≥98% (HPLC)
form	powder
color	red
solubility	DMSO: >10 mg/mL
originator	Pfizer
storage temp.	room temp
SMILES string	O.CN(C)c1ccc2[n+](C)c(\C=C\c3cc(C)n(c3C)-c4ccccc4)ccc2c1.CN(C)c5ccc6[n+](C)c(\C=C\c7cc(C)n(c7C)-c8ccccc8)ccc6c5.Oc9c(cc%10ccccc%10c9Cc%11c(O)c(cc%12ccccc%11%12)C([O-])=O)C([O-])=O
InChI	1S/2C26H28N3.C23H16O6.H2O/c2*1-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5;24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;/h2*6-18H,1-5H3;1-10,24-25H,11H2,(H,26,27)(H,28,29);1H2/q2*+1;;/p-2
InChI key	FGNOZQNUEDSSTR-UHFFFAOYSA-L

pictograms	GHS07,GHS08
signalword	Warning
hcodes	H302 + H312 + H332 - H315 - H319 - H335 - H351
pcodes	P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
Target Organs	Respiratory system
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable