BioTracker QUMA-1 RNA G-quadruplex Live Cell Dye SCT056

RNA G-quadruplexes are formed by self-assembly of guanine-rich RNA stacks into stacked G-quartets. This can occur in protein-coding (mRNA) as well as non-coding (ncRNA) transcripts. There is growing evidence that RNA G-quadruplexes are involved in different biological functions: telomere elongation, DNA recombination, transcription, RNA post-transcriptional mechanisms (pre-mRNA processing, mRNA turnover, targeting and translation), and are associated with sevral human diseases.
BioTracker<TMSYMBOL></TMSYMBOL> QUMA-1 RNA G-quadruplex Live Cell Dye (QUMA-1) is a red-emitting fluorescent probe that can be used to study dynamics (folding and unfolding) and movements of RNA G-quadruplexes. QUMA-1 is a reversible dye that emits upon binding to G-quadruplexes and turns off upon unfolding. QUMA-1 is highly specific for RNA G-quadruplexes and does not bind to DNA, double-stranded RNA, single-stranded RNA or other RNA structures. QUMA-1 could also potentially be used to study RNA-protein interactions.
Spectral Properties
Absorbance: 555 nm
Emission: 660 nm
Research Sub Category
Live Cell Dye
Live cell fluorescent imaging
A red-emitting fluorescent probe for tracking RNA G-quadruplexes dynamics, such as folding and unfolding, in live cells.
Research Category
Cell Imaging
microRNA
RNA Metabolism & Binding Proteins
Purity: 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
Molar Mass: 628.17 g/mol
Lyophilized
Store BioTracker QUMA-1 RNA G-quadruplex -Live Cell Dye at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
Concentration: Please refer to lot specific datasheet.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

assay	≥98% (H-NMR), ≥98% (HPLC), ≥98% (LC/MS), ≥98% (elemental analysis)
application(s)	cell analysis: suitable (cell based assays)
detection method	fluorometric

WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable