Anti-Porphyromonas gingivalis antibody produced in rabbit

NACRES:

NA.41

Кат. номер

SAB4200832-25UL

SAB4200832-100UL

Porphyromonas gingivalis is a nonmotile, Gram-negative, rod-shaped, anaerobic pathogenic bacterium, belongs to the Porphyromonadaceae family, phylum Bacteroidetes class.1 P. gingivalis is involved in a number of pathogenic mechanisms including tissue colonization and destruction, as well as host defense activation. This bacterium is known for the ability to colonize at the oral cavity which consider a major public health issue. It can also be found in lung, liver, or splenic abscesses and the upper gastrointestinal tract and is related to atherosclerotic plaque disease, Cardiovascular diseases, Adverse pregnancy outcomes, Rheumatoid arthritis (RA), Meningitis or brain abscesses and Alzheimers disease. P. gingivalis ability to aggregate in biofilms is considered a significant health risk by elevated resistance to host defense mechanisms and decreased susceptibility to conventional antimicrobials agents. P. gingivalis have several potential secreted and membranal virulence factors such as Gingipains proteolytic complex (Rgp and Kgp) which degrade various host proteins, Fimbriae (FimA and Mfa1) responsible for attachment of bacterial cells to host cell surfaces and Haemagglutinins (HagA) involved in adhesion and invasion of host cells.
Anti-Porphyromonas gingivalis antibody recognizes P. gingivalis whole extract and P. gingivalis Lipopolysaccharides (LPS), the antibody has no cross reactivity with P. mirabilis or E. coli. The antibody may be used in various immunochemical techniques including Immunoblotting and ELISA. Detection of the P. gingivalis bands by Immunoblotting is specifically inhibited by the immunogen.
Physical form
Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
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Disclaimer
This product is for R&D use only, not for drug, household, or other uses.

biological source	rabbit
antibody form	IgG fraction of antiserum
description	Research area: Microbiome
form	buffered aqueous solution
species reactivity	Porphyromonas gingivalis (Lipopolysaccharides (LPS) from whole extract)
packaging	antibody small pack of 25 µL
concentration	~1 mg/mL
application(s)	immunoblotting: 1:50,000-1:100,000 using dead Porphyromonas gingivalis bacteria, indirect ELISA: 1:20,000-1:40,000 using Porphyromonas gingivalis LPS for coating.
shipped in	dry ice
storage temp.	20°C

WGK Germany	WGK 1
Flash Point F	Not applicable
Flash Point C	Not applicable