Empirical Formula (Hill Notation): | C22H26O7 |
CAS Number: | 32274-52-5 |
Molecular Weight: | 402.44 |
MDL number: | MFCD28168041 |
PubChem Substance ID: | 329824643 |
NACRES: | NA.25 |
Кат. номер |
SBR00002-1MG |
SBR00002-1MG-PW |
Arzanol is a polyphenol compound extracted from the plant
Helichrysum italicum which grows in the Mediterranean area.
Arzanol is a polyphenol compound extracted from the plant
Helichrysum italicum which grows in the Mediterranean area. Arzanol is known for its anti-inflammatory and antimicrobial activities. The anti-inflammatory activity was verified in an
in-vivo rat model and was found to suppress the inflammatory response of the carrageenan-induced pleurisy. Moreover it was found to have an anti-HIV-1 activity. Arzanol inhibits COX-2-derived prostaglandin synthase-1 (mPGES-1) Inhibitor
in-vitro, in human stimulated monocytes.
Arzanol inhibits the activation of inflammatory transcription factor NFB, HIV replication in T cells, releases of IL-1, IL-6, IL-8, and TNF-,and biosynthesis of PGE2 by potentially inhibiting the mPGES-1 enzyme.
Arzanol is known for its anti-inflammatory and antimicrobial activities. The anti-inflammatory activity was verified in an
in-vivo rat model and was found to suppress the inflammatory response of the carrageenan-induced pleurisy. Moreover it was found to have an anti-HIV-1 activity. Arzanol inhibits COX-2-derived prostaglandin synthase-1 (mPGES-1) Inhibitor
in-vitro, in human stimulated monocytes.
Arzanol inhibits the activation of inflammatory transcription factor nuclear factor-KB (NF-KB), human immunodeficiency virus (HIV) replication in T cells, releases of interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)- and biosynthesis of prostaglandin E2 (PGE2) by potentially inhibiting the mPGES-1 enzyme. It also possesses antioxidant and cytotoxic activity.
Soluble in dimethyl sulfoxide (DMSO) at 1 mg/mL; poorly soluble in water
biological source | Helichrysum italicum |
Quality Level | 200, |
assay | 98% |
form | powder |
storage temp. | 20°C |
SMILES string | OC1=C(CC2=C(O)C(C)=C(CC)OC2=O)C(O)=C(C(C)=O)C(O)=C1CC=C(C)C |
InChI | 1S/C22H26O7/c1-6-16-11(4)18(24)15(22(28)29-16)9-14-19(25)13(8-7-10(2)3)20(26)17(12(5)23)21(14)27/h7,24-27H,6,8-9H2,1-5H3 |
InChI key | ZOIAPLVBZQQHCG-UHFFFAOYSA-N |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point F | Not applicable |
Flash Point C | Not applicable |