Corticosterone

Empirical Formula (Hill Notation):	C21H30O4
CAS Number:	50-22-6
Molecular Weight:	346.46
Beilstein/REAXYS Number:	2339601
EC Number:	200-019-6
MDL number:	MFCD00037715
PubChem Substance ID:	57648276
NACRES:	NA.77

Кат. номер

27840-100MG

27840-500MG

Corticosterone (Cort) is a glucocorticoid hormone. It is also the principal hormone that mediates stress responses in birds. It is the primary adrenal cortical steroid in rat plasma. The influence of maternal Cort exposure on the developing placenta has been studied in a mouse model.
Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro. It was also used in immune suppression experiment.
Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. The role of corticosterones is vital for reproductive processes including ovulation, lutenization, development of oocytes, parturition and lactation. The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase.
Bottomless glass bottle. Contents are inside inserted fused cone.
Corticosterone is soluble in chloroform and ethanol.

Quality Level	200,
biological source	synthetic
assay	98.5% (HPLC)
form	powder or crystals
optical activity	[]20/D +223±3°, c = 1% in ethanol
mp	179-183 °C (lit.), 179-183 °C
functional group	ketone
SMILES string	C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
InChI	1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChI key	OMFXVFTZEKFJBZ-HJTSIMOOSA-N
Gene Information	human ... EBP(10682), SERPINA6(866) rat ... Ar(24208), Nr3c1(24413)

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