PD-166285 hydrate

Empirical Formula (Hill Notation):	C26H27Cl2N5O2·2HCl
Molecular Weight:	585.35
MDL number:	MFCD17215957
PubChem Substance ID:	329823708
NACRES:	NA.77

Кат. номер

PZ0116-5MG

PZ0116-25MG

PD-166285 Hydrate has been used as a fibroblast growth factor (FGF) signaling inhibitor to study its effects on LIM-homeodomain gene 9 (Lhx9) expression during limb development in mice.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
PD-166285 is also a potent inhibitor of Wee-1, epidermal growth factor receptor, and platelet-derived growth factor receptor β subunit (PDGFR-β). It also exhibits its inhibitory effects against mitogen-activated protein kinase (MAPK) and protein kinase C (PKC). PD-166285 shows antiproliferative and anti-migratory effects due to which it may be used as a therapeutic agent against atherosclerosis, restenosis, and cancer.
PD-166285 hydrate is a broad spectrum protein tyrosine kinase inhibitor; Src and FGFR kinase inhibitor.
Features and Benefits
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here, to learn more.
This compound is featured on the FGFR, page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.
This compound was developed by Pfizer for Kinase Phosphatase Biology research,. To learn more about Sigmas partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer,.
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Pfizer is a registered trademark of Pfizer, Inc.

Quality Level	100,
assay	98% (HPLC)
form	powder
Торговая марка	Pfizer®
color	yellow
solubility	DMSO: 20 mg/mL, H2O: 5 mg/mL
originator	Pfizer
storage temp.	room temp
SMILES string	O.Cl.Cl.CCN(CC)CCOc1ccc(Nc2ncc3C=C(C(=O)N(C)c3n2)c4c(Cl)cccc4Cl)cc1
InChI	1S/C26H27Cl2N5O2.2ClH.H2O/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28;;;/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31);2*1H;1H2
InChI key	FHIIMEXCWLFXBU-UHFFFAOYSA-N

pictograms	GHS06
signalword	Danger
hcodes	H301 - H413
pcodes	P273 - P301 + P310 + P330
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable