5-Pregnen-3-ol-20-one
Empirical Formula (Hill Notation): | C21H32O2 |
CAS Number: | 145-13-1 |
Molecular Weight: | 316.48 |
Beilstein/REAXYS Number: | 2059026 |
EC Number: | 205-647-4 |
MDL number: | MFCD00003628 |
PubChem Substance ID: | 24899008 |
NACRES: | NA.77 |
Кат. номер |
P9129-1G |
P9129-100G |
P9129-5G |
P9129-25G |
P9129-10MG |
5-Pregnen-3-ol-20-one is suitable for use:
- as a substrate for 3-HSD at a concentration of 1 µg/mL to study the time-dependent effect of reduced oxygen tension on 3-hydroxysteroid dehydrogenase (3-HSD) activity
- as a progestin precursor to study the effects of splenic macrophages on progestin secretion of luteal cells
- in the testicular interstitial cell culture medium at a concentration of 15mg/mL
1, 5, 25, 100 g in poly bottle
One of a small number of "neurosteroids," steroids synthesized in the brain rather than peripheral sources. Decreased levels of these neurosteroids has been implicated in rodent cognitive decline with age, but studies in humans have been contradictory.
Testosterone production in rats occurs in Leydig cells of the testis via the 4 pathway. Cholesterol is first converted to pregnenolone, then to progesterone, and finally to testosterone. Pregnenolone is the key neurosteroid synthesized in steroidogenic glands. It is also present as a sulfate ester that serves as an antagonist of GABAergic neurons by interacting with -aminobutyric acid (GABA) receptor.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. P9129.pdf , Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,
biological source | synthetic (organic) |
Quality Level | 200, |
assay | 98% |
form | powder |
solubility | ethanol: soluble 10 mg/mL, clear, colorless to faintly yellow |
functional group | ketone |
shipped in | ambient |
storage temp. | room temp |
SMILES string | [H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O |
InChI | 1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 |
InChI key | ORNBQBCIOKFOEO-QGVNFLHTSA-N |
Gene Information | human ... SERPINA6(866) rat ... Ar(24208) |
Personal Protective Equipment | Eyeshields,, Gloves,, type N95 (US), |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point F | Not applicable |
Flash Point C | Not applicable |