Human Osteoprotegerin / TNFRSF11b ELISA Kit RAB0484-1KT
The Human Osteoprotegerin ELISA (Enzyme-Linked Immunosorbent Assay) kit is an
in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Osteoprotegerin in serum, plasma, cell culture supernatants and urine.
Osteoprotegerin (OPG) is encoded by the gene mapped to human chromosome 8q24. It is a member of the TNFR (tumor necrosis factor receptor) superfamily that can act as a decoy receptor for RANKL (receptor activator of nuclear factor kappa-B ligand) and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand). OPG is expressed in a wide variety of tissues, including adult heart, lung, kidney and liver. It is secreted both as a monomeric and a dimeric protein.
Recombinant Human OPG
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure ,(sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
Binding of soluble osteoprotegerin (OPG) to sRANKL (soluble receptor activator of nuclear factor κ-B ligand) inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells. This process leads to excess accumulation of bone and cartilage. Changes in the level of serum OPG are associated with atherosclerosis and cardiovascular disorders(CVDs). It might also be associated with malignancy and plays a regulatory role in multiple myeloma, prostate, breast, bladder and gastric carcinoma. OPG plays a vital role in bone metabolism and is involved in inhibition of ovariectomy-associated bone loss in rats. It is also used as a potent biomarker for CVD.
A sample Certificate of Analysis is available for this product.
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species reactivity | human |
packaging | kit of 96 wells (12 strips x 8 wells) |
application(s) | ELISA: suitable, capture ELISA: suitable |
input | sample type serum sample type plasma sample type urine sample type cell culture supernatant(s) |
assay range | inter-assay cv: <12% intra-assay cv: <10% sensitivity: 1 pg/mL standard curve range: 1.23-900 pg/mL |
detection method | colorimetric |
shipped in | wet ice |
storage temp. | 20°C |
Gene Information | human ... TNFRSF11B(4982) |
pictograms | GHS05 |
signalword | Warning |
hcodes | H290 |
RIDADR | UN 3264 8 / PGIII |